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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Understanding of Allergen Exposome

edited by

Fernando Pineda

and

Ruperto Gonzalez-Perez

submission deadline 20 Apr 2026 | 4 articles | Viewed by 5951 | Submission Open

Keywords: allergen exposome; profile allergen exposures; climatic change; airborne allergens; molecular triggers; microbial allergens

(This special issue belongs to the Section Molecular Immunology)

Molecules and Mechanisms of Oxidative Stress Relevant in the Pathophysiology of Diseases

edited by

Cinzia Signorini

submission deadline 20 Apr 2026 | 4 articles | Viewed by 5903 | Submission Open

Keywords: redox-active iron; reactive oxygen species; antioxidants; oxidative damage; biomarkers; degenerative disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Stem Cells in Health and Disease: 3rd Edition

edited by

Maja Ludvigsen

submission deadline 20 Apr 2026 | 4 articles | Viewed by 5757 | Submission Open

Keywords: stem cell regulation; differentiation; pluripotency; reprogramming; stem cell therapy; cancer stem cell/tumor-initiating cell; therapy resistance; regenerative medicine; metabolic plasticity

(This special issue belongs to the Section Molecular Biology)

Natural Medicines and Functional Foods for Human Health

edited by Qiong Wang

submission deadline 20 Apr 2026 | 2 articles | Viewed by 5589 | Submission Open

Keywords: functional food; natural medicine; traditional Chinese medicine; memory; depression; dementia; Alzheimer’ s disease; Parkinson’ s disease; space medicine; sleeplessness; anti-inflammation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Genetic, Epigenetic and Microbiota Molecular Insights for Crop Resilience to Abiotic Stress

edited by

Aliki Kapazoglou

submission deadline 20 Apr 2026 | 2 articles | Viewed by 5499 | Submission Open

Keywords: abiotic stress; tolerance; crop resilience; crop sustainability; environmental conditions; climate change; gene regulation; epigenetic mechanisms; microbiota communities; microbiome

(This special issue belongs to the Section Molecular Plant Sciences)

Musculoskeletal Diseases: Advances in Molecular Mechanisms and Therapeutic Approaches

edited by

Jung Eun Kim

submission deadline 20 Apr 2026 | 3 articles | Viewed by 5157 | Submission Open

Keywords: bone; muscle; tendon; cartilage; osteoporosis; sarcopenia; tendinopathy; osteoarthritis; musculoskeletal pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Products for Neuroprotection and Neurodegeneration

edited by

Patrycja Kupnicka

submission deadline 20 Apr 2026 | 4 articles | Viewed by 5148 | Submission Open

Keywords: natural products; bioactive compounds; neuroprotection; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Novel Approaches for Tissue Repair and Tissue Regeneration

edited by Srinivas Madduri

submission deadline 20 Apr 2026 | 2 articles | Viewed by 5117 | Submission Open

Keywords: injuries; tissue repair; tissue regeneration; tissue engineering; tissue bioengineering; bioactive biomaterial; cell and gene therapeutics; hydrogel; immune modulation

(This special issue belongs to the Section Molecular Biology)

Germline Stem Cells: New Insights

edited by

Thomas Skutella

submission deadline 20 Apr 2026 | 1 articles | Viewed by 5111 | Submission Open

Keywords: signaling pathway; spermatogonia development; oocyte development; microarray analysis; single-cell sequencing; epigenetic mechanisms; germline stem cell

(This special issue belongs to the Section Molecular Biology)

Tea and Health

edited by

Mingzhe Yao

and

Kang Wei

submission deadline 20 Apr 2026 | 3 articles | Viewed by 5000 | Submission Open

Keywords: tea plant (Camellia sinensis); molecular mechanism; human health; nutrients; quality-related component; genes identification

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Plant Genomics and Genetics: 3rd Edition

edited by

Hengling Wei

submission deadline 20 Apr 2026 | 6 articles | Viewed by 4940 | Submission Open

Keywords: plant genomics; plant genetics; abiotic stresses; salt resistance; genome; next-generation sequencing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Plant Breeding and Genetics: New Findings and Perspectives

edited by

Andrés J. Cortés

submission deadline 20 Apr 2026 | 7 articles | Viewed by 4934 | Submission Open

Keywords: quantitative genetics; classical plant breeding; marker-assisted selection; genomic selection; speed breeding; gene editing and biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

