The Role of Vitamin B6 in Metabolism and Genome Stability
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 5
Special Issue Editor
Interests: genetics; chromosome structure and segregation; DNA repair; cell division
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Vitamin B6 is a group of chemically related vitamers, with pyridoxal 5'-phosphate (PLP) acting as the essential coenzyme for over 160 distinct biochemical reactions, ranging from the synthesis of neurotransmitters to the intricate regulation of amino acid, lipid, and carbohydrate metabolism. While its metabolic importance has been recognized for decades, contemporary research is uncovering a far more profound role for vitamin B6 in the maintenance of genome integrity.
This Special Issue seeks to explore the intersection of nutritional biochemistry and molecular genetics, specifically focusing on how PLP or PLP-dependent enzymes mitigate the risks of DNA damage and chromosomal aberrations. We are particularly interested in studies that investigate the relationship between B6 status and the management of oxidative stress and the regulation of one-carbon metabolism, which is vital for DNA methylation and nucleotide synthesis. By bringing together original research articles and comprehensive reviews, this Issue aims to provide an updated perspective on how vitamin B6 serves as both a metabolic modulator and a guardian of the genome also through its sophisticated involvement in gene-nutrient interactions.
We welcome submissions that utilize diverse experimental approaches, including molecular biology, clinical trials, and bioinformatic modeling, to clarify how maintaining optimal B6 levels can prevent the development of metabolic syndromes, neurodegenerative pathologies, and cancer. This collection intends to bridge the gap between basic nutrient research and therapeutic applications, offering a platform for breakthroughs that define the molecular requirements for long-term genomic health in an era of personalized nutrition.
Dr. Fiammetta Verni
Guest Editor
Manuscript Submission Information
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Keywords
- vitamin B6
- PLP
- DNA damage
- metabolism
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