Molecular and Biochemical Advances in Kidney Diseases and Genetics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 435
Special Issue Editor
Special Issue Information
Dear Colleagues,
Over 850 million people suffer from kidney disorders (KDs), which are a serious and expanding public health concern. They also operate as a "disease amplifier" for diabetes, heart disease, and infections, and put a tremendous financial burden on society. Acute kidney injury (AKI) affects approximately 10–15% of hospitalized patients and occurs in more than 50% of those admitted to intensive care units. Despite its frequent occurrence in clinical settings, AKI remains poorly understood from a pathophysiological standpoint. Chronic kidney disease (CKD) is a progressive pathological condition characterized by a glomerular filtration rate (GFR) below 60 mL/min/1.73 m2 and/or at least one indicator of renal function impairment, lasting for at least three months. It is a serious condition, the prevalence and incidence of which have been growing at an extremely high rate in the last few decades. A complex interaction of biological mechanisms characterizes chronic kidney disease (CKD). The pathophysiology and consequences of chronic kidney disease are driven primarily by inflammation, elevated oxidative and metabolic stress, endothelial dysfunction, vascular calcification resulting from inadequate calcium and phosphate metabolism, and coagulation abnormalities.
Nevertheless, even with the increasing awareness of the causes of kidney diseases, we remain significantly distant from fully comprehending the various mechanisms that contribute to kidney disorders. The purpose of this Special Issue, "Molecular and Biochemical Advances in Kidney Diseases and Genetics," is to offer a venue for the presentation of research on pathophysiology, biochemistry, molecular biology, and any other topics on the disruption of molecular mechanisms in the development of kidney diseases. We welcome original research articles and review articles that summarize developments in this area.
Prof. Dr. Silvio R. De Luka
Guest Editor
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Keywords
- pathophysiology
- molecular mechanisms
- biomarkers
- in silico data analysis
- image analysis
- animal models
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