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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Drug Resistance Mechanisms in Human Cancer Cells to Anticancer Drugs

edited by

Daekyu Sun

submission deadline 20 Sep 2025 | Viewed by 417 | Submission Open

Keywords: cancer therapy; targeted therapy; combination therapy; drug resistance; resensitization; DNA repair; DNA damage response; DNA repair inhibitors; synthetic lethality; chemoradiation

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Transplantation and Machine Perfusion

edited by

Joan Roselló-Catafau

and

Arnau Panisello-Roselló

submission deadline 20 Sep 2025 | Viewed by 416 | Submission Open

Keywords: transplantation (liver; kidney; and other organs); primary failure; ischemia-reperfusion injury; static graft preservation; HOPE; NMP; cell signaling; glycocalyx; metabolomics; mitochondria; sterile inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Biomarkers in Pancreatic Diseases

edited by

Laura Gaman

and

Mihaela Badea

submission deadline 20 Sep 2025 | Viewed by 409 | Submission Open

Keywords: pancreatic disease; pancreatic cancer; pancreatitis; biomarker; RNA

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms, Emerging Biomarkers, Novel Therapies and Personalized Treatment in Celiac Disease (CD)

edited by María Isabel Torres

submission deadline 20 Sep 2025 | Viewed by 403 | Submission Open

Keywords: celiac disease; gluten sensitivity; immune response; emerging biomarkers; novel therapies; microbiome modulation; personalized treatment

(This special issue belongs to the Section Molecular Immunology)

Antimicrobial Agents: Synthesis and Design

edited by

Silvana Alfei

submission deadline 20 Sep 2025 | Viewed by 388 | Submission Open

Keywords: multi-drug resistant Gram-negative and Gram-positive pathogens; clinically relevant superbugs; severe and almost untreatable infections; immunocompromised individuals; synthetic antimicrobial cationic macromolecules; synthetic cationic dendrimers; polymers; and copolymers; polymerizing strategies; quaternary ammonium and phosphonium salts; amino-acid modified macromolecules; electrostatic interactions and membrane permeabilization; membrane disruptors; drug delivery systems; cationic bola-amphiphiles

(This special issue belongs to the Section Molecular Microbiology)

Natural Compounds for Skeletal Muscle Health and Regeneration

edited by

Khurshid Ahmad

submission deadline 20 Sep 2025 | Viewed by 379 | Submission Open

Keywords: skeletal muscle; natural compounds; molecular mechanism; muscle regeneration; computational analysis; experimental analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Fundamental and Translational Insights into Colorectal Cancer

edited by Giuseppe Broggi

submission deadline 20 Sep 2025 | 1 articles | Viewed by 377 | Submission Open

Keywords: colorectal cancer (CRC); molecular pathways; translational research; immune checkpoint inhibitors; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Advances in Bioactive Peptides: Mechanisms of Action and Biosynthesis

edited by

Eduardo Costa

and

Sara Silva

submission deadline 20 Sep 2025 | Viewed by 375 | Submission Open

Keywords: mechanisms of action; biosynthesis; bioactive peptides (BAPs); innate immunity; synthetic peptides; therapeutic applications; antimicrobial peptides (AMPs)

(This special issue belongs to the Section Biochemistry)

Major Histocompatibility Complex Antigens in Disease

edited by Jerzy K. Kulski and Charles E. Larsen

submission deadline 20 Sep 2025 | Viewed by 370 | Submission Open

Keywords: major histocompatibility complex; immune response; human leukocyte antigen (HLA); immune function; disease susceptibility; pathogen resistance; antigenic transposable elements; cancer

(This special issue belongs to the Section Molecular Immunology)

Application of Mass Spectrometry and Chromatography in Drug Monitoring

edited by Carsten Müller

submission deadline 20 Sep 2025 | Viewed by 361 | Submission Open

Keywords: therapeutic drug monitoring; method validation; pharmacometrics; pediatric clinical pharmacology; laboratory developed tests; clinical mass spectrometry; functional tests; isobars; triple quad mass spectrometry; HR-MS; biomarker; drugs of abuse; therapeutic drugs; metabolites

