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Nanostructures: From Synthesis, Modification to Biomedical Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 568

Special Issue Editors


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Guest Editor
Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: nanoparticles; bio-applications; nanomedicine; nano-antimicrobials; inorganic synthesis; wet chemistry; autoclave

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Guest Editor
Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: wet chemical synthesis and characterization of a variety of inorganic nanoscale materials for biomedical applications
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Special Issue Information

Dear Colleagues,

The synthesis of primary nanoparticles is now a preliminary step in the preparation of advanced multi-functional nanostructures. New developments in the design of nanostructures, emphasizing properties such as size, shape, surface functionalization, and structural composition (known as 4S’s), reflect innovations regarding the optimization of functionality and targeting capabilities, which are vital for the integration of nanomaterials into personalized medicine. This Special Issue aims to provide an interdisciplinary platform for researchers to exchange insights and advances in the multifaceted field of nanotechnology, with direct implications for healthcare and therapeutic innovations. Inorganic nanoparticles with intrinsic functionalities, hybrid organic–inorganic nanostructures and/or quantum dots, and unique optical, electronic and magnetic properties have emerged as powerful tools in photocatalysis, medical imaging and biosensing. This has enabled the early detection and monitoring of disease, as well as the efficient transport of drugs to specific cells/tissues. The scope of this Special Issue includes biomedical applications and the use of therapeutic solutions against multi-drug-resistant bacterial strains, as well as the diagnosis and therapy of amyloidopathies, including neurodegenerative diseases. This Special Issue will also address the post-synthetic modification/fabrication methods applied to nanomaterials in order to enhance their performance, stability, and biocompatibility in complex biological environments. We also welcome papers that address surface engineering, functional coatings, and targeting strategies.

Dr. Kleoniki Giannousi
Prof. Dr. Catherine Dendrinou-Samara
Guest Editors

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Keywords

  • nanostructures
  • post-synthetic methods
  • multi-drug resistant bacteria
  • amyloidopathies
  • neurodegeneration
  • photocatalysis
  • biosensors

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Published Papers (1 paper)

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Research

30 pages, 2853 KiB  
Article
Biosynthesis of Gold Nanostructures and Their Virucidal Activity Against Influenza A Virus
by Fernanda Contreras, Katherine Rivero, Jaime Andrés Rivas-Pardo, Fabiana Liendo, Rodrigo Segura, Nicole Neira, Mauricio Arenas-Salinas, Marcelo Cortez-San Martín and Felipe Arenas
Int. J. Mol. Sci. 2025, 26(5), 1934; https://doi.org/10.3390/ijms26051934 - 24 Feb 2025
Viewed by 359
Abstract
Bacteria in natural environments often encounter high concentrations of metal ions, leading to the development of defense mechanisms such as chemical reduction. This process can result in the formation of nanostructures (NS) ranging from 1–100 nm, which have valuable properties for various applications, [...] Read more.
Bacteria in natural environments often encounter high concentrations of metal ions, leading to the development of defense mechanisms such as chemical reduction. This process can result in the formation of nanostructures (NS) ranging from 1–100 nm, which have valuable properties for various applications, including as virucidal agents. Currently, metallic NS with virucidal activity are used in disinfectants and surface protection products. However, their production mainly relies on physical and chemical methods, which are often complex, toxic, and energy-intensive. A sustainable alternative is the biosynthesis of nanostructures. Our research focuses on the biosynthesis of gold nanostructures (AuNS) using environmental bacteria and their proteins, with the aim of exploring their potential as agents to destroy the influenza A virus. We screened bacteria under conditions with HAuCl4, identifying eight microorganisms capable of growing in high gold concentrations. Staphylococcus haemolyticus BNF01 showed the highest resistance and Au(III) reduction, growing up to 0.25 mM in HAuCl4. Bioinformatic analysis revealed five proteins with potential Au(III)-reductase activity, which were cloned and expressed in Escherichia coli. These proteins reduced gold to form AuNPs, which were purified, characterized for size, shape, and surface charge, and tested against influenza A, showing significant virucidal effects, likely due to interactions with viral proteins. Full article
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