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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Endocrinology of Pregnancy

edited by

Georgios Valsamakis

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2587 | Submission Open

Keywords: pregnancy; endocrine system; fetal development; maternal health; metabolism

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research on Kidney Disease/Renal Dysfunction

edited by

Hiroshi Nonoguchi

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2581 | Submission Open

Keywords: kidney disease/renal dysfunction; hypoxia-inducible factor-prolyl hydroxylase (HIF-PHD) inhibitors; renal anemia; chronic renal faikure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Medicinal Plant Resources—from Molecular Studies to Sustainable Use

edited by Ekaterina Kozuharova

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2579 | Submission Open

Keywords: genetic improvement of medicinal plants; sustainable use; bioactive compounds

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Protein Structure-Function and Drug Discovery

edited by Francesc Xavier Avilés and F. Xavier Gomis-Rüth

submission deadline 20 Mar 2026 | 3 articles | Viewed by 2566 | Submission Open

Keywords: protein structure; protein function; protein drug target; inhibition; protein structure-function; protein drug discovery; protein inhibition; protein activation; protein regulation; protein structure-function and evolution; protein structure-function engineering and design; protein structure-function and drug discovery

(This special issue belongs to the Section Macromolecules)

P53 and Tumours: Strategies to Overcome Chemoresistance in a p53-Dependent Way

edited by

Mariano Francesco Caratozzolo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2563 | Submission Open

Keywords: P53; chemoresistant tumours; drug design; regulatory RNAs; drugs targeting; NGS; transcriptional regulation; molecular networks

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oxidative Stress and Autophagy in Cancer Cells

edited by

Abdelhabib Semlali

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2512 | Submission Open

Keywords: oxidative stress; autophagy; apoptosis; cancer cells; cancer cell signaling pathways

(This special issue belongs to the Section Molecular Biology)

Cutaneous Biology, Molecular Dermatology and Dermatopathology, 2nd Edition

edited by

Bijan Safai

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2486 | Submission Open

Keywords: molecular dermatology; targeted therapy; cutaneous oncology; immunodermatology; cutaneous biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Female Reproductive Physiology

edited by Tomoko Fujiwara and

Masanori Ono

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2401 | Submission Open

Keywords: circadian rhythm; diet; hypothalamus; lifestyle habits; ovary; pituitary; preconception care; reproduction function; reproductive behavior; uterus

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Epigenetic Mechanisms in Cognition

edited by Sabrina Venditti

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2371 | Submission Open

Keywords: epigenetics; DNA methylation; histone modifications; noncoding RNAs; cognition; learning and memory; neuroplasticity; neurodegeneration; ASD; training

(This special issue belongs to the Section Molecular Biology)

New Advances in the Field of Thrombosis and Hemostasis

edited by

Claudia Maria Radu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2320 | Submission Open

Keywords: bleeding; thrombosis; new diagnostic tests; rare diseases; platelet function; biomarkers; risk factors; thrombocytopenia; endothelial dysfunction; autoantibodies; extracellular vesicles; stem cells; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Insights into Reproductive Toxicology

edited by Maria Cristina Budani

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2303 | Submission Open

Keywords: endocrine disruptors; environmental toxicants; fertility; heavy metals; lifestyle habits; molecular mechanisms; pregnancy; teratology; teratogenic compounds; reproductive toxicology

(This special issue belongs to the Section Molecular Toxicology)

Microbial Genomics in the Omics Era

edited by

Surajit De Mandal

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2268 | Submission Open

Keywords: microbe; bioinformatics; DNA; RNA; protein; sequencing; structure; omics

(This special issue belongs to the Section Molecular Microbiology)

Biomechanics of Cardiovascular Remodeling

edited by

Kevin Willy

and Maximilian Doldi Philipp

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2136 | Submission Open

Keywords: cardiovascular remodeling; cardiac imaging; cardiovascular intervention; cardiovascular pathways; cardiovascular research; structural heart disease; cellular signaling

(This special issue belongs to the Section Molecular Biophysics)

