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Molecular Advances in the Synthesis and Medical Application of Biomaterials

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 1633

Special Issue Editor


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Guest Editor
Centre for Energy Research, Institute of Technical Physics and Materials Science, Konkoly-Thege Str. 29-33, 1121 Budapest, Hungary
Interests: ceramic processing; nano-milling; hydrothermal; powder metallurgy; sintering; electrospinning
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Special Issue Information

Dear Colleagues,

The Special Issue focuses on topics covering the molecular advances in processing of novel biomaterials, the synthesis of bio-hybrids and bioactive or bioresorbable materials at the molecular level, and the study of their biodegradability and biocompatibility. The field of biomaterials and their biocomposites has advanced significantly to restore, substitute, or regenerate not only skeletal hard but also soft tissues. These innovative materials have been studied to be applied for orthopaedic implants, bone substitutes, bone cements, dental prostheses, drug delivery carriers, and even for cancer treatments. In addition, the development and use of nanostructured materials, biomimetic materials, and inorganic–organic structures resulted in considerable scientific interest in the biomaterials field. Contributions on innovative approaches such as the additive manufacturing of biomaterials, bioceramics, biodegradable materials, biocomposites, layer deposition techniques, tissue engineering, and drug delivery systems are also welcome.

Dr. Csaba Balázsi
Guest Editor

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Keywords

  • nanostructured biomaterials
  • bioceramics
  • bioactive
  • biodegradable
  • resorbable materials
  • biomimetic materials
  • biocompatibility

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Published Papers (1 paper)

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Research

15 pages, 10134 KiB  
Article
Investigation of Calcium Phosphate-Based Biopolymer Composite Scaffolds for Bone Tissue Engineering
by Monika Furko, Zsolt E. Horváth, Istvan Tolnai, Katalin Balázsi and Csaba Balázsi
Int. J. Mol. Sci. 2024, 25(24), 13716; https://doi.org/10.3390/ijms252413716 - 22 Dec 2024
Cited by 1 | Viewed by 1225
Abstract
We present a novel method for preparing bioactive and biomineralized calcium phosphate (mCP)-loaded biopolymer composite scaffolds with a porous structure. Two types of polymers were investigated as matrices: one natural, cellulose acetate (CA), and one synthetic, polycaprolactone (PCL). Biomineralized calcium phosphate particles were [...] Read more.
We present a novel method for preparing bioactive and biomineralized calcium phosphate (mCP)-loaded biopolymer composite scaffolds with a porous structure. Two types of polymers were investigated as matrices: one natural, cellulose acetate (CA), and one synthetic, polycaprolactone (PCL). Biomineralized calcium phosphate particles were synthesized via wet chemical precipitation, followed by the addition of organic biominerals, such as magnesium gluconate and zinc gluconate, to enhance the bioactivity of the pure CP phase. We compared the morphological and chemical characteristics of the two types of composites and assessed the effect of biomineralization on the particle structure of pure CP. The precipitated CP primarily consisted of nanocrystalline apatite, and the addition of organic trace elements significantly influenced the morphology by reducing particle size. FE-SEM elemental mapping confirmed the successful incorporation of mCP particles into both CA and PCL polymer matrices. Short-term immersion tests revealed that the decomposition rate of both composites is slow, with moderate and gradual ionic dissolution observed via ICP-OES measurements. The weight loss of the PCL-based composite during immersion was minimal, decreasing by only 0.5%, while the CA-based composite initially exhibited a slight weight increase before gradually decreasing over time. Full article
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