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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Sarcomas: From Molecular Signatures to Morphologic Patterns
edited by
submission deadline 25 Dec 2026 | 2 articles | Viewed by 2350 | Submission Open
Keywords: sarcomas; histopathology; molecular pathology; FISH; gene fusion in sarcomas
(This special issue belongs to the Section Molecular Oncology)
Exploring the Interplay Between Food Components and the Gut: From Mechanisms to Microbiome Interaction
edited by and Lorenzo Nissen
submission deadline 25 Dec 2026 | 1 articles | Viewed by 2332 | Submission Open
Keywords: intestinal cells; nutrients; in vitro digestion; nutrigenomics; nutrigenetics; gut microbiota
(This special issue belongs to the Section Molecular Microbiology)
Molecular Aspects of Tumor Radiotherapy
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 2299 | Submission Open
Keywords: radiotherapy resistance; tumor microenvironment; DNA damage response; metabolic reprogramming; combination therapies
(This special issue belongs to the Section Molecular Oncology)
New Advances in Reproductive Immunology and Pathology
edited by Silvia Giugliano
submission deadline 25 Dec 2026 | 1 articles | Viewed by 2287 | Submission Open
Keywords: maternal–fetal immune tolerance; reproductive immunopathology; cytokine signaling in pregnancy; immune-related infertility; metabolome-immune crosstalk; microbiome influence on fertility
(This special issue belongs to the Section Molecular Immunology)
Molecular Informatics and AI in Cancer Research
edited by and
submission deadline 25 Dec 2026 | 2 articles | Viewed by 2249 | Submission Open
Keywords: molecular informatics; artificial intelligence (AI); cancer research; personalized medicine; high-throughput data; biomarkers; clinical applications; longitudinal data
(This special issue belongs to the Section Molecular Informatics)
Mitochondrial Dysfunction and Oxidative Stress in Human Diseases submission deadline 25 Dec 2026 | 1 articles | Viewed by 2183 | Submission Open
Keywords: mitochondrial dysfunction; oxidative stress; reactive oxygen species
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Machine Learning in Disease Diagnosis and Treatment: 2nd Edition
edited by
submission deadline 25 Dec 2026 | 2 articles | Viewed by 2122 | Submission Open
Keywords: machine learning; diagnosis; treatment; algorithm; predictive; artificial intelligence
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Autoimmune Diseases: The Molecular Basis and New Therapies
edited by
submission deadline 25 Dec 2026 | 3 articles | Viewed by 2055 | Submission Open
Keywords: autoimmunity; molecular mechanisms; biologics; immunotherapy; precision medicine
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms and Therapies of Pancreatic Cancer: 3rd Edition submission deadline 25 Dec 2026 | 3 articles | Viewed by 2046 | Submission Open
Keywords: pancreatic cancer; metabolism; cellular plasticity; tumor microenvironment; target therapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Crosstalk in Stress-Induced Psychopathology
edited by Ilaria Demori and
submission deadline 25 Dec 2026 | 2 articles | Viewed by 1970 | Submission Open
Keywords: Depression; Anxiety; Post-traumatic stress disorder; Early life stress; Microbiota–gut–brain axis; Blood–brain barrier; Neurotransmission; Neuroinflammation; Eating disorders; Addiction; Psychoneuroendocrineimmunology; Allostasis
(This special issue belongs to the Section Molecular Neurobiology)
The Tumor Microenvironment in Hepatocellular Carcinoma: Mechanistic Insights and Future Therapeutic Approaches
edited by
submission deadline 25 Dec 2026 | 2 articles | Viewed by 1936 | Submission Open
Keywords: advance or metastatic hepatocellular carcinoma; liver disease; radiotherapy; transarterial chemoembolization (TACE) or SBRT; immune checkpoint inhibitors; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
Advances in Angiogenesis: From Molecular Insights to Therapeutic Strategies
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1928 | Submission Open
Keywords: angiogenesis; molecular signaling; endothelial cells; tumor microenvironment; pro-angiogenic factors; anti-angiogenic therapy; vascular remodeling; hypoxia; VEGF pathway; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Cancer Epigenetics for Precision Medicine submission deadline 25 Dec 2026 | 1 articles | Viewed by 1927 | Submission Open
Keywords: cancer epigenetics; DNA methylation; precision medicine; cancer biomarker; therapeutic target; epidrugs
(This special issue belongs to the Section Molecular Oncology)
