Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.1
4.9
Journals
IJMS
Special Issues
Molecular Diagnosis and Targeted Therapies in Ischemic Stroke
ijms-logo
Submit to Special Issue Submit Abstract to Special Issue Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Molecular Diagnosis and Targeted Therapies in Ischemic Stroke

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 670

Special Issue Editors

Dr. Alicia Aliena-Valero

E-Mail Website
Guest Editor
Instituto de Investigación Sanitaria La Fe, Valencia, Spain
Interests: ischemic stroke; cellular senescence; ageing; cerebroprotection
Dr. María Castelló-Ruiz

E-Mail Website
Guest Editor
Department of Cell Biology, Functional Biology and Physical Anthropology, Faculty of Biology, Universitat de València, Burjassot, 46100 Valencia, Spain
Interests: Ischaemic stroke; cellular senescence; cerebroprotection; oestrogens; ageing; inflammation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of ischemic stroke management has witnessed significant advances in recent years, with improved diagnostic tools and therapeutic options. However, the heterogeneity of ischemic stroke and the complex interplay of various factors continue to pose challenges in achieving optimal outcomes, and this remains a major global health challenge.

This Special Issue explores the multifaceted nature of ischemic stroke pathophysiology by integrating basic science research, translational studies, and clinical evidence. We aim to deepen our comprehension of the complex molecular mechanisms underlying ischemic stroke pathogenesis, such as oxidative stress, inflammation, and excitotoxicity. By identifying novel therapeutic targets, we can develop innovative treatments that address these mechanisms and potentially mitigate the damage caused by stroke. Furthermore, we seek to translate research findings into improved clinical practises for patients with ischemic stroke. These therapies may encompass neuroprotective agents, anti-inflammatory drugs, and strategies to enhance brain plasticity.

We invite submissions from researchers and professionals to share their latest findings and insights on this important topic.

Dr. Alicia Aliena-Valero
Dr. María Castelló-Ruiz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ischemic stroke
  • cerebral protection
  • repair treatments
  • therapeutic approaches

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

16 pages, 3820 KiB  
Article
Complexity of Damage-Associated Molecular Pattern Molecule Expression Profile in Porcine Brain Affected by Ischemic Stroke
by Dominika Golubczyk, Aleksandra Mowinska, Piotr Holak, Piotr Walczak, Miroslaw Janowski and Izabela Malysz-Cymborska
Int. J. Mol. Sci. 2025, 26(8), 3702; https://doi.org/10.3390/ijms26083702 - 14 Apr 2025
Viewed by 223
Abstract
Studies using large animal models are essential for better understanding the molecular processes underlying neurological diseases, including ischemic stroke, and serve as a robust foundation for evaluating potential therapies. To better understand the complex role of damage-associated molecular pattern molecules (DAMPs) after ischemia, [...] Read more.
Studies using large animal models are essential for better understanding the molecular processes underlying neurological diseases, including ischemic stroke, and serve as a robust foundation for evaluating potential therapies. To better understand the complex role of damage-associated molecular pattern molecules (DAMPs) after ischemia, we aimed to determine their expression in the porcine brain affected by ischemic stroke at four time points: 6 h, 24 h, 3 days and 7 days post-stroke. Within the first 24 h after the stroke, we observed the increased expression of several key factors, including calcium-binding proteins, peroxiredoxins, heat shock proteins and interleukins (1α and 1β, IL10, IL17α). Moreover, by day 7, multiple DAMPs were up-regulated, coinciding with an enhanced expression of vascular endothelial growth factor A (VEGFA) in the affected hemisphere. The effects of ischemic stroke were also evident systemically, as indicated by the altered serum levels of both pro- and anti-inflammatory interleukins, reflecting dynamic inflammatory response. To conclude, our findings provide new insights about the time-dependent DAMP activity in a large animal model of ischemic stroke, highlighting the simultaneous occurrence of an ongoing inflammatory response and the possible initiation of vascular remodeling as early as one week after stroke onset. Full article
(This article belongs to the Special Issue Molecular Diagnosis and Targeted Therapies in Ischemic Stroke)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop