Glial Cells in Neurodegenerative Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 164
Special Issue Editor
Special Issue Information
Dear Colleagues,
Glial cells, including microglia, astrocytes, and oligodendrocytes, play a critical role in maintaining neuronal health, modulating inflammation, and responding to injury in the central nervous system. However, in neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS), glial cell dysfunction and chronic activation contribute to disease progression through inflammatory and oxidative stress pathways. Microglial activation often leads to the release of pro-inflammatory cytokines and reactive oxygen species, exacerbating neural damage. On the other hand, astrocyte reactivity can disrupt synaptic balance and contribute to neuronal degeneration. Understanding how glial cell dysregulation drives neurodegenerative processes is essential to developing novel therapies.
This Special Issue aims to explore the diverse roles of glial cells in neurodegenerative diseases, with a focus on mechanisms by which glial cell activation contributes to neurodegeneration; the role of glial cells in synaptic dysfunction and neuronal survival; potential therapeutic targets within glial signaling pathways for neurodegenerative conditions. This Special Issue aims to advance our understanding of glial cell involvement in neurodegeneration, paving the way for innovative glia-focused therapies.
Dr. Daniel Souza Monteiro de Araujo
Guest Editor
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Keywords
- glial cells
- microglia
- astrocytes
- oligodendrocytes
- neurodegenerative disorders
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