Drugs Targeting Cancer Signaling Pathways: Dissecting Mechanisms to Unlock New Therapeutic Targets

edited by Souleymane Abdoul-Azize

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2134 | Submission Open

Keywords: small-molecule drugs; signal transduction; therapeutic targets; therapeutic resistance; oncogenic signaling; novel biomarkers; cancer therapy; cancer signaling pathways; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

The Role and Mechanisms of Natural Products in Inflammatory Responses and Inflammatory Diseases

edited by

Young-Su Yi

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2097 | Submission Open

Keywords: natural product; bioactive component; inflammation; inflammatory disease; anti-inflammatory; mechanism

(This special issue belongs to the Section Molecular Immunology)

Molecular Pharmacology and Interventions in Cardiovascular Disease: 2nd Edition

edited by

Magdalena Zabielska-Kaczorowska

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2027 | Submission Open

Keywords: cardiovascular pharmacology; cardiovascular interventions; cardioprotection; myocardial ischemia and infarction; heart failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms Underlying the Pathogenesis of Genetic Diseases

edited by

Debora Baroni

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2020 | Submission Open

Keywords: genetic diseases; genotype– phenotype correlations; multi-omics approaches; current and investigational therapeutical approaches; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Recent Molecular Basis of Neurocognitive Mechanism

edited by

Poppy Schoenberg

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2013 | Submission Open

Keywords: cognitive functioning; epigenomics; high-throughput omics; metabolomics; molecular pathways; multi-modal datasets; neurocognition; neurodegeneration; neurorehabilitation; proteomics; transcriptomics

(This special issue belongs to the Section Molecular Neurobiology)

3D Technology in Biomedicine: Studying Molecular Mechanisms in Health and Disease

edited by Flavia Carton

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1996 | Submission Open

Keywords: 3D technologies; biomedicine; molecular biology; in vitro/ex vivo models; regenerative medicine; human diseases

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms of Mitochondrial Neurodegenerative Diseases

edited by

Matteo Calcagnile

and Paola Pontieri

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1953 | Submission Open

Keywords: mitochondrial disease; nuclear genome; mitochondrial genome; human MRP genes; MRPL44; NAM9; GEP3; Alzheimer’ s disease; Parkinson’ s disease; yeast and C. elegans model organisms

(This special issue belongs to the Section Molecular Neurobiology)

Targeting MAPK in Human Diseases

edited by

Elisabetta Rovida

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1948 | Submission Open

Keywords: ERK; DUSP; cancer; inflammation; neurodegenerative diseases; autoimmune diseases; targeted therapy; cell signaling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Macrophages in Tumors

edited by

Julia Kzhyshkowska

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1947 | Submission Open

Keywords: tumor-associated macrophages; transcriptome; metabolome; epigenetics; angiogenesis; metastasis; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

The Role of Lipids in Human Health

edited by

Angela Maria Rizzo

and Irma Colombo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1941 | Submission Open

Keywords: lipids; lipidomics; fatty acids; sphingolipids; steroids; metabolism

(This special issue belongs to the Section Biochemistry)

Dialogue Between Inflammation and Immunity: From Mechanism to Therapy

edited by

Nikolina Mihaylova

submission deadline 20 Mar 2026 | 3 articles | Viewed by 1926 | Submission Open

Keywords: inflammation; immune activation; immunomodulation; tolerance; immunotherapy; autoimmune diseases; cancer

(This special issue belongs to the Section Molecular Immunology)

Environmental Sensitivity Illnesses: Advances in Mechanisms and Molecular Signatures

edited by

Daniela Caccamo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1923 | Submission Open

Keywords: electromagnetic hypersensitivity; multiple chemical sensitivity; fibromyalgia; chronic fatigue syndrome; chronic pain disorder; toxicant-induced loss of tolerance; total allergy syndrome; circulating biomarkers; genetic susceptibility factors; immune system alterations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in New Biomarkers for Cancers

edited by

Maria Panagopoulou

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1909 | Submission Open

Keywords: biomarkers; cancer research; liquid biopsy; epigenetic and genetic biomarkers; precision oncology; diagnosis; prognosis; prediction

