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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Male Reproductive Physiology, Pathophysiology, and Contraception

edited by Gustavo G. Blanco

submission deadline 20 May 2026 | 2 articles | Viewed by 4751 | Submission Open

Keywords: spermatogenesis; spermiogenesis; testis; epididymis; sperm function; sperm motility; sperm capacitation; acrosome reaction; male reproduction; male fertility; male infertility; male contraception

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Arthritis: Focus on Pathologies, Symptoms and Therapy

edited by

Katarína Bauerová

submission deadline 20 May 2026 | 1 articles | Viewed by 4710 | Submission Open

Keywords: rheumatoid arthritis; autoimmune; pathogenesis; strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Dementia with Lewy Bodies and Alzheimer’s Disease

edited by

Kurt A. Jellinger

submission deadline 20 May 2026 | 2 articles | Viewed by 4700 | Submission Open

Keywords: dementia with Lewy bodies; Alzheimer’ s disease; dementing disorders in advanced age

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Ceramides and Ceramide Kinase

edited by Antonio Gomez-Muñoz

submission deadline 20 May 2026 | 3 articles | Viewed by 4637 | Submission Open

Keywords: cancer; cell survival; ceramides; ceramide 1-phosphate; inflammation

(This special issue belongs to the Section Biochemistry)

New Insights in Artificial Intelligence for Drug Design and Target Discovery

edited by

Yanjing Wang

submission deadline 20 May 2026 | 2 articles | Viewed by 4583 | Submission Open

Keywords: pre-trained language models; generative models; drug prediction; binding site prediction; peptides; multi-omics; deep learning; QSAR modeling; molecular dynamics (MD) simulations

(This special issue belongs to the Section Molecular Pharmacology)

Calcium Homeostasis of Cells in Health and Disease: Third Edition

edited by

Péter Szentesi

and

László Csernoch

submission deadline 20 May 2026 | 6 articles | Viewed by 4527 | Submission Open

Keywords: Ca2+; calcium homeostasis; calcium-binding proteins; aging; disease

(This special issue belongs to the Section Biochemistry)

Advancing Cancer Research: Molecular Insights, Diagnostic Innovations and Therapeutic Targets

edited by Jue Wang

submission deadline 20 May 2026 | 2 articles | Viewed by 4494 | Submission Open

Keywords: cancer; carcinogenesis; molecular pathology; signaling transduction; diagnosis; treatment; prognosis; pathogenesis; precision oncology; biomarker discovery; genomic profiling

(This special issue belongs to the Section Molecular Oncology)

Microbiome and Metabolome in the Gastrointestinal Tract, 3rd Edition

edited by

Ioannis Alexandros Charitos

submission deadline 20 May 2026 | 1 articles | Viewed by 4448 | Submission Open

Keywords: microbiome; dysbiosis; microbiology; immunity; cytokine/chemokine networks; microbiota axes pathways; toxic substances; autoimmunity

(This special issue belongs to the Section Molecular Biology)

Computational Approaches for Protein Design

edited by Livija Jakaite and

Mahesh Narayan

submission deadline 20 May 2026 | 4 articles | Viewed by 4426 | Submission Open

Keywords: computational protein design; molecular structure prediction; deep learning; protein structure and function prediction

(This special issue belongs to the Section Molecular Biophysics)

Liposomes: Molecular Marvels in Drug Delivery

edited by

Parkson Lee-Gau Chong

and Juyang Huang

submission deadline 20 May 2026 | 1 articles | Viewed by 4229 | Submission Open

Keywords: liposomal drug; targeted delivery; controlled release; hydrogen bonding; long-term stability; archaeosomes; cytotoxicity; lyophilized liposomal drugs

(This special issue belongs to the Section Molecular Biophysics)

The Role of Iodinated Compounds and Molecular Iodine in Human Disease

edited by

Carmen Aceves

submission deadline 20 May 2026 | 2 articles | Viewed by 4187 | Submission Open

Keywords: iodine; iodinated compounds; oxidized iodine; oxidized iodine supplement

