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Biomedical Polymer Materials: Design, Synthesis or Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 20 May 2026 | Viewed by 4843

Special Issue Editor


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Guest Editor
Departament d’Enginyeria Química, Universitat Politècnica de Catalunya, Escola d’Enginyeria de Barcelona Est-EEBE, c/Eduard Maristany 10-14, 08019 Barcelona, Spain
Interests: biodegradable and synthetic polymers; polymer crystallization; thermal properties; spherulites

Special Issue Information

Dear Colleagues,

The importance of biomedical research lies mainly in the fact that this knowledge allows the development of advanced therapies, medications and innovative therapeutic solutions. The boost in research in the biomedical field has been great due to the advancement of biotechnology and medical technology and particularly the use of new and innovative materials.

Due to their biocompatibility and non-toxic nature, polymeric materials are the best choice in this field. These materials can be tailor-designed for a wide range of applications from tissue engineering and gene/drug delivery to medical devices, including tissue adhesives, implants and surgical suture and meshes. The drive to find and design new polymeric materials and advance the biomedical field is becoming unstoppable. The search for more advanced materials with sophisticated performance may include hydrogels, nanoparticles, smart materials, dendrimers, polymer/metal organic framework (MOF) nanocomposites, polymeric micelles and polymeric nanogels, among others.

This Special Issue of the International Journal of Molecular Science aims to discuss, collect and present recent highlights and advances on new polymers for biomedical applications, covering their synthesis, design, properties and uses. To this end, the progress in the development of the synthesis process, the study of their structure, the evaluation of the responsiveness under different external stimuli (i.e. smart polymers) and the study of applications in biomedicine and materials science are some of the specific topics that should be considered.

Dr. Lourdes Franco
Guest Editor

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Keywords

  • biomedical polymeric materials
  • nanoparticles
  • drug delivery
  • smart materials
  • hydrogels
  • tissue regeneration
  • therapeutic applications
  • dendrimers
  • MOFs
  • micelles

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Published Papers (2 papers)

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Review

29 pages, 1340 KB  
Review
Extracellular Polymeric Substances Produced by Actinomycetes of the Genus Rhodococcus for Biomedical and Environmental Applications
by Anastasiia Krivoruchko, Daria Nurieva and Irina Ivshina
Int. J. Mol. Sci. 2026, 27(1), 498; https://doi.org/10.3390/ijms27010498 - 3 Jan 2026
Viewed by 382
Abstract
Extracellular polymeric substances (EPSs) produced by actinomycetes of the genus Rhodococcus play crucial roles in their ecological success, metabolic versatility, and biotechnological value. This review summarizes existing studies of Rhodococcus EPSs, emphasizing the biochemical composition, functional attributes, and practical significance of EPSs, as [...] Read more.
Extracellular polymeric substances (EPSs) produced by actinomycetes of the genus Rhodococcus play crucial roles in their ecological success, metabolic versatility, and biotechnological value. This review summarizes existing studies of Rhodococcus EPSs, emphasizing the biochemical composition, functional attributes, and practical significance of EPSs, as well as their importance in biomedicine, bioremediation, and other applications (food industry, biomineralization) with respect to the EPS chemical composition and biological roles. Rhodococcus species synthesize complex EPSs composed primarily of polysaccharides, proteins and lipids that, like in other bacteria, support cell adhesion, aggregation, biofilm formation, and horizontal gene transfer (and can prevent exogenous DNA binding) and are highly important for resistance against toxicants and dissolution/assimilation of hydrophobic compounds. EPSs produced by different species of Rhodococcus exhibit diverse structures (soluble EPSs, loosely bound and tightly bound fractions, capsules, linear and branched chains, amorphous coils, rigid helices, mushroom-like structures, extracellular matrix, and a fibrillar structure with a sheet-like texture), leading to variations in their properties (rheological features, viscosity, flocculation, sorption abilities, compression, DNA binding, and interaction with hydrophobic substrates). Notably, the EPSs exhibit marked emulsifying and flocculating properties, contributing to their recognized role in bioremediation. Furthermore, EPSs possess antiviral, antibiofilm, anti-inflammatory, and anti-proliferating activities and high viscosity, which are valuable in terms of biomedical and food applications. Despite extensive industrial and environmental interest, the molecular regulation, biosynthetic pathways, and structural diversity of Rhodococcus EPSs remain insufficiently characterized. Advancing our understanding of these biopolymers could expand new applications in biomedicine, bioremediation, and biotechnology. Full article
(This article belongs to the Special Issue Biomedical Polymer Materials: Design, Synthesis or Applications)
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23 pages, 1324 KB  
Review
Engineered Healing: Synergistic Use of Schwann Cells and Biomaterials for Spinal Cord Regeneration
by Theo Andriot, Mousumi Ghosh and Damien D. Pearse
Int. J. Mol. Sci. 2025, 26(16), 7922; https://doi.org/10.3390/ijms26167922 - 16 Aug 2025
Cited by 4 | Viewed by 3830
Abstract
Spinal cord injury (SCI) remains a devastating neurological condition characterized by loss of sensory, motor and autonomic function. Despite decades of research, no FDA-approved regenerative therapies currently exist to restore lost function following SCI. Schwann cells (SCs) support axon regeneration, remyelination, and neuroprotection [...] Read more.
Spinal cord injury (SCI) remains a devastating neurological condition characterized by loss of sensory, motor and autonomic function. Despite decades of research, no FDA-approved regenerative therapies currently exist to restore lost function following SCI. Schwann cells (SCs) support axon regeneration, remyelination, and neuroprotection after SCI, with their therapeutic potential validated in clinical trials demonstrating safe and feasible transplantation in humans. Although SC transplantation has shown promising results, challenges remain, including modest graft survival, limited host integration, and restricted migration that collectively contribute to constrain efficacy. To address these limitations, biomaterial scaffolds have been explored as synergistic platforms to enhance SC delivery and function. When combined with natural or synthetic biomaterials such as hydrogels, nanofiber scaffolds, or ECM-mimetic matrices, SCs demonstrate improved survival, retention, spatial distribution, and regenerative activity. The intrinsic regenerative properties of SCs, first demonstrated in models of peripheral nerve injury, make them particularly well-suited for neural repair of the central nervous system (CNS) compared to other cell types and their effectiveness can be enhanced synergistically when combined with biomaterials. These constructs not only provide structural support but also modulate the lesion microenvironment, enhance axon growth and improve SC integration with host tissue. Combinatorial approaches incorporating biomaterials with SCs are emerging as next-generation strategies to optimize repair for clinical translation. This review focuses on current progress in SC-based therapies combined with biomaterials, highlighting key preclinical advances, clinical translation efforts, and the path forward toward effective regenerative interventions for SCI. Full article
(This article belongs to the Special Issue Biomedical Polymer Materials: Design, Synthesis or Applications)
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