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Molecular Advances in the Synthesis and Medical Application of Biomaterials
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Molecular Advances in the Synthesis and Medical Application of Biomaterials

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 20 May 2026 | Viewed by 3555

Special Issue Editor

Dr. Csaba Balázsi

E-Mail Website
Guest Editor
Centre for Energy Research, Institute of Technical Physics and Materials Science, Konkoly-Thege Str. 29-33, 1121 Budapest, Hungary
Interests: ceramic processing; nano-milling; hydrothermal; powder metallurgy; sintering; electrospinning
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue focuses on topics covering the molecular advances in processing of novel biomaterials, the synthesis of bio-hybrids and bioactive or bioresorbable materials at the molecular level, and the study of their biodegradability and biocompatibility. The field of biomaterials and their biocomposites has advanced significantly to restore, substitute, or regenerate not only skeletal hard but also soft tissues. These innovative materials have been studied to be applied for orthopaedic implants, bone substitutes, bone cements, dental prostheses, drug delivery carriers, and even for cancer treatments. In addition, the development and use of nanostructured materials, biomimetic materials, and inorganic–organic structures resulted in considerable scientific interest in the biomaterials field. Contributions on innovative approaches such as the additive manufacturing of biomaterials, bioceramics, biodegradable materials, biocomposites, layer deposition techniques, tissue engineering, and drug delivery systems are also welcome.

Dr. Csaba Balázsi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanostructured biomaterials
  • bioceramics
  • bioactive
  • biodegradable
  • resorbable materials
  • biomimetic materials
  • biocompatibility

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Published Papers (2 papers)

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Research

22 pages, 5707 KB  
Article
Three-Dimensional Culture of Primary Hepatocytes in a Single-Cell Layer on Poly(vinyl alcohol) Nanofibrous Membrane
by Hue Vy An Tran, Song-Hee Han, Thi Xuan Thuy Tran, Kwan Woo Kim, Min Chan Kim, In-Jeong Lee and Jong-Young Kwak
Int. J. Mol. Sci. 2026, 27(5), 2366; https://doi.org/10.3390/ijms27052366 - 3 Mar 2026
Viewed by 453
Abstract
Primary hepatocyte cultures serve as an ex vivo model of liver physiology. This study aims to employ poly(vinyl alcohol) (PVA) nanofiber membranes (NMs) to establish a three-dimensional (3D) culture system that supports the long-term functionality of primary hepatocytes. Primary hepatocytes were monocultured on [...] Read more.
Primary hepatocyte cultures serve as an ex vivo model of liver physiology. This study aims to employ poly(vinyl alcohol) (PVA) nanofiber membranes (NMs) to establish a three-dimensional (3D) culture system that supports the long-term functionality of primary hepatocytes. Primary hepatocytes were monocultured on a PVA NM or indirectly cocultured with NIH3T3 fibroblasts on a distinct polycaprolactone (PCL) NM layer. Monocultured and cocultured hepatocytes maintained prolonged survival without supplemental growth factors. Cocultured hepatocytes formed larger aggregates composed of cell clusters attached to untreated nanofibers than monocultured cells. However, most primary hepatocytes cultured on NaOH-treated PVA NM and Arg–Gly–Asp (RGD) peptide-blended PVA (RGD-PVA) NM, under monoculture and coculture conditions, formed non-aggregated cells in a single-cell layer. In a bioinert assay, unstimulated dendritic cells were activated on untreated but not NaOH-treated PVA NM. CYP3A4 activity was higher in cocultured cells on RGD-PVA NM with fibroblasts than in monocultured cells on PVA and RGD-PVA NM. Functional hepatocyte cultures were successfully maintained in a 3D single-cell layer on RGD-PVA NM, along with fibroblasts in a layer-by-layer coculture, for a prolonged period. The prolonged culture of hepatocytes in a 3D single-cell layer may facilitate further drug discovery, toxicity studies, and translational liver research. Full article
(This article belongs to the Special Issue Molecular Advances in the Synthesis and Medical Application of Biomaterials)
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15 pages, 10134 KB  
Article
Investigation of Calcium Phosphate-Based Biopolymer Composite Scaffolds for Bone Tissue Engineering
by Monika Furko, Zsolt E. Horváth, Istvan Tolnai, Katalin Balázsi and Csaba Balázsi
Int. J. Mol. Sci. 2024, 25(24), 13716; https://doi.org/10.3390/ijms252413716 - 22 Dec 2024
Cited by 5 | Viewed by 2373
Abstract
We present a novel method for preparing bioactive and biomineralized calcium phosphate (mCP)-loaded biopolymer composite scaffolds with a porous structure. Two types of polymers were investigated as matrices: one natural, cellulose acetate (CA), and one synthetic, polycaprolactone (PCL). Biomineralized calcium phosphate particles were [...] Read more.
We present a novel method for preparing bioactive and biomineralized calcium phosphate (mCP)-loaded biopolymer composite scaffolds with a porous structure. Two types of polymers were investigated as matrices: one natural, cellulose acetate (CA), and one synthetic, polycaprolactone (PCL). Biomineralized calcium phosphate particles were synthesized via wet chemical precipitation, followed by the addition of organic biominerals, such as magnesium gluconate and zinc gluconate, to enhance the bioactivity of the pure CP phase. We compared the morphological and chemical characteristics of the two types of composites and assessed the effect of biomineralization on the particle structure of pure CP. The precipitated CP primarily consisted of nanocrystalline apatite, and the addition of organic trace elements significantly influenced the morphology by reducing particle size. FE-SEM elemental mapping confirmed the successful incorporation of mCP particles into both CA and PCL polymer matrices. Short-term immersion tests revealed that the decomposition rate of both composites is slow, with moderate and gradual ionic dissolution observed via ICP-OES measurements. The weight loss of the PCL-based composite during immersion was minimal, decreasing by only 0.5%, while the CA-based composite initially exhibited a slight weight increase before gradually decreasing over time. Full article
(This article belongs to the Special Issue Molecular Advances in the Synthesis and Medical Application of Biomaterials)
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