(This special issue belongs to the Section Biochemistry)

Phytohormone Signaling and Crosstalk in Regulation of Plant Growth and Environmental Stress Responses: 2nd Edition

edited by

Lam-Son Phan Tran

and Mohammad G. Mostofa

submission deadline 20 May 2026 | 2 articles | Viewed by 4180 | Submission Open

Keywords: plant hormones; hormonal crosstalk; signal transduction; stress signaling; root system architecture; shoot branching; leaf development; phytohormone-responsive factors; transcriptional regulators; gene expression; plant physiology; senescence; plant plasticity; regulatory mechanisms; hormone homeostasis; stress adaptation/acclimatization

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights into Chemotherapeutic Agents in Cancer Treatment

edited by

Eleni Stamoula

submission deadline 20 May 2026 | 1 articles | Viewed by 4122 | Submission Open

Keywords: chemotherapy; molecular mechanisms; signal transduction; apoptosis; drug resistance; biomarkers; DNA damage; targeted therapy; cancer pathways; nanoparticles; nanomedicine; epigenetics

(This special issue belongs to the Section Molecular Pharmacology)

Liver Diseases: Causes, Molecular Mechanism and Treatment/Prevention

edited by

Munish Puri

submission deadline 20 May 2026 | 2 articles | Viewed by 3898 | Submission Open

Keywords: liver diseases; pathophysiology; molecular mechanisms; genetics and epigenetics; non-alcoholic fatty liver disease (NAFLD); hepatitis; liver injury and repair; gene therapy; pharmacological interventions; treatment and prevention; gut– liver axis; spleen– liver axis; alcoholic liver disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials for Tissue Regeneration: Current Progress and Future Directions

edited by

Ana Caruntu

and Horia Barbu

submission deadline 20 May 2026 | 2 articles | Viewed by 3896 | Submission Open

Keywords: biomaterials; biocompatibility; tissue engineering; tissue defect; rehabilitation; scaffolds; regenerative medicine; angiogenesis; stem cells; antimicrobial

(This special issue belongs to the Section Materials Science)

Evolution and Genomics: Relevance to Current Issues

edited by

Roger Dawkins

and Sally Lloyd

submission deadline 20 May 2026 | 2 articles | Viewed by 3884 | Submission Open

Keywords: paralogy; synteny; evolution; genomics; duplication; haplotype

(This special issue belongs to the Section Molecular Genetics and Genomics)

Challenges of Immune Checkpoint Inhibitor Therapy

edited by

Tibor Bakacs

submission deadline 20 May 2026 | 2 articles | Viewed by 3827 | Submission Open

Keywords: immune checkpoint inhibitor; ICI; safety of ICI drugs; irAE of ICI drugs; ultra-low-dose ICI; cost saving with ICI drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Thermodynamic and Spectral Studies of Complexes

edited by Michał Zabiszak

submission deadline 20 May 2026 | 4 articles | Viewed by 3747 | Submission Open

Keywords: spectroscopic techniques; molecular interaction; electronic spectroscopy; solid state chemistry; applications of complex compounds; reaction mechanism; catalytic activity

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Role of Metabolism-Related Pathways in Animal Growth, Development, Disease and Behavior

edited by

Runxiang Zhang

submission deadline 20 May 2026 | 4 articles | Viewed by 3736 | Submission Open

Keywords: metabolism pathway; signal pathway; animal development; animal behavior; animal disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Diagnostics in Neurological Diseases

edited by

Julián Benito-León

submission deadline 20 May 2026 | 2 articles | Viewed by 3727 | Submission Open

Keywords: neurological diseases; biomarkers; translational research; precision medicine; diagnosis; prognosis

(This special issue belongs to the Section Molecular Neurobiology)