The Blood–Brain Barrier and Neuroprotection

edited by Aruna Sharma and Hari Shanker Sharma

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4881 | Submission Open

Keywords: blood– brain barrier; neurodegenerative diseases; nanoformulations; drug development; delivery systems

(This special issue belongs to the Section Molecular Neurobiology)

Type 1 Diabetes: Molecular Mechanisms and Therapeutic Approach

edited by Preeti Chhabra

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4878 | Submission Open

Keywords: type 1 diabetes; microbiome; proteomics; immunotherapy; β -cell replacement; single-cell sequencing; stem cells; gene editing technologies; tolerance

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Micro-Nano Materials for Drug Delivery and Disease Treatment

edited by

Maoquan Chu

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4856 | Submission Open

Keywords: biomaterials; nanoparticle-loaded bacterial cells; nanoparticle-loaded cells; bioimaging and diagnosis; therapy

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Genetics, Breeding, and Multi-Omics Approaches in Rice Research

edited by

Zakaria Prodhan

submission deadline 20 Apr 2026 | 4 articles | Viewed by 4844 | Submission Open

Keywords: rice genetics and breeding; molecular breeding of rice; rice genomics and proteomics; genes related to abiotic stress tolerance in rice; molecular biology and multi-omics in rice research

(This special issue belongs to the Section Molecular Plant Sciences)

Natural Active Substances in Human Diseases

edited by

Hyeung-Jin Jang

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4844 | Submission Open

Keywords: natural active substances; bioactive compounds; molecular mechanisms; traditional medicine; metabolic disorders; inflammatory diseases; neurodegenerative diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Perspectives in Nanomedicine

edited by

Stefano Leporatti

submission deadline 20 Apr 2026 | 1 articles | Viewed by 4776 | Submission Open

Keywords: nanomedicine; drug delivery; nano therapy and diagnostics; micro and nanofluidic tools; hybrid nanoparticles; CAR-T nanotechnologies

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Targets and Immunotherapy for Autoimmune Diseases

edited by

Neetu Srivastava

submission deadline 20 Apr 2026 | 1 articles | Viewed by 4766 | Submission Open

Keywords: autoimmunity; autoimmune diseases; immunotherapy; signaling pathway; molecular targets; antibody; T cells; B cells

(This special issue belongs to the Section Molecular Immunology)

Molecular Microbiology in the Omics Era: Genomics, Metagenomics and Computational Insights

edited by

Fei Liu

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4634 | Submission Open

Keywords: microbial genomics; metagenomics; computational biology; antimicrobial resistance; host– microbe interactions; multi-omics integration; bioinformatics tools; machine learning in microbiology

(This special issue belongs to the Section Molecular Microbiology)

Isolation and Biological Activities of Natural Products: Focus on Molecular Advance

edited by Pedro Ferreira and

Patricia Reboredo-Rodríguez

submission deadline 20 Apr 2026 | 4 articles | Viewed by 4538 | Submission Open

Keywords: natural products; sustainable isolation; biological activities; therapeutic potential; structure-activity relationships; omics technologies; bioavailability; functional foods; green chemistry; molecular docking

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Techniques and Strategies in Drug Design and Discovery, 3rd Edition

edited by

George Mihai Nitulescu

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4479 | Submission Open

Keywords: drug discovery; drug development; target identification; computational drug design; structure-based drug design; ligand-based drug design

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in Polymeric Biomaterials

edited by

Diego Acevedo

submission deadline 20 Apr 2026 | 1 articles | Viewed by 4461 | Submission Open

Keywords: biopolymers; biocomposites; nanomaterials; applications

(This special issue belongs to the Section Materials Science)

Characterization and Biological Function of Plant Extracts

edited by

Simonetta Cristina Di Simone

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4450 | Submission Open

Keywords: plant extracts; phytochemical characterization; bioactive compounds; biological activity; molecular mechanisms; gene expression; pharmacognosy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Inflammatory Bowel Disease: Focus on Molecular Research

edited by David Meriwether and

Hon Wai Koon

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4420 | Submission Open

Keywords: inflammatory bowel disease; gut microbiota; genomic sequencing; proteomic; lipidomic; metabolomic; therapy; biomarker; animal and organoid model

