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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Natural Products for Neuroprotection and Neurodegeneration

edited by

Patrycja Kupnicka

submission deadline 20 Apr 2026 | 4 articles | Viewed by 5422 | Submission Open

Keywords: natural products; bioactive compounds; neuroprotection; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Micro-Nano Materials for Drug Delivery and Disease Treatment

edited by

Maoquan Chu

submission deadline 20 Apr 2026 | 3 articles | Viewed by 5387 | Submission Open

Keywords: biomaterials; nanoparticle-loaded bacterial cells; nanoparticle-loaded cells; bioimaging and diagnosis; therapy

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Plant Genomics and Genetics: 3rd Edition

edited by

Hengling Wei

submission deadline 20 Apr 2026 | 6 articles | Viewed by 5249 | Submission Open

Keywords: plant genomics; plant genetics; abiotic stresses; salt resistance; genome; next-generation sequencing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Type 1 Diabetes: Molecular Mechanisms and Therapeutic Approach

edited by Preeti Chhabra

submission deadline 20 Apr 2026 | 2 articles | Viewed by 5230 | Submission Open

Keywords: type 1 diabetes; microbiome; proteomics; immunotherapy; β -cell replacement; single-cell sequencing; stem cells; gene editing technologies; tolerance

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Microbiology in the Omics Era: Genomics, Metagenomics and Computational Insights

edited by

Fei Liu

submission deadline 20 Apr 2026 | 2 articles | Viewed by 5220 | Submission Open

Keywords: microbial genomics; metagenomics; computational biology; antimicrobial resistance; host– microbe interactions; multi-omics integration; bioinformatics tools; machine learning in microbiology

(This special issue belongs to the Section Molecular Microbiology)

Germline Stem Cells: New Insights

edited by

Thomas Skutella

submission deadline 20 Apr 2026 | 1 articles | Viewed by 5215 | Submission Open

Keywords: signaling pathway; spermatogonia development; oocyte development; microarray analysis; single-cell sequencing; epigenetic mechanisms; germline stem cell

(This special issue belongs to the Section Molecular Biology)

Tea and Health

edited by

Mingzhe Yao

and

Kang Wei

submission deadline 20 Apr 2026 | 3 articles | Viewed by 5179 | Submission Open

Keywords: tea plant (Camellia sinensis); molecular mechanism; human health; nutrients; quality-related component; genes identification

(This special issue belongs to the Section Molecular Plant Sciences)

The Blood–Brain Barrier and Neuroprotection

edited by Aruna Sharma and Hari Shanker Sharma

submission deadline 20 Apr 2026 | 4 articles | Viewed by 5178 | Submission Open

Keywords: blood– brain barrier; neurodegenerative diseases; nanoformulations; drug development; delivery systems

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Genetics, Breeding, and Multi-Omics Approaches in Rice Research

edited by

Zakaria Prodhan

submission deadline 20 Apr 2026 | 5 articles | Viewed by 5062 | Submission Open

Keywords: rice genetics and breeding; molecular breeding of rice; rice genomics and proteomics; genes related to abiotic stress tolerance in rice; molecular biology and multi-omics in rice research

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Targets and Immunotherapy for Autoimmune Diseases

edited by

Neetu Srivastava

submission deadline 20 Apr 2026 | 1 articles | Viewed by 4948 | Submission Open

Keywords: autoimmunity; autoimmune diseases; immunotherapy; signaling pathway; molecular targets; antibody; T cells; B cells

(This special issue belongs to the Section Molecular Immunology)

Molecular Perspectives in Nanomedicine

edited by

Stefano Leporatti

submission deadline 20 Apr 2026 | 1 articles | Viewed by 4866 | Submission Open

Keywords: nanomedicine; drug delivery; nano therapy and diagnostics; micro and nanofluidic tools; hybrid nanoparticles; CAR-T nanotechnologies

(This special issue belongs to the Section Molecular Nanoscience)

Techniques and Strategies in Drug Design and Discovery, 3rd Edition

edited by

George Mihai Nitulescu

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4860 | Submission Open

Keywords: drug discovery; drug development; target identification; computational drug design; structure-based drug design; ligand-based drug design