Biomedical Polymer Materials: Design, Synthesis or Applications

edited by Lourdes Franco

submission deadline 20 May 2026 | 1 articles | Viewed by 3717 | Submission Open

Keywords: biomedical polymeric materials; nanoparticles; drug delivery; smart materials; hydrogels; tissue regeneration; therapeutic applications; dendrimers; MOFs; micelles

(This special issue belongs to the Section Materials Science)

Molecular Characterization of Plant–Microbe Interactions

edited by

Cristina Pinedo-Rivilla

submission deadline 20 May 2026 | 3 articles | Viewed by 3705 | Submission Open

Keywords: phytopathogen; plant pathology; phytopathogen fungi; phytopathogen bacteria; phytoalexins; plant defense; allelopathy; fungicides

(This special issue belongs to the Section Molecular Plant Sciences)

Advancing Molecular Science Through Reproducible qPCR: MIQE Guidelines and Beyond

edited by

Stephen Bustin

submission deadline 20 May 2026 | 3 articles | Viewed by 3689 | Submission Open

Keywords: MIQE; qPCR; reverse transcription

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Roles of Diet and Nutrition in Metabolic Diseases: Advancements in Molecular Insights

edited by Ramos-López Omar

submission deadline 20 May 2026 | 2 articles | Viewed by 3633 | Submission Open

Keywords: diet; nutrition; metabolic diseases; obesity; genetics; microbiota; epigenetics; metabolomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Molecular Basis of Extracellular Vesicles in Health and Diseases—2nd Edition

edited by Taral R. Lunavat

submission deadline 20 May 2026 | 3 articles | Viewed by 3618 | Submission Open

Keywords: exosomes; microvesicles; extracellular vesicles; genetic material; therapeutics; diagnostics; biomarkers; molecular pathway; liquid biopsy; metabolism; omics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Prostate Diseases: Focus on Hormone Therapies and Targeted Interventions

edited by Gabriel Campolina-Silva and Héctor Contreras

submission deadline 20 May 2026 | 1 articles | Viewed by 3615 | Submission Open

Keywords: urinary disease; prostate cancer; hormone; therapeutic strategy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Medical Applications of Polymer Materials

edited by Zhen Zhang

submission deadline 20 May 2026 | 2 articles | Viewed by 3545 | Submission Open

Keywords: medical polymers; drug delivery; tissue engineering; medical devices; diagnostics

(This special issue belongs to the Section Macromolecules)

RNA Editing/Modification in Health and Disease

edited by Valeriana Cesarini and

Piergiorgio La Rosa

submission deadline 20 May 2026 | 2 articles | Viewed by 3540 | Submission Open

Keywords: RNA editing; RNA transport and localization; miRNAs; siRNAs; lncRNAs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Whole-Cell System and Synthetic Biology, 2nd Edition

edited by

Jingjing Tian

submission deadline 20 May 2026 | 2 articles | Viewed by 3529 | Submission Open

Keywords: synthesis biology; molecular biology; functional nucleic acids; biosensor; CRISPR-Cas; directed evolution; whole-cell system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Peptides and Peptidomimetics for Targeting Protein-Protein Interactions

edited by

Giacomo Rossino

and

Pasquale Linciano

submission deadline 20 May 2026 | 1 articles | Viewed by 3471 | Submission Open

Keywords: protein– protein interactions; peptide– protein interactions; interactome; proteomics; peptides; modified peptides; peptidomimetics; molecular glues; drug discovery; medicinal chemistry; rule of five; biophysical assays; molecular modelling; cancer; neurodegenerative diseases; orphan diseases; antimicrobial resistance; PROTAC

(This special issue belongs to the Section Biochemistry)