Breast Cancer and Hormone Receptors: Molecular Insights submission deadline 25 Dec 2026 | 2 articles | Viewed by 1916 | Submission Open
Keywords: hormone receptor-positive breast cancer; estrogen receptor (ER); progesterone receptor (PR); endocrine therapy resistance; breast cancer genomics; molecular biomarkers; transcriptomic profiling; targeted therapies
(This special issue belongs to the Section Molecular Oncology)
Recent Advances in Gastrointestinal Tract Oncology: Pathology, Diagnostics and Therapy (Second Edition)
edited by
submission deadline 25 Dec 2026 | 2 articles | Viewed by 1894 | Submission Open
Keywords: gastrointestinal cancer; esophageal cancer; gastric (stomach) cancer; colorectal cancer; liver cancer; pancreatic cancer; gallbladder and biliary tract cancer; genetic alterations; molecular subtyping; tumor microenvironment; innovative therapies; targeted therapies; tumor biomarkers
(This special issue belongs to the Section Molecular Oncology)
Molecular Aspects of Cancer Stem Cell Biology and Their Therapeutic Implications submission deadline 25 Dec 2026 | 1 articles | Viewed by 1874 | Submission Open
Keywords: cancer stem cells; chemotherapy; radiotherapy; transcription factors; stemness properties; chemoresistance; radioresistance
(This special issue belongs to the Section Molecular Oncology)
Drug Treatment for Bacterial Infections: 2nd Edition
edited by Janusz Madaj
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1855 | Submission Open
Keywords: bacterial infection; antibiotic-resistant bacteria; new agents in the treatment of bacterial infections; optimization of the use of already registered drugs; single antibacterial agents; combined antibacterial agents; new drug forms
(This special issue belongs to the Section Molecular Pharmacology)
Stem Cells for Biomedical Applications
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1812 | Submission Open
Keywords: stem cells biology; stem cells differentiation; stem cell-based regenerative therapies; stem cells exosomes; personalized medicine; stem cell-based 3D models
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanism of Sympathetic Nerves in Cardiovascular Diseases and Cancer
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1803 | Submission Open
Keywords: sympathetic nerve activity; adrenergic receptors; renal denervation; heart disease; stroke; atherosclerosis; hypertension; diabetes; metabolic syndrome; cancer
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Plant Biotechnology: From Pathogen Diagnostics to Disease Management submission deadline 25 Dec 2026 | 1 articles | Viewed by 1786 | Submission Open
Keywords: plant pathogens; diagnostic; isothermal; biosensor; RNAi; CRISPRi; QTL mapping; GWAS; MAS or MABC
(This special issue belongs to the Section Molecular Plant Sciences)
Current Advances and Perspectives in Microbial Genetics and Genomics—2nd Edition
edited by and Lucila Saavedra
submission deadline 25 Dec 2026 | 2 articles | Viewed by 1763 | Submission Open
Keywords: microbial genetics; genomics and metagenomics; yeasts; gene regulation; microbe–host interactions; adaptation and resistance mechanisms; microbial metabolism
(This special issue belongs to the Section Molecular Microbiology)
Advanced Research on Antimicrobial Nanomaterials submission deadline 25 Dec 2026 | 2 articles | Viewed by 1753 | Submission Open
Keywords: antimicrobial nanomaterials; metal/metal-oxide nanoparticles; stimuli-responsive platforms; photothermal/photodynamic mechanisms; biofilm inhibition
(This special issue belongs to the Section Materials Science)
Molecular and Biochemical Advances in Kidney Diseases and Genetics
edited by
submission deadline 25 Dec 2026 | 2 articles | Viewed by 1748 | Submission Open
Keywords: pathophysiology; molecular mechanisms; biomarkers; in silico data analysis; image analysis; animal models
(This special issue belongs to the Section Molecular Genetics and Genomics)
Research Advances in Plant Interactions with Bacteria and Fungi: From Molecular to Ecological Perspectives
edited by
submission deadline 25 Dec 2026 | 3 articles | Viewed by 1744 | Submission Open
Keywords: plant-microbe interactions; plant-bacteria interactions; plant-fungi interactions; biocontrol; beneficial microbes; endophytes; microbiome; plant growth-promoting microbes; synthetic microbial communities
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights into Ophthalmic Diseases
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1731 | Submission Open
Keywords: environmental hazards; ophthalmic diseases; molecular mechanisms; risk factors; disease prevention; oxidative stress; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Omics Insights into Stress Responses and Adaptation in Fish
