Dialogue Between Inflammation and Immunity: From Mechanism to Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 52
Special Issue Editor
Interests: autoimmunity; osteoarthritis; B cells; T cells; cell signaling; mouse models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The dynamic dialogue between inflammation and the immune system is essential for health and disease management. Inflammation is vital for pathogen clearance and tissue repair but can also contribute to chronic disease when dysregulated. The immune system orchestrates inflammation as a defensive mechanism to combat infections and tissue injury. The interplay between immune cells, cytokines, and signaling pathways governs the balance between protective and pathological inflammation.
Chronic inflammation underlies many autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and multiple sclerosis (MS). Dysregulated cytokine production, loss of immune tolerance, and persistent activation of autoreactive lymphocytes drive tissue damage in these conditions. Inflammation is a key component of the tumor microenvironment, influencing cancer initiation, progression, and metastasis. Pro-inflammatory cytokines such as IL-6 and TNF-α promote tumor growth, angiogenesis, and immune evasion. In contrast, immune checkpoint pathways (e.g., PD-1/PD-L1) facilitate tumor-induced immunosuppression. The metabolic disorders and cardiovascular diseases are also supported by chronic inflammation.
A deeper understanding of the intricate mechanisms underlying the interplay between inflammation and immunity is vital for developing innovative treatments, paving the way for personalized and effective therapies in immune-related diseases.
This Special Issue will offer a collection of cutting-edge research articles or reviews that explore molecular crosstalk between inflammation and immunity, elucidate the mechanisms underlying their regulation, and discuss emerging therapeutic strategies aimed at modulating these interactions for clinical benefit.
Dr. Nikolina Mihaylova
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- inflammation
- immune activation
- immunomodulation
- tolerance
- immunotherapy
- autoimmune diseases
- cancer
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
