Molecular Crosstalk in Stress-Induced Psychopathology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 18
Special Issue Editors
Interests: psychoneuroendocrineimmunology; psychopathology; stress; fibromyalgia; nutrition
2. Research and Clinical Center for Neuropsychiatry of Moscow Healthcare Department, 115419 Moscow, Russia
Interests: adaptation; Alzheimer animal models; apoptosis; behaviour; biomarkers; cellular models; cerebral ischemia; dementia; depression; epilepsy; excitotoxicity; free radicals; glia; glucocorticoid signalin
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Special Issue Information
Dear Colleagues,
Since the pioneering work of Hans Selye, the human stress response has been recognized as an adaptive mechanism essential for survival. Nonetheless, mounting evidence indicates that early-life adversity and chronic psychosocial stress represent significant risk factors for the onset of various mental disorders, including depression, anxiety, eating disorders, substance abuse and neurodegenerative diseases, e.g., Alzheimer’s and Parkinson’s disease. The framework of psychoneuroendocrineimmunology (PNEI) offers a comprehensive network-based model to interpret the intricate bidirectional communication among key biological systems. This includes interactions between hormones, neurotransmitters, cytokines, across the blood-brain barrier and microbiota-derived metabolites, all of which are modulated by stress and may contribute to psychopathological outcomes.
The primary objective of this Special Issue is to advance current understanding of the molecular mechanisms underlying these complex inter-system interactions in the pathogenesis of mental disorders and brain pathology. We welcome contributions focused on molecular-level investigations, including preclinical studies, clinical trials, intervention research, narrative, or systematic reviews, as well as theoretical mathematical models of interactions.
Dr. Ilaria Demori
Prof. Dr. Natalia V. Gulyaeva
Guest Editors
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Keywords
- Depression
- Anxiety
- Post-traumatic stress disorder
- Early life stress
- Microbiota–gut–brain axis
- Blood–brain barrier
- Neurotransmission
- Neuroinflammation
- Eating disorders
- Addiction
- Psychoneuroendocrineimmunology
- Allostasis
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