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The Role and Mechanisms of Natural Products in Inflammatory Responses and Inflammatory Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 1326

Special Issue Editor

Special Issue Information

Dear Colleagues,

Inflammation is an innate immunity to protect the body from pathogens and cellular danger signals; however, repeated and prolonged inflammation, known as chronic inflammation, has been considered a critical risk factor for human diseases. Therefore, much effort has been made to understand the mechanisms of inflammatory responses and develop anti-inflammatory therapeutics. Many anti-inflammatory drugs have been developed, but the critical limitations of these drugs are considerable toxicity with limited efficacy. Natural products and their bioactive components have long been used to enhance human health and to alleviate a variety of pathogenic conditions, suggesting that natural products are safe and efficacious for numerous human diseases. However, the regulatory roles of natural products in inflammatory responses and diseases and the underlying mechanisms remain largely unknown.

This Special Issue welcomes studies that explore, but are not limited to, the following areas: the regulatory roles of natural products and their bioactive components in inflammatory responses and diseases, identifying and validating novel targets regulating inflammatory responses, evaluating anti-inflammatory effects of natural products, and developing natural product-based anti-inflammatory therapeutics.

Dr. Young-Su Yi
Guest Editor

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Keywords

  • natural product
  • bioactive component
  • inflammation
  • inflammatory disease
  • anti-inflammatory
  • mechanism

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Published Papers (1 paper)

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Review

17 pages, 2966 KiB  
Review
Regulatory Roles of Noncanonical Inflammasomes in Inflammatory Lung Diseases
by Young-Su Yi
Int. J. Mol. Sci. 2025, 26(1), 27; https://doi.org/10.3390/ijms26010027 - 24 Dec 2024
Cited by 1 | Viewed by 852
Abstract
The inflammatory response consists of two stages: priming and triggering. The triggering stage is marked by the activation of inflammasomes, which are cytosolic protein complexes acting as platforms for inflammation. Inflammasomes are divided into canonical and noncanonical categories. Inflammatory lung diseases such as [...] Read more.
The inflammatory response consists of two stages: priming and triggering. The triggering stage is marked by the activation of inflammasomes, which are cytosolic protein complexes acting as platforms for inflammation. Inflammasomes are divided into canonical and noncanonical categories. Inflammatory lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), inflammatory lung injury, and pulmonary fibrosis arise from lung inflammation and damage. While the role of canonical inflammasomes in these diseases is well demonstrated, recent findings emphasize the critical roles of noncanonical inflammasomes in regulating inflammation and various inflammatory conditions. Particularly, new studies highlight their involvement in inflammatory lung diseases. This review delves into recent research on the regulatory roles of noncanonical inflammasomes, such as human caspase-4 and murine caspase-11, in lung inflammation and the development of inflammatory lung diseases, as well as the potential for targeting these inflammasomes for new treatments. Full article
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