(This special issue belongs to the Section Biochemistry)

Mitochondrial Energy Metabolism in Cells and Tissues

edited by

Alexander Remels

submission deadline 20 Sep 2025 | Viewed by 359 | Submission Open

Keywords: mitochondria; mitophagy; mitochondrial biogenesis; mitochondrial dynamics; fusion; fission; energy metabolism

(This special issue belongs to the Section Molecular Biology)

Fluorescence Techniques for Exploring Protein Oligomerization

edited by

Valerica Raicu

submission deadline 20 Sep 2025 | Viewed by 359 | Submission Open

Keywords: protein oligomerization; Fö rster Resonance Energy Transfer (FRET); quantifying protein interactions; single molecule fluorescence; super-resolution microscopy; fluorescence fluctuation spectroscopy

(This special issue belongs to the Section Biochemistry)

Epigenetics of Metabolic Diseases

edited by

Makrina Karaglani

submission deadline 20 Sep 2025 | Viewed by 358 | Submission Open

Keywords: epigenetics; metabolic diseases; DNA methylation; histone modifications; non-coding RNAs; obesity; diabetes; metabolic syndrome

(This special issue belongs to the Section Molecular Genetics and Genomics)

Role and Application of Stem Cells in Regenerative Medicine (Volume 5)

edited by

Oriana Trubiani

Francesca Diomede

and

Jacopo Pizzicannella

submission deadline 20 Sep 2025 | Viewed by 355 | Submission Open

Keywords: mesenchymal stem cells; tissue regeneration; regenerative medicine; immunomodulatory process

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Future of Drug Discovery and Development, 2nd Edition

edited by

William C. (Trey) Putnam

submission deadline 20 Sep 2025 | Viewed by 353 | Submission Open

Keywords: drug discovery; drug development; biotechnology; target identification; target validation; regulatory affairs; regulatory sciences; drug commercialization; pharmaceutical market access; drug screening; novel nonclinical models/approaches; advanced manufacturing; continuous manufacturing; process analytical technology; adaptive clinical trials; in silico laboratory and clinical development; rolling submissions; accelerated approvals; real-world evidence

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Diagnostic and Therapeutic Advances of Type 2 Diabetes and Obesity

edited by

Thozhukat Sathyapalan

Stephen Atkin

and

Alexandra E. Butler

submission deadline 20 Sep 2025 | Viewed by 353 | Submission Open

Keywords: type 2 diabetes; obesity; diabetes complications; cardiovascular disease; dyslipidemia; non-alcoholic fatty liver disease; metabolic syndrome; retinopathy; nephropathy; neuropathy; pharmacotherapy; insulin resistance

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Defects of Naturally Occurring Mutations

edited by Ya-Xiong Tao

submission deadline 20 Sep 2025 | Viewed by 350 | Submission Open

Keywords: protein misfolding; loss of function; gain of function; pharmacological chaperone; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Recent Progress in Extracellular Vesicles

edited by

Regina Golan-Gerstl

submission deadline 20 Sep 2025 | Viewed by 346 | Submission Open

Keywords: extracellular vesicles (EVs); macrovesicles; exosomes; cell– cell comunication

(This special issue belongs to the Section Molecular Biology)

Prostate Cancer: Molecular Biology, Prognostication and Treatment Approaches

edited by

Fabio Grizzi

and Gianluigi Taverna

submission deadline 20 Sep 2025 | Viewed by 334 | Submission Open

Keywords: prostate cancer; molecular mechanisms; diagnosis; risk-stratification; genomics; molecular biology; modelling; therapy; microenvironment; immuno-oncology; bioinformatics; imaging; spatial genomics; spatial transcriptomic; tumor complexity; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Materials for Photobiology—3rd Edition

edited by

Enrico Caruso

Antonino Mazzaglia

and

Angela Scala

submission deadline 20 Sep 2025 | Viewed by 331 | Submission Open

Keywords: light-responsive materials; phototherapeutics; photodiagnosis; bioimaging; living bioluminescent materials; light-induced therapy; UV-radiation effect; photo-antinfective materials; photosensory biology; molecular optogenetics

