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Molecular Perspectives in Nanomedicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 3320

Special Issue Editor

Special Issue Information

Dear Colleagues,

Nanomedicine is a new interdisciplinary branch of science enabling the development of novel nano-systems for therapy and diagnosis. New advancements in the development of novel nanocarriers and/or new diagnostic tools in the near future are envisaged due to the strong engagement of several groups around the world. The publication of original research articles and comprehensive reviews will foster the scientific progress in emerging areas like immune-nanomedicine, nano-fluidic diagnostic tools, polymeric and hybrid NPs, and CAR-T nanotechnologies, among others. This Special Issue will enable further study into the molecular bases of such technologies and the future applications of such new nano-tools in clinical praxis.

Prof. Dr. Stefano Leporatti
Guest Editor

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Keywords

  • nanomedicine
  • drug delivery
  • nano therapy and diagnostics
  • micro and nanofluidic tools
  • hybrid nanoparticles
  • CAR-T nanotechnologies

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Published Papers (1 paper)

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Research

24 pages, 4942 KiB  
Article
DIA/SWATH-Mass Spectrometry Revealing Melanoma Cell Proteome Transformations with Silver Nanoparticles: An Innovative Comparative Study
by Simona Martano, Jakub Faktor, Sachin Kote, Mariafrancesca Cascione, Riccardo Di Corato, Dagmar Faktorova, Paola Semeraro, Loris Rizzello, Stefano Leporatti, Rosaria Rinaldi and Valeria De Matteis
Int. J. Mol. Sci. 2025, 26(5), 2029; https://doi.org/10.3390/ijms26052029 - 26 Feb 2025
Viewed by 2730
Abstract
Melanoma is an aggressive cancer with rising incidence and high mortality rates, largely due to chemotherapy resistance and molecular dysregulation. Nanotechnology, particularly silver nanoparticles (AgNPs), has emerged as a promising therapeutic avenue because of the nanoparticles’ ability to induce oxidative stress and apoptosis [...] Read more.
Melanoma is an aggressive cancer with rising incidence and high mortality rates, largely due to chemotherapy resistance and molecular dysregulation. Nanotechnology, particularly silver nanoparticles (AgNPs), has emerged as a promising therapeutic avenue because of the nanoparticles’ ability to induce oxidative stress and apoptosis in cancer cells. However, conventional colloidal AgNPs lack selectivity, often causing significant damage to healthy cells. In this study, we introduce a green synthesis of AgNPs using plant extracts, providing an eco-friendly alternative with improved antitumor selectivity compared to traditional colloidal AgNPs. Leveraging label-free Data-Independent Acquisition/Sequential Window Acquisition of All Theoretical Mass Spectrometry (DIA/SWATH MS) quantitative proteomics, we investigated the antitumor effects of green-synthesized versus traditional AgNPs on A375 melanoma cells at 24 and 48 h. Our findings reveal that green AgNPs selectively reduced melanoma cell viability while sparing healthy keratinocytes (HaCaT), a benefit not observed with colloidal AgNPs. Proteomic analysis highlighted that green AgNPs significantly downregulated oncogenes, enhanced carbohydrate metabolism, and disrupted copper homeostasis in melanoma cells. This marks the first study to explore the differential effects of green and traditional AgNPs on melanoma using an integrated proteomic approach, underscoring the molecular potential of green AgNPs as a targeted and sustainable option for cancer therapy. Full article
(This article belongs to the Special Issue Molecular Perspectives in Nanomedicine)
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