False-Positive and False-Negative Laboratory Biomarkers
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 2008
Special Issue Editors
Interests: cardiovascular
Interests: microbe-host interactions; biofilms and antibiotic resistance; implant-associated infections; microbiome research
Special Issue Information
Dear Colleagues,
Biomarkers play a crucial role in the diagnosis and management of various diseases. For example, in oncology, mutations such as EGFR, KRAS, and BRAF serve as vital indicators for targeted therapies. Additionally, for cardiovascular diseases, markers such as hs-CRP, BNP, NT-proBNP, and troponin I/T provide insights into heart function and disease severity. In neurology, the presence of Aβ42, tau proteins, and neurofilament light chain (NFL) is indicative of neurodegenerative disorders. Autoimmune conditions can be assessed through antibodies like ANA, dsDNA, and anti-CCP, while infectious diseases often rely on CRP, PCT, and specific viral antibodies or nucleic acids for diagnosis. However, the accuracy of biomarker detection is influenced by a complex interplay of factors, which can lead to false-positive and false-negative results.
This Special Issue aims to explore the underlying molecular mechanisms that contribute to these inaccuracies, providing a theoretical foundation for improving biomarker reliability and advancing clinical practice.
To achieve this goal, we invite original research articles, reviews, case reports, and meta-analyses that specifically investigate the factors contributing to false-positive and false-negative results in biomarker detection. This includes exploring the impact of sample pre-processing techniques, analytical methodologies, and biomolecular modifications on assay performance. We also encourage submissions that examine how genomic variations, epigenetic alterations, and microenvironmental conditions can influence biomarker expression and detection accuracy. Furthermore, studies that evaluate the effectiveness of multi-omics approaches, liquid biopsy technologies, and single-cell sequencing in reducing diagnostic errors and enhancing the reliability of biomarkers are particularly welcome.
Dr. Michela Salvatici
Dr. Lorenzo Drago
Guest Editors
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Keywords
- biomarkers
- false positives/negatives
- protein biomarkers
- nucleic acid markers
- multi-omics
- single-cell sequencing
- liquid biopsy
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