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Biomechanics of Cardiovascular Remodeling

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".

Deadline for manuscript submissions: closed (31 July 2025) | Viewed by 940

Special Issue Editors


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Guest Editor
Department of Cardiology II & III, University Hospital of Münster, Albert-Schweitzer-Campus 1, 48149 Münster, Germany
Interests: implantable cardioverter defibrillators; defibrillation; sudden cardiac death; catheter ablation; cardiac electrophysiologic; risk stratification for sudden cardiac death; biomarkers for development or progression of cardiac diseases
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Guest Editor
Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Munich, Germany
Interests: heart failure; chronic heart failure; clinical cardiology; clinical research

Special Issue Information

Dear Colleagues,

The current Special Issue aims at highlighting new scientific evidence in the field of cardiovascular remodeling, including all aspects of its underlying mechanisms and clinical outcomes.

Cardiac remodeling is a crucial key process in understanding and positively influencing the course of cardiovascular diseases. Most pharmaceutical therapies aim at altering signaling pathways in order to positively influence cardiac remodeling. However, many of the underlying mechanisms remain to be elucidated.

Manuscripts on biomechanical, biochemical, and biophysical mechanisms leading to cardiovascular remodeling and its subsequent unfavorable outcome are equally welcome as studies on trials on pharmacological or interventional (e.g., PCI, device therapy, structural interventions) influences on cardiac remodeling. Furthermore, models predicting unfavorable or favorable remodeling, e.g., using AI, are suitable as well. The same is true for studies including cardiac imaging illustrating cardiac remodeling and its consequences.

We strongly encourage all manuscripts related to this field to be submitted. We will take care for a quick and thorough review process and are looking forward to receiving your submissions.

This Special Issue is supervised by PD Dr. Kevin Willy and PD Dr. Philipp Maximilian Doldi and assisted by Dr. Florian Doldi and Dr. Julian Wolfes (University Hospital of Münster, Munster, Germany).

Dr. Kevin Willy
Dr. Maximilian Doldi Philipp
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • cardiovascular remodeling
  • cardiac imaging
  • cardiovascular intervention
  • cardiovascular pathways
  • cardiovascular research
  • structural heart disease
  • cellular signaling

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Published Papers (1 paper)

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Review

16 pages, 533 KiB  
Review
Right Ventricular Dynamics in Tricuspid Regurgitation: Insights into Reverse Remodeling and Outcome Prediction Post Transcatheter Valve Intervention
by Philipp M. Doldi, Manuela Thienel and Kevin Willy
Int. J. Mol. Sci. 2025, 26(13), 6322; https://doi.org/10.3390/ijms26136322 - 30 Jun 2025
Viewed by 484
Abstract
Tricuspid regurgitation (TR) represents a significant, often silently progressing, valvular heart disease with historically suboptimal management due to perceived high surgical risks. Transcatheter tricuspid valve interventions (TTVI) offer a promising, less invasive therapeutic avenue. Central to the success of TTVI is Right Ventricular [...] Read more.
Tricuspid regurgitation (TR) represents a significant, often silently progressing, valvular heart disease with historically suboptimal management due to perceived high surgical risks. Transcatheter tricuspid valve interventions (TTVI) offer a promising, less invasive therapeutic avenue. Central to the success of TTVI is Right Ventricular Reverse Remodelling (RVRR), defined as an improvement in RV structure and function, which strongly correlates with enhanced patient survival. The right ventricle (RV) undergoes complex multi-scale biomechanical maladaptations, progressing from adaptive concentric to maladaptive eccentric hypertrophy, coupled with increased stiffness and fibrosis. Molecular drivers of this pathology include early failure of antioxidant defenses, metabolic shifts towards glycolysis, and dysregulation of microRNAs. Accurate RV function assessment necessitates advanced imaging modalities like 3D echocardiography, Cardiac Magnetic Resonance Imaging (CMR), and Computed Tomography (CT), along with strain analysis. Following TTVI, RVRR typically manifests as a biphasic reduction in RV volume overload, improved myocardial strain, and enhanced RV-pulmonary arterial coupling. Emerging molecular biomarkers alongside advanced imaging-derived biomechanical markers like CT-based 3D-TAPSE and RV longitudinal strain, are proving valuable. Artificial intelligence (AI) and machine learning (ML) are transforming prognostication by integrating diverse clinical, laboratory, and multi-modal imaging data, enabling unprecedented precision in risk stratification and optimizing TTVI strategies. Full article
(This article belongs to the Special Issue Biomechanics of Cardiovascular Remodeling)
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