The Role of Iodinated Compounds and Molecular Iodine in Human Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 445
Special Issue Editor
Special Issue Information
Dear Colleagues,
Iodine, in its various chemical forms, is essential for most living organisms and considered a micronutrient in chordates. In vertebrates, iodine is a vital component of thyroid hormones, crucial for the proper development and functioning of several organs, particularly in the nervous system. However, a significant amount of iodine in the body is non-hormonal and concentrated in extra-thyroid tissues, where its biological function is not well understood. Some scientific groups have suggested that iodine may have an outdated antioxidant function in all the cells that concentrate it, from primitive algae to recent vertebrates. In these cells, oxidized iodine can act as an electron donor, neutralizing reactive oxygen species (ROS), or attach to the double bonds of certain polyunsaturated fatty acids in cell membranes, making them less reactive to ROS. Additionally, it has been demonstrated that iodine binds to lipids, such as arachidonic acid, induces apoptosis, and has differentiation effects on various cancer cells. Furthermore, iodine is taken up and metabolized by immune cells, and depending on the physiological context, this halogen can act as an anti-inflammatory or pro-inflammatory agent.
Recently, the I2 supplement prevented and normalized metabolic alterations in a diabetic mouse model induced with streptozotocin, preserving the morphology of pancreatic, liver, muscle, and adipose tissues and promoting the abundance of beneficial bacteria that support the integrity of the intestinal epithelial barrier and higher α-diversity. This Special Issue aims to provide an overview of “The Role of Iodinated Compounds and Molecular Iodine in Human Disease” and their potential applications.
Dr. Carmen Aceves
Guest Editor
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Keywords
- iodine
- iodinated compounds
- oxidized iodine
- oxidized iodine supplement
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