Stem Cells in Health and Disease: 3rd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 1613
Special Issue Editor
2. Department of Clinical Medicine, Aarhus University, 8200 Aarhus N, Denmark
Interests: stem cells; leukemia; lymphoma; sarcoma; gene therapy; proteomics; imaging flow cytometry
Special Issue Information
Dear Colleagues,
In recent years, our knowledge about the dual role of stem cells in health and disease has increased significantly. However, the biological and molecular mechanisms of this double function are yet to be fully understood.
New advancements in stem-cell research open a new door for patients suffering from diseases not yet successfully treated. Stem-cell-based therapy, including embryonic stem cells, human pluripotent stem cells, multipotent mesenchymal stem cells, and neural stem cells, has recently emerged as a key player in regenerative medicine because of the inherent ability of these stem cells to self-renew and the potential to differentiate into other cell types. Moreover, recent advances in cell-reprogramming and genome-editing technologies have provided additional tools for developing more effective and tailored stem-cell-based therapies.
This Special Issue aims to highlight stem-cell biology in both physiological and pathological conditions, thus expanding the current knowledge and boosting innovative diagnostic and/or therapeutic applications.
Original and review articles, including basic studies, are all welcome for consideration. Research topics may include (but are not limited to) the following:
- Molecular and cellular mechanisms governing stem-cell physiology, i.e., self-renewal signaling pathways, differentiation, and metabolic plasticity;
- Microenvironmental regulators of stem-cell plasticity and mutual interconversion between healthy and non-healthy stem cells;
- Cancer stem cell (CSC) involvement in tumor progression and molecular drivers and mechanisms underlying CSC therapy resistance;
- Therapeutic application of stem cells in experimental settings.
Dr. Maja Ludvigsen
Guest Editor
Manuscript Submission Information
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Keywords
- stem cell regulation
- differentiation
- pluripotency
- reprogramming
- stem cell therapy
- cancer stem cell/tumor-initiating cell
- therapy resistance
- regenerative medicine
- metabolic plasticity
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