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in Polymeric Biomaterials

edited by

Diego Acevedo

submission deadline 20 Apr 2026 | 1 articles | Viewed by 4833 | Submission Open

Keywords: biopolymers; biocomposites; nanomaterials; applications

(This special issue belongs to the Section Materials Science)

Isolation and Biological Activities of Natural Products: Focus on Molecular Advance

edited by Pedro Ferreira and

Patricia Reboredo-Rodríguez

submission deadline 20 Apr 2026 | 4 articles | Viewed by 4796 | Submission Open

Keywords: natural products; sustainable isolation; biological activities; therapeutic potential; structure-activity relationships; omics technologies; bioavailability; functional foods; green chemistry; molecular docking

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease

edited by Rifaat Safadi and Johnny Amer

submission deadline 20 Apr 2026 | 5 articles | Viewed by 4725 | Submission Open

Keywords: MASLD (metabolic dysfunction-associated steatotic liver disease); lipotoxicity; inflammation; mitochondrial dysfunction; gut– liver axis; liver– spleen axis; fibrosis biomarkers; translational hepatology; precision liver medicine; insulin resistance; molecular therapeutics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Characterization and Biological Function of Plant Extracts

edited by

Simonetta Cristina Di Simone

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4724 | Submission Open

Keywords: plant extracts; phytochemical characterization; bioactive compounds; biological activity; molecular mechanisms; gene expression; pharmacognosy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights and Treatments for Gynecological Cancers

edited by

Nicoletta D'Alessandris

submission deadline 20 Apr 2026 | 1 articles | Viewed by 4610 | Submission Open

Keywords: gynecological cancers; cancers; endometrial cancers; cervical cancer; tumor microenvironment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

False-Positive and False-Negative Laboratory Biomarkers

edited by Michela Salvatici and Lorenzo Drago

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4607 | Submission Open

Keywords: biomarkers; false positives/negatives; protein biomarkers; nucleic acid markers; multi-omics; single-cell sequencing; liquid biopsy

(This special issue belongs to the Section Biochemistry)

Molecular and Cellular Research on the Glioma and Tumor Microenvironment

edited by

Maria Beatrice Morelli

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4544 | Submission Open

Keywords: tumour microenvironment; immune cells; cell siganling; tumor niche; tumor heterogeneity; TMZ resistance; new therapeutic strategies; endothelial cells; fibroblasts; extracellular matrix

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Quadruplex DNA and Its Ligands for Disease Treatment

edited by

Ding Li

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4543 | Submission Open

Keywords: quadruplex; i-motif; transcriptional regulation; apoptosis; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Inflammatory Bowel Disease: Focus on Molecular Research

edited by David Meriwether and

Hon Wai Koon

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4542 | Submission Open

Keywords: inflammatory bowel disease; gut microbiota; genomic sequencing; proteomic; lipidomic; metabolomic; therapy; biomarker; animal and organoid model

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antioxidants: The Molecular Guardians Against Oxidative Stress

edited by

Karolina A. Wojtunik-Kulesza

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4507 | Submission Open

Keywords: antioxidant; free radical; oxidative stress; essential oils; secondary plant metabolites

(This special issue belongs to the Section Biochemistry)

MicroRNAs and Other Non-Coding RNAs as Regulators, Biomarkers, and Therapeutic Targets, 2nd Edition

edited by

Wan Lee

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4431 | Submission Open

Keywords: non-coding RNAs; microRNA; lncRNA; circRNA; piRNA; biomarker; therapeutic target

(This special issue belongs to the Section Molecular Biology)

Biological and Molecular Aspects of Exercise Adaptation

edited by

Alessandra Modesti

submission deadline 20 Apr 2026 | 4 articles | Viewed by 4404 | Submission Open

Keywords: exercise; redox homeostasis; metabolic state; biological; physiological

(This special issue belongs to the Section Molecular Biology)

Advancing Regenerative Medicine: Basic Research and Translation in Clinics

edited by

Dragan Primorac

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4396 | Submission Open

Keywords: regenerative medicine; stem cells; tissue engineering; exosomes; orthobiologics

(This special issue belongs to the Section Molecular Biology)

The Roles of Phytochemicals and Antioxidants in Colon Cancers

edited by

Nunzio Antonio Cacciola

Francesca Borrelli

and

Paola De Cicco

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4392 | Submission Open

Keywords: colon cancer; colorectal cancer; natural products; drug-resistant; phytochemicals; antioxidants; cellular and molecular mechanisms; anti-cancer activity; prevention; treatments

