ijms-logo

Journal Browser

Journal Browser

Molecular and Cellular Mechanisms of Myocardial Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 25 December 2026 | Viewed by 1561

Editor


E-Mail Website
Guest Editor
Department of Biology, Illinois Institute of Technology, Chicago, IL, USA
Interests: cardiac muscle; calcium; troponin; desmossomal complex; hypertrophic cardiomyopathy; dilated cardiomyopathy; arrhythmogenic cardiomyopathy; sarcomere; mitochondria; calmodulin
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Myocardial diseases arise from alterations in complex interactions among sarcomeric proteins, ion-handling systems, cell–cell junctions, and organellar function. This Special Issue of IJMS, “Myocardial Disease: Molecular and Cellular Mechanisms,” aims to showcase advances in elucidating the involvement of these pathways in health and disease at the molecular, cellular, and organ level. We invite authors to submit original research and reviews that explore cardiac muscle biology; calcium handling; sarcomere regulation; troponin function; desmosomal complex integrity; and the molecular basis of hypertrophic, dilated, and arrhythmogenic cardiomyopathies. Studies on mitochondrial signaling, metabolic remodeling, and calmodulin-dependent pathways are also welcome. Given the molecular focus of this Special Issue, purely clinical or imaging-based studies without mechanistic exploration are not suitable. However, we welcome clinical investigations and model-based studies (cellular, tissue, or animal) that employ biomolecular, biochemical, genetic, or biophysical experiments to uncover the underlying mechanisms of myocardial disease. Through this integrated lens, the primary goal of this Special Issue is to bridge basic and translational research, in order to advance our understanding of myocardial disease and enable the development of targeted therapeutic strategies.

This Guest Editor of this Special Issue is Dr. Maicon Landim-Vieira, who is assisted by Dr. Aurelia Fernandes (Universidade Federal do Espírito Santo, Brazil).

Dr. Maicon Landim-Vieira
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac muscle
  • calcium
  • sarcomere
  • troponin
  • desmossomal complex
  • hypertrophic cardiomyopathy
  • dilated cardiomyopathy
  • arrhythmogenic cardiomyopathy
  • mitochondria
  • calmodulin

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

22 pages, 4138 KB  
Article
Gut–Heart Axis: Microbiome Involvement in Wild-Type Transthyretin Amyloidosis
by Itzel Ivonn López-Tenorio, Luis Alejandro Constantino-Jonapa, Samuel Jaimez-Alvarado, Fernando Hernández-Quiroz, Esteban Jorge-Galarza, Alma Reyna Escalona-Montaño, Amedeo Amedei, Rodrigo Soria-García, Enrique Alexander Berrios-Barcenas and María Magdalena Aguirre-García
Int. J. Mol. Sci. 2026, 27(9), 3763; https://doi.org/10.3390/ijms27093763 - 23 Apr 2026
Viewed by 593
Abstract
Cardiac amyloidosis is a rare and progressive condition characterized by the extracellular deposition of amyloid fibrils in multiple organs. Wild-type transthyretin amyloidosis (ATTR-wt) is the most common type affecting subjects above 60 years old. Recent and growing evidence suggests a potential link between [...] Read more.
Cardiac amyloidosis is a rare and progressive condition characterized by the extracellular deposition of amyloid fibrils in multiple organs. Wild-type transthyretin amyloidosis (ATTR-wt) is the most common type affecting subjects above 60 years old. Recent and growing evidence suggests a potential link between GM and cardiac amyloidosis. In this scenario, the aim of the present study is to characterize the gut microbiota (GM), related metabolites and inflammatory biomarkers in ATTR-wt patients. In the ATTR patients we identified Prevotella_9 as the core OTUs (Operational Taxonomic Unit) of this group, alongside Prevotella 7, Prevotellaceae_UCG-003 and Prevotellaceae_NK3B31. In addition, there were increased levels of long fatty acids, including tetradecanoic, hexadecanoic and octadecanoic acids, in the ATTR group. The data obtained suggest that ATTR patients have an altered gut microbiota that could be used as a potential biomarker in metabolic and cardiovascular diseases, as well as a potential predictor of adverse prognosis in ATTR patients. In addition, the intestinal dysbiosis in ATTR patients could be associated with low-grade endotoxemia promoting a pro-inflammatory state due to the translocation of bacterial components, such as LPS (lipopolysaccharide), into blood circulation. Full article
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Myocardial Disease)
Show Figures

Graphical abstract

Review

Jump to: Research

24 pages, 1283 KB  
Review
Beyond Reperfusion: Early Molecular Drivers and Therapeutic Opportunities in Acute Post-Infarction Cardiac Fibrosis
by Desaree Tan, Yi Ee Lye, Pranjal Patel, Nay Aung Minn, Anne Cao Le, Alex Bobik and Tin Kyaw
Int. J. Mol. Sci. 2026, 27(10), 4409; https://doi.org/10.3390/ijms27104409 - 15 May 2026
Viewed by 594
Abstract
Heart failure is a leading cause of global morbidity and mortality, often developing as a consequence of acute myocardial infarction. Current management focuses on timely reperfusion via percutaneous coronary intervention. Yet, this approach fails to prevent the molecular cascades that drive the death [...] Read more.
Heart failure is a leading cause of global morbidity and mortality, often developing as a consequence of acute myocardial infarction. Current management focuses on timely reperfusion via percutaneous coronary intervention. Yet, this approach fails to prevent the molecular cascades that drive the death of viable yet stressed cardiomyocytes within the infarct and peri-infarct zone. Effective antifibrotic therapies remain limited, highlighting a critical gap in current management strategies. This review aims to integrate current understanding of the molecular mechanisms underpinning post-infarct fibrosis and potential interventions for therapeutic development. This emphasis on molecular death signal activation and cell elimination highlights the redundancy of interconnecting fibrosis pathways. Anti-inflammatory and cell-targeted therapies focussing on oxidative stress and haemodynamic load have demonstrated strong preclinical promise. Yet, these approaches have largely failed to translate into clinical benefit. Overall, these limitations emphasise a narrow therapeutic window for intervention. As such, current therapies often fail to preserve metabolically vulnerable myocardium that remains potentially salvageable. Therefore, emerging approaches including RNA-based therapies, cardiac reprogramming, and targeted delivery systems offer new opportunities to improve therapeutic precision. Collectively, these findings support a shift toward early, cell-targeted intervention strategies. This approach aims to prevent progression to heart failure and increases patient quality of life. Full article
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Myocardial Disease)
Show Figures

Figure 1

Back to TopTop