edited by
submission deadline 25 Dec 2026 | 2 articles | Viewed by 1672 | Submission Open
Keywords: fish stress adaptation; environmental stressors; omics integration; molecular mechanisms; functional genomics; epigenetic regulation; systems biology; stress resilience
(This special issue belongs to the Section Molecular Biology)
Molecular and Cellular Mechanisms of Myocardial Disease submission deadline 25 Dec 2026 | 2 articles | Viewed by 1661 | Submission Open
Keywords: cardiac muscle; calcium; sarcomere; troponin; desmossomal complex; hypertrophic cardiomyopathy; dilated cardiomyopathy; arrhythmogenic cardiomyopathy; mitochondria; calmodulin
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Toxicity of Animal Venoms and the Components: Molecular Mechanisms of Action
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1647 | Submission Open
Keywords: venom toxicity; biochemical activity; toxin biology; cellular targets; peptide; protein; structure–function relationships
(This special issue belongs to the Section Molecular Biology)
Molecular and Omics Approaches in Toxicology and Precision Pharmacology
edited by
submission deadline 25 Dec 2026 | 2 articles | Viewed by 1626 | Submission Open
Keywords: toxicology; precision pharmacology; omics technologies; proteomics; mode of action (MoA); mechanism of activity; biomarkers; prediction and modeling
(This special issue belongs to the Section Molecular Toxicology)
Molecular Mechanisms of Reproduction and Reproductive Diseases
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1509 | Submission Open
Keywords: reproduction; implantation; fertilization; gametogenesis; preimplantation genetic testing; in vitro fertilization; infertility; miscarriage; reproductive aging; endometriosis; premature ovarian failure; menopause; preeclampsia; preterm birth; placenta; testis; azoospermia
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Synthesis, Modification, and Functional Characterization of Advanced Biomaterials for Bone Tissue Engineering
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1401 | Submission Open
Keywords: material functionalization; bioactive materials; antimicrobial; antibiofilm; coatings; scaffolds; bone cements; metal nanoparticles; controlled release; biocompatibility
(This special issue belongs to the Section Materials Science)
Autophagy and Apoptosis in Mammal Cells
edited by Kaja Urbańska and Anna Litwiniuk
submission deadline 25 Dec 2026 | 2 articles | Viewed by 1386 | Submission Open
Keywords: autophagy; apoptosis; cellular homeostasis; intra- and intercellular crosstalk; autophagic cell death; programmed cell death
(This special issue belongs to the Section Molecular Biology)
Advances in Electrochemical Detection Research: A Molecular Insight
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1366 | Submission Open
Keywords: electrochemical sensors; phenolic compounds; theoretical study; experimental study; nanostructured electrodes
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Anti-Cancer Effects of Natural Products: 2nd Edition
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1365 | Submission Open
Keywords: cancer; natural products; herbal medicine; anticancer therapies; metastasis; recurrence; resistance mechanism; novel biomarker
(This special issue belongs to the Section Molecular Pharmacology)
Advancements in Antioxidant Molecules: From Discovery to Therapeutic Applications
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1335 | Submission Open
Keywords: antioxidants; natural products; small molecules; polyphenols; reactive oxygen species; drug discovery; oxidative stress; apoptosis; target validation
(This special issue belongs to the Section Molecular Pharmacology)
The Role of Vitamin B6 in Metabolism and Genome Stability
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1331 | Submission Open
Keywords: vitamin B6; PLP; DNA damage; metabolism
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Metabolism of Alzheimer’s Disease
edited by and Maria Letizia Trincavelli
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1329 | Submission Open
Keywords: Alzheimer’s disease; brain metabolism; insulin resistance; lipid metabolism; APOE ε4; metabolic targets; insulin-sensitizing drugs; lifestyle and metabolic interventions
(This special issue belongs to the Section Molecular Neurobiology)
Wired for Change: Neurotransmitter Plasticity and Circuit Dynamics in Health and Disease
edited by Alessandra Porcu
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1310 | Submission Open
