Molecular Metabolism in Human Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 20 March 2026 | Viewed by 1823
Special Issue Editor
Interests: genetic markers; sleep apnea; exosomes; single cell; snRNA-seq; metabolic dysfunction; animal models for sleep apnea
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Molecular metabolism is fundamental to human health, governing how cells generate energy, regulate hormones, and synthesize essential biomolecules. When functioning optimally, these processes support critical systems such as brain activity, immune response, and tissue maintenance. However, disruptions in metabolic pathways are closely linked to the development of major diseases, including obesity, type 2 diabetes, cardiovascular disease, and cancer. Insulin resistance, for example, impairs glucose uptake and leads to chronic inflammation and tissue damage. In cancer, cells reprogram metabolic activity—often relying on aerobic glycolysis (the Warburg effect)—to support rapid growth and survival.
Recent advances in molecular biology and metabolomics have transformed our ability to investigate these disruptions at a granular level. Researchers can now map how genetic, dietary, and environmental factors interact to alter metabolism, revealing targets for highly specific therapeutic interventions. This growing body of knowledge is shifting the medical model from treating symptoms to correcting metabolic dysfunction at its root. Strategies such as enzyme-modulating drugs, personalized nutrition, and metabolic profiling are emerging as powerful tools in precision medicine.
Understanding molecular metabolism is not only vital for combating disease—it also offers a foundation for promoting long-term health and longevity. As research deepens, metabolism is becoming a central focus in the future of medicine.
Prof. Dr. Abdelnaby Khalyfa
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
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Keywords
- molecular metabolism
- metabolic pathways
- insulin resistance
- Warburg effect
- chronic disease
- metabolomics
- precision medicine
- metabolic dysfunction
- cancer metabolism
- personalized nutrition
- enzyme-targeted therapy
- systems biology
- cellular energy
- metabolic health
- preventative healthcare
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