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Advances in Electrochemical Detection Research: A Molecular Insight

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Physical Chemistry and Chemical Physics".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 642

Special Issue Editor


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Guest Editor
Grupo de Electroanalítica (GEANA), Departamento de Química, Instituto para el Desarrollo Agroindustrial y de la Salud (IDAS), Facultad de Ciencias Exactas, Fisicoquímicas y Naturales, Universidad Nacional de Río Cuarto, Agencia Postal N° 3, Río Cuarto X5804BYA, Argentina
Interests: electrochemistry; sensors; microelectrodes; chemometrics; electrochemical reaction mechanisms

Special Issue Information

Dear Colleagues,

The development of electrochemical detection sensors is a field of great interest in modern analytical chemistry, especially those sensors modified with nanomaterials (such as graphene and its derivatives, MWCNT, etc.). Furthermore, the use of these platforms in the determination of phenolic compounds is highly relevant.

This special edition aims to present recent advances in the theoretical and computational study of the electrochemical oxidation mechanism of phenols (at the molecular level) on bare electrodes or electrodes modified with nanostructures, with potential applications in the development of electrochemical sensors.

We will be focusing on theoretical and experimental studies of the electrooxidation mechanisms of phenolic compounds (both synthetic and natural, like flavonoids and oxygenated terpenes), looking at them from a molecular perspective, and exploring their potential application as electrochemical sensing platforms.

This Special Issue is supervised by Dr. Gastón Darío Pierini and assisted by Dr. Edgardo Maximiliano Gavilán-Arriazu, maxigavilan@gmail.com (National University of Santiago del Estero (UNSE), Santiago del Estero G4206XCP, Argentina).

Dr. Gastón Pierini
Guest Editor

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Keywords

  • electrochemical sensors
  • phenolic compounds
  • theoretical study
  • experimental study
  • nanostructured electrodes

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Published Papers (1 paper)

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Research

18 pages, 2320 KB  
Article
Understanding the Oxidation Electrochemistry of Adsorbed Eugenol on a Glassy Carbon Electrode Modified with Electrochemically Partially Reduced Graphene Oxide: A Theoretical and Experimental Approach
by Gastón Darío Pierini, Edgardo Maximiliano Gavilán-Arriazu, Sergio Antonio Rodriguez, Sebastián Noel Robledo, Héctor Fernández and Adrian Marcelo Granero
Int. J. Mol. Sci. 2026, 27(5), 2461; https://doi.org/10.3390/ijms27052461 - 7 Mar 2026
Viewed by 358
Abstract
The electro-oxidation of eugenol (EUG) natural antioxidant was studied by cyclic voltammetry in phosphate buffer solutions (PBS) of different pH at electrochemically partially reduced graphene oxide (GCE/ePRGO). The voltammetric responses were mainly controlled by adsorption at this modified electrode. Current values were higher [...] Read more.
The electro-oxidation of eugenol (EUG) natural antioxidant was studied by cyclic voltammetry in phosphate buffer solutions (PBS) of different pH at electrochemically partially reduced graphene oxide (GCE/ePRGO). The voltammetric responses were mainly controlled by adsorption at this modified electrode. Current values were higher at pH 2.0 PBS, therefore, this pH was chosen to perform all experiments. DFT calculations of pKa’s and standard potentials defined the possible pathways of eugenol and its oxidation products. These pathways were evaluated through the comparison of voltammetric simulations of adsorbed species with experiments at pH 2.0, which also allowed for the estimation of the values of the kinetic parameters involved in electrochemistry. Our findings suggest a multi-step redox process in which Eugenol is first oxidized to the radical species and then to a cationic product. At this stage, the pathways branch into to methylenquinone and a 4-allyl-1,2-diquinone molecules. 4-allyl-1,2-diquinone is finally reduced in single or double reversible electrochemical step to the hydroquinone species. The present physicochemical work allows for a deeper understanding of the eugenol oxidation mechanism, which was only partially proposed in previous studies. Full article
(This article belongs to the Special Issue Advances in Electrochemical Detection Research: A Molecular Insight)
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