Molecular Targets and Immunotherapy for Autoimmune Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 2249
Special Issue Editor
Special Issue Information
Dear Colleagues,
Autoimmune diseases are chronic pathological conditions resulting from a dysregulated immune response that fails to recognize self-antigens. Genetic predisposition and environmental factors contribute to the initiation of autoimmunity, ultimately leading to long-term tissue destruction. Conventional treatments of autoimmune diseases often rely on suppressing the general immune functions to control inflammation. However, these approaches are not entirely successful as non-selective immune suppression leads to inadvertent side effects, particularly the risk of developing infection. Recent advancements in genetic engineering tools resulted in the development of more targeted immunotherapies, such as cytokine-based (anti-TNFa, IL1b, IL6, and IL-17), cell-targeted therapies (anti-CD20 mAb, CTLA4-IgG1, etc.), and small-molecule inhibitors (JAK1/2/3, Tyk2, and BTK). Currently, antigen-specific immunotherapies utilizing more specific CAR T cells are beginning to emerge; however, their efficacy and long-term safety in a heterogenous population remains to be determined.
In this Special Issue, we aim to provide a comprehensive overview of the pathophysiological mechanisms of autoimmune diseases. We welcome manuscripts that address the deeper signaling pathways with the purpose of identifying novel molecular targets in autoimmune diseases. In this Special Issue, we give special emphasis to emerging targeted immunotherapies that can provide effective, safe, and long-term immune tolerance. We encourage the submission of review articles as well as original research papers.
Dr. Neetu Srivastava
Guest Editor
Manuscript Submission Information
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Keywords
- autoimmunity
- autoimmune diseases
- immunotherapy
- signaling pathway
- molecular targets
- antibody
- T cells
- B cells
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