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Anxiety and Depression: Pathomechanisms and Therapeutic Strategies

edited by

Magdalena Sowa-Kućma

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4298 | Submission Open

Keywords: anxiety; depression; anxiolytics; antidepressants; animal models

(This special issue belongs to the Section Molecular Neurobiology)

Role of Mutations and Polymorphisms in Various Diseases: 2nd Edition

edited by

Anna Cieślińska

submission deadline 20 Apr 2026 | 4 articles | Viewed by 4297 | Submission Open

Keywords: nutrigenomics; polymorphism; SNPs; mutations; predisposition; correlation; diversity; deletion; insertion

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Insights in Biomarkers of Autoimmune and Autoinflammatory Diseases: 2nd Edition

edited by

Mariapaola Marino

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4292 | Submission Open

Keywords: inflammaging; inflammasome; autoantibodies; free light chains; cytokines; receptor; signal transduction; innate immunity; adaptive immunity

(This special issue belongs to the Section Molecular Immunology)

Lifestyle Interventions in MASLD: Molecular and Clinical Perspectives

edited by Muhammad Y. Sheikh

submission deadline 20 Apr 2026 | 1 articles | Viewed by 4259 | Submission Open

Keywords: NAFLD (nonalcoholic fatty liver disease); MASLD (metabolic syndrome-associated steatotic liver disease); metabolic syndrome; dyslipidemia; diabetes mellitus 2; hypertension; natural bioactive

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Amyotrophic Lateral Sclerosis Behind Motor Neurons

edited by

Patrizia Longone

and Ezia Guatteo

submission deadline 20 Apr 2026 | 1 articles | Viewed by 4216 | Submission Open

Keywords: non-neuronal cells; neurotransmitters; systemic disease; motor system; neuronal circuitry; skeletal muscle metabolism; muscle oxidative metabolism

(This special issue belongs to the Section Molecular Neurobiology)

Novel Insights into Bone Tissue: Pathologies and Therapeutic Strategies

edited by

Francesca Salamanna

submission deadline 20 Apr 2026 | 1 articles | Viewed by 4215 | Submission Open

Keywords: bone tissue; pathologies; regenerative medicine; biomechanics; diagnostics; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurogenesis and Neurodegeneration: Insights into Regeneration and the Impact of Neurotrophins

edited by

Eva Terzibasi Tozzini

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4181 | Submission Open

Keywords: neurogenesis; neurodegeneration and regeneration; neurotrophins; brain plasticity

(This special issue belongs to the Section Molecular Neurobiology)

New Insights in the Mechanism of Obstetrical Complications: Prevention, Diagnosis, Monitoring, Treatment

edited by

Lucia Maria Procopciuc

and

Roxana Liana Lucaciu

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4176 | Submission Open

Keywords: high blood pressure; gestational diabetes; infections; preeclampsia; eclampsia; preterm labor; depresion; anxiety; pregnancy loss/miscarriage; stillbirth; premature membrane rupture; vaginal bleeding; placenta previa; anemia; intrauterine growth restriction; maternal risk factors; fetal risk factors; endothelial dysfunction; angiogenesis; oxidative stress; hormonal modifications; dyslipidemia; biochemical; genetic; epigenetic determinations; computational analysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antitumor Activity of Natural Products

edited by

Spiro Mihaylov Konstantinov

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4169 | Submission Open

Keywords: natural compounds and extracts with antitumor activity; studies on molecular mechanisms; signal transduction modulation in tumor cells; immunomodulating activity; mitosis inhibition; cell differentiation; cell death induction (apoptosis/autophagy)

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Therapies, Pathogenetic and Inflammatory Mechanisms in Thrombosis

edited by

Matteo Becatti

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4162 | Submission Open

Keywords: thromboinflammation; endothelial dysfunction; antithrombotic therapies; oxidative stress; thrombosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular and Physiological Responses of Insects to Biotic, Abiotic and Xenobiotic Constraints

edited by

Farman Ullah

Shuo Yan

and Yaobin Lu

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4156 | Submission Open

Keywords: climatic changes; chemical insecticides; insect adaptation mechanisms; resistance mechanisms; ecosystem services; insect ecology; thermal stress adaptations