(This special issue belongs to the Section Materials Science)

Molecular Basis and Latest Therapeutic Strategies for Genetic Diseases in Children

edited by

Alessandro Mussa

and Chiara Leoni

submission deadline 20 Sep 2025 | Viewed by 328 | Submission Open

Keywords: rare diseases; genetic disease; gene therapy; drug development; drug repurposing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research on the Mechanism of Ferroptosis

edited by

Rita Rezzani

and

Gaia Favero

submission deadline 20 Sep 2025 | Viewed by 325 | Submission Open

Keywords: ferroptosis; programmed cell death; targeted drugs; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Research and Recent Advances of Antimicrobials

edited by

Már Másson

submission deadline 20 Sep 2025 | Viewed by 322 | Submission Open

Keywords: antibiotic; antibacterial; antifungal; antiviral; chemical synthesis; drug discovery; natural products; small molecules; peptides; proteins; oligosaccharides; polysaccharides; drug delivery; nanoparticles; solutions; gels; formulation; nanoparticles; materials; coat-ings; drug release; structure– activity; mechanism of action; clinical application; veterinary applications; agricultural applications; food preservation

(This special issue belongs to the Section Molecular Pharmacology)

Complex Interactions of Plants with Other Organisms: Particular Attention to Carnivorous and Parasitic Plants

edited by

Bartosz Płachno

submission deadline 20 Sep 2025 | Viewed by 321 | Submission Open

Keywords: carnivorous plants; parasitic plants; mycotrophic plants; hosts; phytochemistry; molecular biology; genome evolution; organ structure; cellular; genomic

(This special issue belongs to the Section Molecular Plant Sciences)

The Impact and Alterations of Hormones in Age-Related Diseases and Comorbidities

edited by

Pulak R. Manna

submission deadline 20 Sep 2025 | Viewed by 310 | Submission Open

Keywords: aging; age-related complications; comorbidities; aging and hormones; immunosenescence; impact of hormones in physiology and pathophysiology; immunocompromised conditions; neurodegenerative disorders; bodily homeostasis; healthy aging

(This special issue belongs to the Section Molecular Neurobiology)

Innovative Approaches to Enhancing Bioavailability and Bioaccessibility of Bioactive Compounds from Plant and Food Extracts

edited by

Ana-Maria Vlase

submission deadline 20 Sep 2025 | Viewed by 308 | Submission Open

Keywords: bioactive compounds; nutraceuticals; functional foods; in vitro and in vivo models; bioavailability; bioaccessibility; nanotechnology; delivery systems; molecular mechanisms; proteomics; genomics; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Environmental Contributors to Oxidative Stress: Mechanisms and Effects

edited by Halina Tkaczenko and

Natalia Kurhaluk

submission deadline 20 Sep 2025 | Viewed by 303 | Submission Open

Keywords: oxidative stress; environmental pollution; climate change; antioxidants; biological effects; toxicology; health risks; reactive oxygen species (ROS); public health; mitigation strategies; cellular damage in human and animal disorders; environmental stressors in human and animal health

(This special issue belongs to the Section Molecular Biology)

New Insights into Molecular Mechanisms of Chronic Kidney Disease

edited by

Lǎcrǎmioara Ionela Butnariu

submission deadline 20 Sep 2025 | Viewed by 296 | Submission Open

Keywords: chronic kidney disease; molecular mechanism; signaling pathways; endothelial dysfunction; inflammation; genetic variants; epigenetics; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Genomics Advances in Behaviours

edited by

Péter Pikó

submission deadline 20 Sep 2025 | Viewed by 296 | Submission Open

Keywords: unhealthy and healthy behaviors; smoking; sleeping; eating; alcoholism; gambling; aggression; addictive behaviors; physical activity; mental disorders

