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New Advances in the Field of Thrombosis and Hemostasis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 1150

Special Issue Editor


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Guest Editor
First Chair of Internal Medicine and Thrombotic and Haemorrhagic Diseases Unit, Department of Medicine (DIMED), University of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
Interests: thrombosis; bleeding; platelet activation; new coagulation tests; rare diseases; new coagulation biomarkers; diagnosis; extracellular vesicles
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Special Issue Information

Dear Colleagues,

The IJMS (International Journal of Molecular Sciences) has organized a Special Issue on “New Advances in the Field of Thrombosis and Hemostasis”.

A Special Issue focuses on collecting and disseminating new knowledge related to the important thrombosis and bleeding disorders diseases.

Moving from thrombosis to bleeding disorders, this issue aims to collect, provide, and disseminate new information on thrombosis, hemostasis, and vascular biology that will lead to new approaches in the diagnosis, therapy, prognosis, and prevention of thrombosis and hemorrhagic diseases.

Particular aspects that will be considered are coagulation factors and platelet activation involved in thrombus formation and bleeding disorders.  An important aim of this issue is to collect news regarding the research of new biomarkers, such as the expression of some micro RNA, proteins, cytokines, or specific circulating extracellular vesicles, as well as new essays that can help predict and monitor the course and clinical outcome of the patient. The journal considers congenital and acquired diseases of both hemorrhagic and thromboembolic disorders, as well as their diagnosis, treatment, and prevention.

I would be happy if you could contribute to this Special Issue with a short communication, a research article, or a review.

Dr. Claudia Maria Radu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • bleeding
  • thrombosis
  • new diagnostic tests
  • rare diseases
  • platelet function
  • biomarkers
  • risk factors
  • thrombocytopenia
  • endothelial dysfunction
  • autoantibodies
  • extracellular vesicles
  • stem cells
  • gene therapy

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Published Papers (1 paper)

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Research

14 pages, 3114 KiB  
Article
The Dynamic Landscape of the Coagulome of Metastatic Malignant Melanoma
by Jean-Philippe Arnault, Kimberley Chemmama, Khedidja Ferroudj, Julien Demagny, Laurence Panicot-Dubois, Antoine Galmiche and Zuzana Saidak
Int. J. Mol. Sci. 2025, 26(4), 1435; https://doi.org/10.3390/ijms26041435 - 8 Feb 2025
Viewed by 752
Abstract
The local expression of coagulation-related genes defines the tumor coagulome. The tumor coagulome plays a pivotal role in cancer-associated thrombosis (CAT) and hemostatic complications, such as venous thromboembolism (VTE), which are frequent in patients with advanced/metastatic cancer. Genomic analyses of human tumors, such [...] Read more.
The local expression of coagulation-related genes defines the tumor coagulome. The tumor coagulome plays a pivotal role in cancer-associated thrombosis (CAT) and hemostatic complications, such as venous thromboembolism (VTE), which are frequent in patients with advanced/metastatic cancer. Genomic analyses of human tumors, such as skin cutaneous melanoma (SKCM), have unveiled the complexity of the metastatic trajectories. However, no study to date has focused on the metastatic coagulome along these trajectories. Using bulk-tumor and single-cell analyses of primary SKCM, metastastic samples and circulating tumor cells (CTCs), we explored the coagulome of SKCM along metastatic progression. We identified consistent changes in the coagulome of SKCM metastases compared to primary tumors and observed metastatic site specificity. Compared to other metastatic sites, lung metastases of SKCM had a specific coagulome with a higher expression of F3, encoding Tissue Factor. Single-cell analyses were used to chart the inter- and intra-tumor heterogeneity and characterize the metastatic coagulome of SKCM. We found that a subpopulation of CTCs from SKCM expressed high levels of platelet genes, suggesting the contribution of CTC–platelet interactions to the CTC coagulome. These findings highlight the dynamic properties of the metastatic coagulome and its link to cancer progression. Full article
(This article belongs to the Special Issue New Advances in the Field of Thrombosis and Hemostasis)
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