(This special issue belongs to the Section Molecular Biology)

Amyotrophic Lateral Sclerosis: From Molecular Basis to Therapies

edited by

Matteo Bordoni

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4016 | Submission Open

Keywords: ALS; pathomechanisms; genetics; epigenetics; disease models; neuroinflammation; mithocondria; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Lung Inflammation, Injury, and Repair (Second Edition)

edited by

Andreas Schwingshackl

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3972 | Submission Open

Keywords: lung; inflammation; injury; repair; fibrosis; diagnostics; therapeutics; acute respiratory distress syndrome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chitosan Materials: Recent Advances in Modification, Properties and Application

edited by

Gabriela Dudek

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3931 | Submission Open

Keywords: chitosan materials; biomedical applications; agriculture and food industry; water treatment and environmental applications; nanotechnology and advanced materials

(This special issue belongs to the Section Macromolecules)

Latest Review Papers in Molecular Immunology, 3rd Edition

edited by

Manlio Ferrarini

and

Vincenzo Barnaba

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3916 | Submission Open

Keywords: molecular immunology; review; immune cells

(This special issue belongs to the Section Molecular Immunology)

The Role of Long Non-Coding RNAs in Stress and Diseases

edited by

Antonis Giannakakis

and

Vladimir A. Kuznetsov

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3718 | Submission Open

Keywords: long non-coding RNAs (lncRNAs); human health; core stress response; genotoxic stress; exosomes; biomarkers; stress-related diseases; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cyclodextrins: Properties and Applications, 3rd Edition

edited by

Miguel A. Esteso

and

Carmen M. Romero

submission deadline 20 Apr 2026 | 5 articles | Viewed by 3716 | Submission Open

Keywords: cyclodextrins; controlled release systems; structure modification; thermodynamic properties; transport properties

(This special issue belongs to the Section Macromolecules)

Structural and Functional Insights into Membrane Transporters: A Tribute to Dr. Ernest Wright

edited by Jeff Abramson

submission deadline 20 Apr 2026 | 3 articles | Viewed by 3694 | Submission Open

Keywords: membrane transporters; membrane protein; glucose transport; cell membrane; interface reaction

(This special issue belongs to the Section Molecular Biology)

Molecular Diagnosis and Treatments of Diabetes Mellitus: 2nd Edition

edited by

Mihail Virgil Boldeanu

submission deadline 20 Apr 2026 | 4 articles | Viewed by 3693 | Submission Open

Keywords: metabolic disorders; diabetes mellitus; inflammation; neurotransmitter; inflammatory biomarkers; molecular target; molecular diagnostics; therapeutics; insulin resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds of Natural Origin: 2nd Edition

edited by

Katarzyna Pacyga

submission deadline 20 Apr 2026 | 5 articles | Viewed by 3595 | Submission Open

Keywords: plants; extraction methods; bioactive compounds; natural products; application

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Latest Advances in Cytokine Storm

edited by

Raymond Kaempfer

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3592 | Submission Open

Keywords: cytokine storm; cytokine release syndrome; inflammatory; protective immunity; multi-drug resistant bacterial strains

(This special issue belongs to the Section Molecular Immunology)

New Insights into Osteoclasts

edited by

David Gyori

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3568 | Submission Open

Keywords: osteoclast; bone remodeling; osteoporosis; inflammatory arthritis; bone tumor

(This special issue belongs to the Section Molecular Biology)

Role of Extracellular Vesicles in Immunology: Second Edition

edited by

Paolo Colombo

and Valeria Longo

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3565 | Submission Open

Keywords: extracellular vesicles; exosomes; microvesicles; apoptotic bodies; cytokines; immunological response; immune system

(This special issue belongs to the Section Molecular Immunology)

Molecular Basis and Treatment of Skin Diseases and Their Associated Complications (2nd Edition)

edited by

Maria Maisto

and

Vincenzo Piccolo

submission deadline 20 Apr 2026 | 3 articles | Viewed by 3511 | Submission Open

Keywords: diagnosis; biomarkers; imaging; histopathology; cutaneous comorbidities complication; therapy; management; clinical Trials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 2401-2450 on page 49 of 67.

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