Keywords: neurotransmitter; behavioral neuroscience; neuropsychiatric disorders; neurological disorders; neuroplasticity; neuronal circuit
(This special issue belongs to the Section Molecular Neurobiology)
Plant Extracts and Their Biological Activities: In Vitro and In Vivo
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1294 | Submission Open
Keywords: plant extracts; bioactive compounds; molecular mechanisms; in vitro and in vivo studies; biological activities
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advanced Research on Comparative Reproductive Physiology submission deadline 25 Dec 2026 | 1 articles | Viewed by 1255 | Submission Open
Keywords: andrology; sperm; oocyte; gamete interactions; reproductive morphology; reproductive endocrinology; omics; epigenetics; pregnancy; all animal species
(This special issue belongs to the Section Molecular Biology)
Characterization and Biological Function of Marine Biopolymers
edited by
submission deadline 25 Dec 2026 | 2 articles | Viewed by 1250 | Submission Open
Keywords: marine-based biopolymers; sustainable extractions; polymer characterization; biological functions; marine resources
(This special issue belongs to the Section Materials Science)
Identification of Predictive Molecular Markers for Cancer Progression, Response to Therapy, and Disease Outcome
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1237 | Submission Open
Keywords: predictive biomarkers; cancer progression; therapy response; molecular signatures; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Exploring the Functional Activity of Natural Products
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1228 | Submission Open
Keywords: natural products; natural drug discovery; bioactive compounds; biological activity; molecular mechanisms; anti-inflammatory activity; anticancer properties; therapeutic potential
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Microfluidic-Assisted Synthesis of Nanomaterials: Precise Control of Size, Surface Chemistry and Molecular Interactions submission deadline 25 Dec 2026 | Viewed by 1178 | Submission Open
Keywords: microfluidics; nanomaterials; nanocomposites; microreactors; controlled synthesis; surface chemistry; molecular interactions; flow simulation; physicochemical characterization; advanced applications
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Mechanisms and Treatment Strategies in Diabetic Kidney Disease submission deadline 25 Dec 2026 | 1 articles | Viewed by 1159 | Submission Open
Keywords: diabetic kidney disease; oxidative stress; autophagy; inflammation; fibrosis; cell therapy; SGLT2 inhibitors and GLP-1 agonists; mesenchymal stem cells; gene therapy; translational nephrology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Food Components in Human Health
edited by and Klaudia Gustaw
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1118 | Submission Open
Keywords: bioactive compounds; functional food; phytochemicals; bioactive peptides; health-promoting foods; food chemistry; polyphenols; natural products; human health; prebiotic compounds; bioavailability; nutraceuticals; bioaccessibility
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Regulatory Mechanisms of the Tumor Microenvironment in Human Diseases submission deadline 25 Dec 2026 | 1 articles | Viewed by 1089 | Submission Open
Keywords: tumor microenvironment; cytokines; exosomes; non-tumor cells; tumor-associated immune cells; cancer prognosis; cancer diagnosis; oncotherapy
(This special issue belongs to the Section Molecular Oncology)
Molecular and Clinical Advances in Ophthalmic Inflammation, Infection, and Degeneration
edited by Hyun Jin Shin
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1082 | Submission Open
Keywords: ophthalmic inflammation; ocular infection; ocular degeneration; molecular mechanisms; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Strategies in Tuberculosis Drug Discovery
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1045 | Submission Open
Keywords: anti-tuberculosis agents; MDR-TB; XDR-TB; drug repurposing; hybrid drugs; high-throughput screening; structure-based drug design; drug discovery
(This special issue belongs to the Section Molecular Pharmacology)
Exploring Recent Research on Natural Compounds: From Biosynthesis to Application
edited by
submission deadline 25 Dec 2026 | Viewed by 1042 | Submission Open
Keywords: proteins like antibodies and enzymes; small molecules; plant extracts; biosynthesis; nanodelivery; drug discovery
(This special issue belongs to the Section Biochemistry)
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