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathogenesis and Therapeutic Innovations in Oral Diseases

edited by Tatsuji Nishihara

submission deadline 20 Mar 2026 | 3 articles | Viewed by 1893 | Submission Open

Keywords: molecular-based analysis; diagnosis of oral disease; oral disease treatment; regeneration therapy; drug therapy; periodontitis; implantitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Approaches to Enhancing Bioavailability and Bioaccessibility of Bioactive Compounds from Plant and Food Extracts

edited by

Ana-Maria Vlase

submission deadline 20 Mar 2026 | 3 articles | Viewed by 1870 | Submission Open

Keywords: bioactive compounds; nutraceuticals; functional foods; in vitro and in vivo models; bioavailability; bioaccessibility; nanotechnology; delivery systems; molecular mechanisms; proteomics; genomics; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exploring Organic Compounds in Photodynamic Therapy: Synthesis, Mechanism of Action and Biological Potential

edited by

Maria G. P. M. S. Neves

Nuno M. M. Moura

and

Catarina I. V. Ramos

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1822 | Submission Open

Keywords: organic photosensitizers; photodynamic therapy; synthetic strategies; mechanism of action; cancer cells; microorganisms

(This special issue belongs to the Section Biochemistry)

Mechanisms and Effects of Endocrine Disruptors and Environmental Contaminants on Human Health

edited by

Margarida Lorigo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1810 | Submission Open

Keywords: environmental exposure; emerging compounds; human health; risk assessment; adverse outcome pathway; new approach methodologies; one health

(This special issue belongs to the Section Molecular Toxicology)

Recent Advances in Bioactive Compounds in Human Health

edited by

Dorota Gumul

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1767 | Submission Open

Keywords: bioactive compounds; antioxidants; food by-products; functional foods; innovative food technologies; molecular food science

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Thyroid Function in Human Diseases: From Physiopathology to Clinical Impact on Human Health

edited by

Rosa Maria Paragliola

and Andrea Corsello

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1738 | Submission Open

Keywords: thyroid physiology; hypothyroidism; hyperthyroidism; central hypothyroidism; inappropriate TSH secretion syndrome; drugs interfering with thyroid function; sick euthyroid syndrome; consumptive hypothyroidism syndrome

(This special issue belongs to the Section Molecular Biology)

Novel Nanoparticle Composites: Functionalization and Application

edited by

Jovan M. Nedeljković

and

Vesna Lazić

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1710 | Submission Open

Keywords: nanoparticles; nanocomposites; synthesis; functionalization; interface; photocatalysis; antimicrobial nanoparticles; nanomedicine; theoretical modelling; computer simulations

(This special issue belongs to the Section Molecular Nanoscience)

Bioconjugates and Application

edited by

Gábor Mező

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1707 | Submission Open

Keywords: bioconjugates; targeted therapy; homing moieties; drug delivery; bioconjugates as diagnostic tools; targeted nanoparticles; antibody– drug conjugates; linkage systems

(This special issue belongs to the Section Macromolecules)

Recent Research of Protein Structure Prediction and Design

edited by

Alexandre G. De Brevern

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1664 | Submission Open

Keywords: protein design; multidomain proteins; AlphaFold2; protein folding; deep learning

(This special issue belongs to the Section Biochemistry)

Advancements in Pathogen Detection, Microdevice Technologies and AI-Driven Analysis

edited by

Younseong Song

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1649 | Submission Open

Keywords: pathogen detection; microfluidic; microdevice; AI analysis; virus; bacteria; point-of-care testing; infectious disease; nanotechnology

(This special issue belongs to the Section Molecular Biology)

New Insights into Epilepsy: From Molecular Physiology to Pathology

edited by Paolo Mainardi

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1637 | Submission Open

Keywords: epilepsy; molecular pathology; disease; therapeutic strategies; celluar advance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Cancer Stem Cells

edited by

Ilze Štrumfa

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1551 | Submission Open

Keywords: cancer stem cells; tumour microenvironment; pancreatic cancer; glioblastoma; gastric cancer; breast cancer; lung cancer; colorectal cancer; renal cancer; liver cancer; melanoma; leukemia; lymphoma