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Quadruplex DNA and Its Ligands for Disease Treatment

edited by

Ding Li

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4407 | Submission Open

Keywords: quadruplex; i-motif; transcriptional regulation; apoptosis; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

False-Positive and False-Negative Laboratory Biomarkers

edited by Michela Salvatici and Lorenzo Drago

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4392 | Submission Open

Keywords: biomarkers; false positives/negatives; protein biomarkers; nucleic acid markers; multi-omics; single-cell sequencing; liquid biopsy

(This special issue belongs to the Section Biochemistry)

Molecular and Cellular Research on the Glioma and Tumor Microenvironment

edited by

Maria Beatrice Morelli

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4297 | Submission Open

Keywords: tumour microenvironment; immune cells; cell siganling; tumor niche; tumor heterogeneity; TMZ resistance; new therapeutic strategies; endothelial cells; fibroblasts; extracellular matrix

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

MicroRNAs and Other Non-Coding RNAs as Regulators, Biomarkers, and Therapeutic Targets, 2nd Edition

edited by

Wan Lee

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4287 | Submission Open

Keywords: non-coding RNAs; microRNA; lncRNA; circRNA; piRNA; biomarker; therapeutic target

(This special issue belongs to the Section Molecular Biology)

The Roles of Phytochemicals and Antioxidants in Colon Cancers

edited by

Nunzio Antonio Cacciola

Francesca Borrelli

and

Paola De Cicco

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4214 | Submission Open

Keywords: colon cancer; colorectal cancer; natural products; drug-resistant; phytochemicals; antioxidants; cellular and molecular mechanisms; anti-cancer activity; prevention; treatments

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights and Treatments for Gynecological Cancers

edited by

Nicoletta D'Alessandris

submission deadline 20 Apr 2026 | 1 articles | Viewed by 4202 | Submission Open

Keywords: gynecological cancers; cancers; endometrial cancers; cervical cancer; tumor microenvironment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antioxidants: The Molecular Guardians Against Oxidative Stress

edited by

Karolina A. Wojtunik-Kulesza

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4177 | Submission Open

Keywords: antioxidant; free radical; oxidative stress; essential oils; secondary plant metabolites

(This special issue belongs to the Section Biochemistry)

Biological and Molecular Aspects of Exercise Adaptation

edited by

Alessandra Modesti

submission deadline 20 Apr 2026 | 4 articles | Viewed by 4114 | Submission Open

Keywords: exercise; redox homeostasis; metabolic state; biological; physiological

(This special issue belongs to the Section Molecular Biology)

Advancing Regenerative Medicine: Basic Research and Translation in Clinics

edited by

Dragan Primorac

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4017 | Submission Open

Keywords: regenerative medicine; stem cells; tissue engineering; exosomes; orthobiologics

(This special issue belongs to the Section Molecular Biology)

Amyotrophic Lateral Sclerosis Behind Motor Neurons

edited by

Patrizia Longone

and Ezia Guatteo

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3980 | Submission Open

Keywords: non-neuronal cells; neurotransmitters; systemic disease; motor system; neuronal circuitry; skeletal muscle metabolism; muscle oxidative metabolism

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease

edited by Rifaat Safadi and Johnny Amer

submission deadline 20 Apr 2026 | 3 articles | Viewed by 3971 | Submission Open

Keywords: MASLD (metabolic dysfunction-associated steatotic liver disease); lipotoxicity; inflammation; mitochondrial dysfunction; gut– liver axis; liver– spleen axis; fibrosis biomarkers; translational hepatology; precision liver medicine; insulin resistance; molecular therapeutics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Novel Insights into Bone Tissue: Pathologies and Therapeutic Strategies

edited by

Francesca Salamanna

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3969 | Submission Open

Keywords: bone tissue; pathologies; regenerative medicine; biomechanics; diagnostics; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Anxiety and Depression: Pathomechanisms and Therapeutic Strategies

edited by

Magdalena Sowa-Kućma

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3942 | Submission Open

Keywords: anxiety; depression; anxiolytics; antidepressants; animal models

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Lung Inflammation, Injury, and Repair (Second Edition)

