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Advances in the Pathophysiology and Treatment of Eye Diseases
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Advances in the Pathophysiology and Treatment of Eye Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 December 2025 | Viewed by 1123

Special Issue Editor

Dr. Georgios Panos

E-Mail Website
Guest Editor
1. Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece
2. Division of Ophthalmology and Visual Sciences, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK
Interests: ophthalmology; retina; vitreoretinal surgery; medical retina; molecular biology in ophthalmology; ocular pharmacology; ophthalmic surgery; biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are delighted to invite submissions to a Special Issue titled "Advances in the Pathophysiology and Treatment of Eye Diseases", focusing on the molecular mechanisms underlying ocular disorders and innovative approaches for their management.

This Special Issue aims at exploring the intersection of molecular science and ophthalmology, highlighting recent advancements in understanding the biomolecular pathways involved in eye diseases and the translational potential of these findings in developing novel treatments.

We welcome original research articles, comprehensive reviews, and cutting-edge experimental studies that provide insights into the following:

  • Molecular mechanisms driving ocular pathophysiology;
  • Biomolecular pathways targeted in innovative therapeutic interventions;
  • Translational studies combining biomolecular experiments with clinical relevance;
  • Advanced model systems (in vitro or in vivo) designed to study eye diseases.

Please note: As this is a journal of molecular science, purely clinical studies are not suitable for this Special Issue. However, submissions bridging clinical and molecular research through biomolecular experimentation or advanced modeling are highly encouraged.

By contributing to this Special Issue, authors will have the opportunity to shape the understanding of eye disease pathophysiology and influence the development of future treatment strategies.

The deadline for submissions is 30/05/2025. For detailed submission guidelines, please visit our website: https://www.mdpi.com/journal/ijms/special_issues/N6722OS3R7.

Dr. Georgios Panos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ocular pathophysiology
  • eye diseases
  • molecular mechanisms
  • biomolecular pathways
  • therapeutic targets
  • translational ophthalmology
  • retinal degeneration
  • oxidative stress in ocular disorders
  • angiogenesis in eye diseases
  • neuroprotection in ophthalmology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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17 pages, 1006 KB  
Review
Pregnancy and Dry Eye Syndrome: A Review for Clinical Practice
by Marta Jaruchowska, Joanna Przybek-Skrzypecka and Janusz Skrzypecki
Int. J. Mol. Sci. 2025, 26(20), 9990; https://doi.org/10.3390/ijms26209990 - 14 Oct 2025
Viewed by 397
Abstract
Pregnancy is a unique physiological state associated with profound hormonal, metabolic, and immunological changes that may affect ocular surface homeostasis. Among these changes, fluctuations in estrogen and progesterone are the most consistent factors contributing to the development or exacerbation of dry eye syndrome [...] Read more.
Pregnancy is a unique physiological state associated with profound hormonal, metabolic, and immunological changes that may affect ocular surface homeostasis. Among these changes, fluctuations in estrogen and progesterone are the most consistent factors contributing to the development or exacerbation of dry eye syndrome (DES), although insulin resistance and maternal immune tolerance may also play a role in modulating disease severity. Current evidence suggests that DES can affect between 20% and 50% of pregnant women, most commonly during the second and third trimesters. Symptoms are often mild and self-limiting, but they can negatively impact quality of life and adherence to prenatal care. Importantly, however, current consensus reports such as TFOS DEWS III emphasize that pregnancy has not been established as a confirmed risk factor for DES and the evidence remains inconclusive despite the biological plausibility of hormonal influences. This review summarizes the pathophysiological mechanisms underlying DES in pregnancy, highlights diagnostic approaches and safe management strategies tailored for pregnant women, and emphasizes the importance of awareness among obstetricians and ophthalmologists. Greater recognition of DES in pregnancy may improve patient comfort and prevent long-term ocular complications. Full article
(This article belongs to the Special Issue Advances in the Pathophysiology and Treatment of Eye Diseases)
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13 pages, 1343 KB  
Article
Diagnostic Performance of Universal Transport Medium for Viral Polymerase Chain Reaction in Aqueous Humor Samples of Suspected Viral Uveitis: A Pilot Methods Study
by Chungwoon Kim, Yoo-Ri Chung, Ji Hun Song, Young Joon Choi and Hae Rang Kim
Int. J. Mol. Sci. 2025, 26(20), 10091; https://doi.org/10.3390/ijms262010091 - 16 Oct 2025
Viewed by 198
Abstract
We investigated the diagnostic efficacy of the universal transport medium™ (UTM®) as a transport medium for aqueous humor polymerase chain reaction (PCR) testing in patients with clinically suspected viral uveitis. This retrospective study included 31 patients (31 eyes) with presumed viral [...] Read more.
We investigated the diagnostic efficacy of the universal transport medium™ (UTM®) as a transport medium for aqueous humor polymerase chain reaction (PCR) testing in patients with clinically suspected viral uveitis. This retrospective study included 31 patients (31 eyes) with presumed viral uveitis who underwent anterior chamber sampling and compared the viral detection rates between using UTM® and conventional test tubes only. The positivity rate for any virus, including cytomegalovirus, herpes simplex virus, and varicella zoster virus, was significantly higher in the UTMT® group than in the test tube group (64.3% vs. 23.5%, p = 0.033). Logistic regression analysis also revealed that the use of UTM® significantly increased the PCR positivity rate (odds ratio, 5.850; 95% confidence interval, 1.222–27.994; p = 0.027). Thus, the use of UTM® was associated with improved detection of causative pathogens in patients with presumed viral uveitis. Full article
(This article belongs to the Special Issue Advances in the Pathophysiology and Treatment of Eye Diseases)
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