(This special issue belongs to the Section Molecular Oncology)

Molecular Diagnosis and Targeted Therapies in Ischemic Stroke

edited by Alicia Aliena-Valero and María Castelló-Ruiz

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1549 | Submission Open

Keywords: ischemic stroke; cerebral protection; repair treatments; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Research of Kidney Diseases

edited by Andrea Angioi

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1529 | Submission Open

Keywords: molecular genetics; kidney disease; biomarkers; cellular signaling; target therapeutics; innovative treatments

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Nanomedicines Against Bacterial Infections

edited by

Stephanie Andrade

, Nuno Guimarães,

Maria João Ramalho

and

Joana A. Loureiro

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1527 | Submission Open

Keywords: nanotechnology; nanoparticle; nanocarriers; nanoantibiotic; drug delivery system; targeted delivery; theranostic; infectious diseases; antibacterial agent; antimicrobial resistance; biomedical application

(This special issue belongs to the Section Molecular Nanoscience)

Novel Statistical Methods in Gene Expression Analysis, Functional Genomics, Genetics, and Biochemistry

edited by Łukasz Huminiecki

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1499 | Submission Open

Keywords: multi-omics; statistics; gene expression analysis

(This special issue belongs to the Section Molecular Informatics)

Green Chemical Pesticide Design, Synthesis and Evaluation

edited by Ranfeng Sun

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1462 | Submission Open

Keywords: green pesticides; natural products; action mechanism of pesticides; synthesis

(This special issue belongs to the Section Biochemistry)

Cotton Molecular Genomics and Genetics (Third Edition)

edited by

Jie Sun

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1448 | Submission Open

Keywords: cotton; biotic or abiotic stress; disease resistance; fiber yield and quality; gene editing; gene identification and function validation; genome-wide association study; QTL identification

(This special issue belongs to the Section Molecular Plant Sciences)

Mechanism of Cellular Signaling, Dysfunction, and Drug Effects on Alzheimer's Disease

edited by

Eva Kiss

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1413 | Submission Open

Keywords: AD; targeted therapy; Alzheimer's disease; neurodegenerative disease; tau protein

(This special issue belongs to the Section Molecular Neurobiology)

Nanostructures: From Synthesis, Modification to Biomedical Applications

edited by Kleoniki Giannousi and

Catherine Dendrinou-Samara

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1351 | Submission Open

Keywords: nanostructures; post-synthetic methods; multi-drug resistant bacteria; amyloidopathies; neurodegeneration; photocatalysis; biosensors

(This special issue belongs to the Section Molecular Nanoscience)

Solanaceae Biology: From Genetics to Metabolism

edited by

Pengxiang Fan

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1314 | Submission Open

Keywords: Solanaceae; nightshade family; tomato; potato; tobacco; eggplant; genetics; metabolism; crop improvement; specialized metabolite

(This special issue belongs to the Section Molecular Plant Sciences)

Mechanistic Insights into Pharmacological and Non-Pharmacological Pain Therapies: From Cellular Responses to Therapy Outcomes

edited by

Sungtae Koo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1312 | Submission Open

Keywords: neuromodulation; neural plasticity; glial activation; endogenous pain modulation; neuroinflammation; therapeutic mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Gene Function, Molecular Mechanisms, and Crop Breeding

edited by Hongwei Lu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1303 | Submission Open

Keywords: molecular biology; gene function; molecular mechanism; crop breeding; molecular biology; agronomic traits; gene discovery; genomics; bioinfomatics; gene regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Metabolism in Human Health and Disease

edited by

Abdelnaby Khalyfa

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1224 | Submission Open

Keywords: molecular metabolism; metabolic pathways; insulin resistance; Warburg effect; chronic disease; metabolomics; precision medicine; metabolic dysfunction; cancer metabolism; personalized nutrition; enzyme-targeted therapy; systems biology; cellular energy; metabolic health; preventative healthcare

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

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