(This special issue belongs to the Section Molecular Biology)

Thyroid Cancer: From Pathophysiology to Novel Therapies

edited by Miklós Bodor

submission deadline 20 Sep 2025 | Viewed by 293 | Submission Open

Keywords: thyroid cancer; therapies; cell signaling; biomarker; kinase inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbial Mediators: The Bridge Between Soils, Plants, and Animal Infectious Diseases

edited by Wensheng Fang,

Tilocca Bruno

and Bin Huang

submission deadline 20 Sep 2025 | Viewed by 285 | Submission Open

Keywords: micro-organisms; soil health; plant– microbe interactions; microbial regulation; agricultural ecosystems; animal infectious diseases; microbiome; microbiota

(This special issue belongs to the Section Molecular Microbiology)

Molecular Biology of Chagas Disease, Leishmaniasis, and West Nile Virus Vectors in the Old and New World

edited by

Ildefonso Fernández-Salas

submission deadline 20 Sep 2025 | Viewed by 281 | Submission Open

Keywords: triatominae; Trypanosoma cruzi; Leishmania; Culex; Lutzomya; phlebotomus; epidemiology; neglected; populations; vectors

(This special issue belongs to the Section Molecular Microbiology)

Thyroid Function in Human Diseases: From Physiopathology to Clinical Impact on Human Health

edited by

Rosa Maria Paragliola

and Andrea Corsello

submission deadline 20 Sep 2025 | Viewed by 278 | Submission Open

Keywords: thyroid physiology; hypothyroidism; hyperthyroidism; central hypothyroidism; inappropriate TSH secretion syndrome; drugs interfering with thyroid function; sick euthyroid syndrome; consumptive hypothyroidism syndrome

(This special issue belongs to the Section Molecular Biology)

Shaping Macrophages Polarization as an Emerging Therapeutic Approach

edited by

Cristina Maccallini

submission deadline 20 Sep 2025 | Viewed by 278 | Submission Open

Keywords: macrophage polarization; M1 macrophages; M2 macrophages; immune modulation; small molecules; therapeutic strategies; inflammation; cancer immunotherapy; drug resistance

(This special issue belongs to the Section Molecular Immunology)

Molecular Effects of Exercise Training in the Prevention and Treatment of Cardiovascular Diseases

edited by

Maxime Pellegrin

submission deadline 20 Sep 2025 | Viewed by 274 | Submission Open

Keywords: atherosclerosis; cardiovascular disease; exercise training; molecular mechanisms; training modalities

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Molecular Research in Polymers and Organic Semiconductors

edited by Ovidio Amado Almanza

submission deadline 20 Sep 2025 | Viewed by 269 | Submission Open

Keywords: polymer; organic semiconductors; molecular design; molecular interactions; thermal properties; optical properties; biointerfaces; sustainable materials

(This special issue belongs to the Section Materials Science)

Attosecond Science: Toward Applications in Biology, Chemistry and Medicine

edited by

Predrag Ranitovic

submission deadline 20 Sep 2025 | Viewed by 269 | Submission Open

Keywords: ultrafast light– matter interaction; high-harmonic generation; strong-field ionization; free-electron laser (FEL) ultrafast sources

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Transglutaminase 2 and Cellular Functions: 2nd Edition

edited by

Carlo Mischiati

and

Simone Beninati

submission deadline 20 Sep 2025 | Viewed by 268 | Submission Open

Keywords: transglutaminase type 2; transglutaminase family; celiac disease; neurodegenerative diseases; multiple sclerosis; central nervous system injuries; TG2

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Aspects of Environmental Pollutants on Soil Microbial

edited by Elżbieta Wołejko, Urszula Wydro and Agata Jabłońska-Trypuć

submission deadline 20 Sep 2025 | Viewed by 266 | Submission Open

Keywords: biomonitoring; soil contamination; molecular biology techniques; microbiological activity in soil; toxicological tests; bioindication; ecotoxicology; omics