edited by

Andreas Schwingshackl

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3897 | Submission Open

Keywords: lung; inflammation; injury; repair; fibrosis; diagnostics; therapeutics; acute respiratory distress syndrome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Therapies, Pathogenetic and Inflammatory Mechanisms in Thrombosis

edited by

Matteo Becatti

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3872 | Submission Open

Keywords: thromboinflammation; endothelial dysfunction; antithrombotic therapies; oxidative stress; thrombosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Mutations and Polymorphisms in Various Diseases: 2nd Edition

edited by

Anna Cieślińska

submission deadline 20 Apr 2026 | 4 articles | Viewed by 3843 | Submission Open

Keywords: nutrigenomics; polymorphism; SNPs; mutations; predisposition; correlation; diversity; deletion; insertion

(This special issue belongs to the Section Molecular Genetics and Genomics)

Chitosan Materials: Recent Advances in Modification, Properties and Application

edited by

Gabriela Dudek

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3821 | Submission Open

Keywords: chitosan materials; biomedical applications; agriculture and food industry; water treatment and environmental applications; nanotechnology and advanced materials

(This special issue belongs to the Section Macromolecules)

Advances in Molecular and Physiological Responses of Insects to Biotic, Abiotic and Xenobiotic Constraints

edited by

Farman Ullah

Shuo Yan

and Yaobin Lu

submission deadline 20 Apr 2026 | 3 articles | Viewed by 3820 | Submission Open

Keywords: climatic changes; chemical insecticides; insect adaptation mechanisms; resistance mechanisms; ecosystem services; insect ecology; thermal stress adaptations

(This special issue belongs to the Section Molecular Biology)

Amyotrophic Lateral Sclerosis: From Molecular Basis to Therapies

edited by

Matteo Bordoni

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3725 | Submission Open

Keywords: ALS; pathomechanisms; genetics; epigenetics; disease models; neuroinflammation; mithocondria; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights in Biomarkers of Autoimmune and Autoinflammatory Diseases: 2nd Edition

edited by

Mariapaola Marino

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3714 | Submission Open

Keywords: inflammaging; inflammasome; autoantibodies; free light chains; cytokines; receptor; signal transduction; innate immunity; adaptive immunity

(This special issue belongs to the Section Molecular Immunology)

Latest Review Papers in Molecular Immunology, 3rd Edition

edited by

Manlio Ferrarini

and

Vincenzo Barnaba

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3709 | Submission Open

Keywords: molecular immunology; review; immune cells

(This special issue belongs to the Section Molecular Immunology)

New Insights in the Mechanism of Obstetrical Complications: Prevention, Diagnosis, Monitoring, Treatment

edited by

Lucia Maria Procopciuc

and

Roxana Liana Lucaciu

submission deadline 20 Apr 2026 | 3 articles | Viewed by 3683 | Submission Open

Keywords: high blood pressure; gestational diabetes; infections; preeclampsia; eclampsia; preterm labor; depresion; anxiety; pregnancy loss/miscarriage; stillbirth; premature membrane rupture; vaginal bleeding; placenta previa; anemia; intrauterine growth restriction; maternal risk factors; fetal risk factors; endothelial dysfunction; angiogenesis; oxidative stress; hormonal modifications; dyslipidemia; biochemical; genetic; epigenetic determinations; computational analysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antitumor Activity of Natural Products

edited by

Spiro Mihaylov Konstantinov

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3659 | Submission Open

Keywords: natural compounds and extracts with antitumor activity; studies on molecular mechanisms; signal transduction modulation in tumor cells; immunomodulating activity; mitosis inhibition; cell differentiation; cell death induction (apoptosis/autophagy)

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Neurogenesis and Neurodegeneration: Insights into Regeneration and the Impact of Neurotrophins

edited by

Eva Terzibasi Tozzini

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3561 | Submission Open

Keywords: neurogenesis; neurodegeneration and regeneration; neurotrophins; brain plasticity

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Long Non-Coding RNAs in Stress and Diseases

edited by

Antonis Giannakakis

and

Vladimir A. Kuznetsov

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3550 | Submission Open

Keywords: long non-coding RNAs (lncRNAs); human health; core stress response; genotoxic stress; exosomes; biomarkers; stress-related diseases; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 2701-2750 on page 55 of 69.

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