Effects of Ionizing Radiation in Cancer Radiotherapy: 2nd Edition

edited by

François Chevalier

submission deadline 20 May 2026 | 2 articles | Viewed by 3387 | Submission Open

Keywords: non-targeted effects; radiation-induced bystander effect; abscopal effect; genomic instability; low dose effects; radioprotection; circulating biomarkers; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cyclodextrins for Drug/iRNA Co-Delivery

edited by

Ivana Jarak

and

Ana Figueiras

submission deadline 20 May 2026 | 1 articles | Viewed by 3364 | Submission Open

Keywords: advanced therapies; antibody-based therapies; active and passive tumor targeting; cancer; conventional chemotherapy; immune system; immunotherapy; immunotoxicity; nanomedicine; nanoparticles; nanotoxicity; tumor immune microenvironment (TIME); tumor microenvironment (TME); cyclodextrins

(This special issue belongs to the Section Macromolecules)

Molecular Insights into Flower Gene Regulation

edited by Wen‑Chieh Tsai

submission deadline 20 May 2026 | 2 articles | Viewed by 3257 | Submission Open

Keywords: floral gene regulation; flowers; homeotic genes; MADSBox; pollination

(This special issue belongs to the Section Molecular Plant Sciences)

Plant Biology and Biotechnology: Focus on Genomics, Bioinformatics and AI

edited by

Yuriy L. Orlov

and

Ming Chen

submission deadline 20 May 2026 | 1 articles | Viewed by 3201 | Submission Open

Keywords: gene expression regulation in plants; ncRNA and gene editing in plants; AI applications in plant bioinformatics; molecular mechanisms of stress resistance in plants; ncRNA and gene editing in plants; plant– pathogen interactions; systems biology and ecological networks for agrobiology; next-generation sequencing in plants; modeling of plant cell growth; gene networks and pathway modeling in plants; computer phenotyping of plants

(This special issue belongs to the Section Molecular Informatics)

Molecular Pathways, Microbiome, and Chronic Inflammatory Skin Diseases: Bridging the Gap

edited by

Oliver Seifert

submission deadline 20 May 2026 | 1 articles | Viewed by 3189 | Submission Open

Keywords: psoriasis; skin microbiome; chronic inflammatory skin diseases; molecular pathogenesis; biomarkers

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms, Biomarkers, and Therapeutic Targets for Endometriosis

edited by Katharina Proestling and

Iveta Yotova

submission deadline 20 May 2026 | 2 articles | Viewed by 3180 | Submission Open

Keywords: endometriosis; biomarkers; inflammation; fibrosis; oxidative stress; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Host-Virus Interaction

edited by

Xiaohui Ju

and

Xupeng Hong

submission deadline 20 May 2026 | 2 articles | Viewed by 3129 | Submission Open

Keywords: viral entry; viral replication; virus assembly and release; pro-viral factors; restriction factors; interferon pathway; viral immune evasion; antiviral strategies

(This special issue belongs to the Section Molecular Immunology)

Osteoarthritis: From Pathophysiology to Novel Therapy

edited by

Paloma Guillem-Llobat

submission deadline 20 May 2026 | 2 articles | Viewed by 3056 | Submission Open

Keywords: osteoarthritis; therapeutic targets; molecular mechanisms; biomarkers; bone degenerative disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Targets in Cardiovascular Health and Cardiotoxicity

edited by

Rui Vitorino

submission deadline 20 May 2026 | 2 articles | Viewed by 2950 | Submission Open

Keywords: cardiovascular; ischemia; heart failure; arrhythmogenesis; myocardial remodeling; endothelial dysfunction; cardiology; cardio-oncology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lymphedema: From Mechanism to Treatment

edited by

Florent Morfoisse

submission deadline 20 May 2026 | 1 articles | Viewed by 2851 | Submission Open

Keywords: lymphedema; lymphatic dysfunction; molecular mechanisms; cell signaling; diagnostic imaging; biomarkers; therapeutic interventions; inflammation; adipose tissue accumulation; fibrosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarkers in Diabetes Mellitus: From Discovery to Clinical Application

