Germline Stem Cells: New Insights
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 August 2025 | Viewed by 3965
Special Issue Editor
Special Issue Information
Dear Colleagues,
Germline stem cells represent a significant focus of scientific research due to their vital role in reproduction and inheritance. These unique cells produce gametes, essential for passing on genetic information from generation to generation. Significant advances in the study of germline stem cells have provided valuable insights into their development, regulation, and potential medical applications. Research has uncovered complex molecular mechanisms that govern the maintenance and differentiation of germline stem cells. These findings have enhanced our understanding of fundamental biological processes and opened up potential new approaches to addressing infertility and genetic disorders.
This Special Issue aims to gather cutting-edge research and comprehensive reviews showcasing the latest discoveries and technological advancements in this rapidly evolving field. Areas of focus include, but are not limited to, the identification of new markers for germline stem cells, the impact of the microenvironment on stem cell behavior, the regulation of gene expression through epigenetic mechanisms, and the implications of manipulating germline stem cells in regenerative medicine. This Special Issue will specifically highlight studies employing microarray analysis, single-cell sequencing, the discovery of key signaling pathways, and spatial genomics. Particular emphasis will be placed on the study of spermatogonia and oocyte development and the use of bioinformatics to understand germline stem cell biology. By consolidating groundbreaking research from leading experts, this Special Issue will deepen our understanding of germline stem cell biology and inspire innovative strategies to address reproductive health issues and genetic diseases.
Prof. Dr. Thomas Skutella
Guest Editor
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Keywords
- signaling pathway
- spermatogonia development
- oocyte development
- microarray analysis
- single-cell sequencing
- epigenetic mechanisms
- germline stem cell
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