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms and Drug Treatment in Alzheimer’s Disease

edited by

Roberto Dominici

and Diego Dolcetta

submission deadline 20 Sep 2025 | Viewed by 265 | Submission Open

Keywords: Alzheimer’ s disease (AD); glia; immune system; neurotoxicity; inflammation; beta-Amyloid (bA); neurofibrillary tangles (NFTs)

(This special issue belongs to the Section Molecular Neurobiology)

Discovery of Proteins Leading to New Asthma Treatments

edited by

Alberto Spisni

and

Elena Ferrari

submission deadline 20 Sep 2025 | Viewed by 265 | Submission Open

Keywords: asthma; allergens; proteomic analysis; bioinformatics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Therapeutical Advances in Multiple Sclerosis

edited by Arturo Mangas and

Rafael Coveñas Rodríguez

submission deadline 20 Sep 2025 | Viewed by 259 | Submission Open

Keywords: multiple sclerosis; neurodegenerative disease; chronic disease; autoimmune disease; biological markers; new drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Natural Products in Inflammation

edited by

Antonia Cianciulli

submission deadline 20 Sep 2025 | Viewed by 258 | Submission Open

Keywords: inflammation; natural products; immunomodulation; bioactive compounds; drug discovery; drug target identification; anti-inflammatory activity; antioxidant activity; cellular signalling pathways

(This special issue belongs to the Section Molecular Pharmacology)

Advanced Molecular Research in Thromboinflammation

edited by Emanuele Valeriani

submission deadline 20 Sep 2025 | Viewed by 257 | Submission Open

Keywords: blood coagulation factors; blood platelets; endothelium; inflammation; thromboinflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immune Regulation in Lung Diseases

edited by

Chiara Colarusso

and

Rosalinda Sorrentino

submission deadline 20 Sep 2025 | Viewed by 248 | Submission Open

Keywords: lung disease; immune system; lung immune cells; lung epithelial cells; therapy

(This special issue belongs to the Section Molecular Immunology)

Pathogenesis and Treatment of Prostate Cancer

edited by

Vincenzo Fiorentino

submission deadline 20 Sep 2025 | Viewed by 244 | Submission Open

Keywords: prostate cancer; pathogenesis; genetic mutations; target therapy; surgery; radiation therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds from Foods Against Diseases

edited by Jongbin Lim

submission deadline 20 Sep 2025 | Viewed by 243 | Submission Open

Keywords: diet-related diseases; bioactive compounds; analytical techniques; functional foods; molecular interaction; health benefits

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Perspectives in Nanoadsorption

edited by Carmen María Del Hoyo Martinez

submission deadline 20 Sep 2025 | Viewed by 241 | Submission Open

Keywords: nanoadsorption; nanomaterials; molecular mechanism; emerging contaminants removal in pharmaceutical and food industries; X-ray diffraction (XRD); thermal analysis techniques (DSC); Fourier-transform infrared spectroscopy (FTIR); Raman spectroscopy; molecular functionalization in nanoadsorption

(This special issue belongs to the Section Materials Science)

A New Era for Structures and Functions of Amyloid Fibrils in Neurodegenerative Diseases

edited by Masahiro Enomoto

submission deadline 20 Sep 2025 | Viewed by 236 | Submission Open

Keywords: neurodegenerative disease; structural mechanisms; super-resolution microscopy; cryo-electron microscopy (cryo-EM); cryo-electron tomography (cryo-ET)

(This special issue belongs to the Section Molecular Neurobiology)

Brain Cancers: Molecular Diagnostic and Therapeutic Approaches

edited by

Carmine Antonio Donofrio

submission deadline 20 Sep 2025 | Viewed by 234 | Submission Open

Keywords: brain tumors; gliomas; meningiomas; pituitary tumors; molecular diagnosis; liquid biopsy; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1301-1350 on page 27 of 69.

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