edited by

Jelena Vekic

and

Aleksandra Zeljkovic

submission deadline 20 May 2026 | 2 articles | Viewed by 2840 | Submission Open

Keywords: diabetes mellitus; biomarkers; diabetes complications; omics technologies; risk stratification; therapeutic response; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Computational Research in Pharmacological Structure–Efficacy

edited by

José Rogério A. Silva

and Jerônimo Lameira

submission deadline 20 May 2026 | 2 articles | Viewed by 2798 | Submission Open

Keywords: molecular modeling; structure– activity relationship (SAR); pharmacological efficacy; quantum chemistry; molecular dynamics; free energy calculations; drug design; enzyme inhibition; ligand– receptor interactions; computational pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Advances in the Pathophysiology and Treatment of Eye Diseases

edited by

Georgios Panos

submission deadline 20 May 2026 | 2 articles | Viewed by 2743 | Submission Open

Keywords: ocular pathophysiology; eye diseases; molecular mechanisms; biomolecular pathways; therapeutic targets; translational ophthalmology; retinal degeneration; oxidative stress in ocular disorders; angiogenesis in eye diseases; neuroprotection in ophthalmology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Glial Cells in Neurodegenerative Disorders

edited by Daniel Souza Monteiro de Araujo

submission deadline 20 May 2026 | 2 articles | Viewed by 2739 | Submission Open

Keywords: glial cells; microglia; astrocytes; oligodendrocytes; neurodegenerative disorders

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Graphene-Based Nanocomposites and Perspectives on Their Design

edited by Aleksey E. Kuznetsov

submission deadline 20 May 2026 | 2 articles | Viewed by 2687 | Submission Open

Keywords: graphene; graphene oxide; nanocomposite; synthesis; computational study; characterization; application; design

(This special issue belongs to the Section Molecular Nanoscience)

Cancer-Driving Molecules: From Molecular Mechanisms to Novel Therapeutics

edited by

Georgios Pantouris

submission deadline 20 May 2026 | 2 articles | Viewed by 2640 | Submission Open

Keywords: cancer; mechanism of action; tumor microenvironment; immune system; DNA/RNA/protein; small-molecule probes; activation/inhibition; biological activity

(This special issue belongs to the Section Molecular Oncology)

Bioactive Food Compounds in the Prevention and Treatment of Non-Communicable Diseases

edited by

Aneta Kopeć

submission deadline 20 May 2026 | 1 articles | Viewed by 2625 | Submission Open

Keywords: bioactive compounds; dietary fiber; polyphenols; sulfur compounds; antioxidant; reduce oxidative stress; inflammation; non-communicable diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Antisense Oligonucleotides: Versatile Tools with Broad Applications

edited by

Suxiang Chen

submission deadline 20 May 2026 | 2 articles | Viewed by 2586 | Submission Open

Keywords: antisense oligonucleotide; RNase H; splice switching; exon skipping; therapeutics; pesticide

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in the Synthesis and Medical Application of Biomaterials

edited by

Csaba Balázsi

submission deadline 20 May 2026 | 1 articles | Viewed by 2547 | Submission Open

Keywords: nanostructured biomaterials; bioceramics; bioactive; biodegradable; resorbable materials; biomimetic materials; biocompatibility

(This special issue belongs to the Section Materials Science)

Next-Generation Hydrogels: Innovations in Biofunctionalization and Personalization for Targeted Biomedical Therapies

edited by

Siu Hong Dexter Wong

and Bohan Yin

submission deadline 20 May 2026 | 1 articles | Viewed by 2537 | Submission Open

Keywords: biofunctionalization hydrogels; personalized hydrogels; smart hydrogel development; 3D/4D bioprinting of hydrogels; AI-driven hydrogel design; dynamic hydrogel systems; hydrogel-based vaccines and immunotherapies; smart hydrogels for controlled release

(This special issue belongs to the Section Macromolecules)

Displaying special issue 2651-2700 on page 54 of 68.

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