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Exploring the Interplay Between Food Components and the Gut: From Mechanisms to Microbiome Interaction

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 30 May 2026 | Viewed by 12

Special Issue Editors


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Guest Editor
Department of Food, Environmental and Nutritional Sciences (Defens), University of Milan, Via Celoria 2, 20133 Milan, Italy
Interests: cultured cells; in vitro digestion; bioactivity
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department for the Promotion of Human Science and Quality of Life, San Raffaele University of Rome, 00166 Rome, Italy
Interests: in vitro intestinal model; food microbiology; host-microbe interaction; bifidobacteria
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The dynamic interplay between food and the intestine is bidirectional: food provides energy and molecular signals, while the intestine—together its vast and diverse microbiota—mediates digestion, nutrient absorption, and communication with the rest of the body. Dietary components can directly influence host physiology and act as health-promoting agents. At the same time, they shape the composition and function of the gut microbiota, which ferments food components and produces beneficial metabolites that affect overall health and disease risk.

The objective of this Special Issue is to bring together studies investigating the effects of food components on the gut, long with the molecular mechanisms underlying these effects, at both the enterocyte and microbiome levels. To achieve this goal, we welcome and encourage submissions of research articles and reviews from in silico, in vitro, and clinical studies.

We look forward to receiving your contributions.

Dr. Mattia Di Nunzio
Dr. Lorenzo Nissen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • intestinal cells
  • nutrients
  • in vitro digestion
  • nutrigenomics
  • nutrigenetics
  • gut microbiota

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Published Papers

This special issue is now open for submission.
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