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Novel Approaches for Tissue Repair and Tissue Regeneration

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 August 2025 | Viewed by 477

Special Issue Editor


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Guest Editor
Bioengineering and Neuroregeneration Laboratory, Department of Surgery, University of Geneva, 1211 Geneva, Switzerland
Interests: injuries; tissue repair; tissue regeneration; tissue engineering; tissue bioengineering; bioactive biomaterial; cell and gene therapeutics; hydrogel; immune modulation

Special Issue Information

Dear Colleagues,

Tissue repair and regeneration represent both critical and complex challenges in modern medicine. As the field continues to advance, there is a growing body of evidence supporting the potential of biomaterials and stem cells in facilitating tissue reconstruction and promoting regenerative processes. However, despite these promising developments, existing therapeutic strategies remain suboptimal, often falling short in fully addressing the intricate needs of tissue repair. To overcome these limitations, there is an urgent need for novel and innovative approaches that focus on enhancing the structural, biochemical, and mechanical properties of biomaterial scaffolds. These improvements are essential to better support the complex requirements of tissue growth, functional restoration, and integration within the body. Given these considerations, the current Special Issue seeks to invite research articles that explore emerging trends, cutting-edge methodologies, and new insights in the field of tissue engineering and regenerative medicine. 

Key topics of interest for this Special Issue include, but are not limited to, the following:

  • Engineered Biomaterials: Development of advanced biomaterials with tailored properties to mimic the native extracellular matrix and promote optimal tissue regeneration. 
  • Bioengineered Cells and Tissues: Innovative strategies for the engineering of cells and tissues, including the use of stem cells, growth factors, and genetic modifications to enhance tissue functionality. 
  • Slow and Local Delivery of Bioactive Molecules: Approaches that utilize controlled release systems to deliver bioactive molecules (such as growth factors, cytokines, and small molecules) in a spatially and temporally regulated manner to promote tissue repair and regeneration. 
  • 3D Bioprinting Approaches for Functionalized Tissue Constructs: The use of 3D bioprinting technologies to create complex, functional tissue constructs that closely replicate native tissue architecture and functionality. 
  • Interdisciplinary Pre-Clinical and Clinical Research for Nervous System Regeneration: Collaborative efforts between fields such as neurobiology, materials science, and bioengineering to advance therapeutic strategies for regenerating both the peripheral and central nervous systems. 

This Special Issue aims to provide a platform for cutting-edge research that will pave the way for more effective therapies in tissue engineering and regenerative medicine. We encourage contributions that propose novel methodologies, highlight current challenges, and offer potential solutions that could transform clinical applications in regenerative healthcare.

Dr. Srinivas Madduri
Guest Editor

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Keywords

  • injuries
  • tissue repair
  • tissue regeneration
  • tissue engineering
  • tissue bioengineering
  • bioactive biomaterial
  • cell and gene therapeutics
  • hydrogel
  • immune modulation

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Published Papers (1 paper)

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Review

33 pages, 8701 KiB  
Review
Clinical Safety and Efficacy of Allogeneic Adipose Stem Cells: A Systematic Review of the Clinical Trials
by Alexandre Asch, Daniel F. Kalbermatten and Srinivas Madduri
Int. J. Mol. Sci. 2025, 26(13), 6376; https://doi.org/10.3390/ijms26136376 - 2 Jul 2025
Viewed by 323
Abstract
Allogeneic adipose stem cells (AASCs) are increasingly recognized for their potential in regenerative medicine. They offer a promising alternative to autologous cells, with potential advantages such as availability and reduced morbidity in the recipient. Therefore, the aim of the present systematic review was [...] Read more.
Allogeneic adipose stem cells (AASCs) are increasingly recognized for their potential in regenerative medicine. They offer a promising alternative to autologous cells, with potential advantages such as availability and reduced morbidity in the recipient. Therefore, the aim of the present systematic review was to explore AASCs applications in various diseases and conditions, including skin lesions, Crohn’s disease, glandular dysfunction, kidney disease, spinal muscular atrophy and osteoarthritis. This review was conducted according to PRISMA guidelines; PubMed, Embase and Web of Science databases were used to search for studies published between 2011 and 2024, without language restrictions. Our review was strictly limited to the inclusion of controlled clinical trials to ensure the relevance and quality of the data. After screening, 22 articles were retained, with a total of 953 patients that met the established inclusion criteria. The data obtained from these studies showed that AASCs have promising efficacy in improving scars and ulcers, managing Crohn’s disease, and treating glandular dysfunction and kidney disease. In spinal muscular atrophy and osteoarthritis, preliminary results also suggested potential benefits. AASCs-based treatments were well tolerated with no major adverse effects, thus emphasizing their favorable safety profile. AASCs show a significant potential for a variety of clinical applications, but the results must be interpreted with caution due to the methodological limitations of the included studies. Well-designed Phase III clinical trials are needed to confirm these promising results and ensure the safe and effective use of AASCs in clinical practice. This review highlights the importance of the standardization of procedures and raises relevant ethical issues related to the use of donor cells. Full article
(This article belongs to the Special Issue Novel Approaches for Tissue Repair and Tissue Regeneration)
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