Background: Biologic and small-molecule therapies have transformed inflammatory bowel disease (IBD) management, yet real-world evidence from the Gulf region remains limited. This study evaluated 12-month clinical, biochemical, and endoscopic outcomes...
Mucinous adenocarcinoma (MAC) is a distinct colorectal cancer subtype characterized by specific clinicopathological and molecular features and a propensity for peritoneal dissemination. However, whether mucinous histology primarily represents a progn...
Background: Pancreatic carcinomas are among the malignant tumours with the highest mortality and remain associated with an extremely poor prognosis. Early identification and surveillance of premalignant lesions, such as intraductal papillary mucinous...
Background/Objectives: Transanal irrigation (TAI) is an established bowel-emptying strategy for selected patients with bowel dysfunction, whereas evidence on Colon Hydrotherapy (CHT) in chronic gastrointestinal disorders remains limited. This pilot s...
Background/Objectives: Contemporary data on active Helicobacter pylori infection among university students in Albania are limited. This study estimated urea breath test (UBT)-detected prevalence and described awareness, self-reported knowledge, gastr...
Background: Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are considered major causes of cancer-related mortality. Evidence suggests that gut microbiome dysbiosis and the microbial–metabolic axis and its metabolites in hepatic chr...
Although overall colorectal cancer (CRC) incidence and mortality have declined with widespread screening, early-onset CRC (EOCRC), defined as diagnosis before age 50, continues to rise. EOCRC partially differs from late-onset CRC (LOCRC) in clinical...
Obesity is a chronic inflammatory condition whose rising incidence has turned it into a global epidemic, a trend that also affects people living with inflammatory bowel diseases (IBD). Recent epidemiological data indicate that roughly 25 to 40% of pa...
Background/Objectives: Amyloid deposition is an uncommon but clinically important complication of chronic inflammatory disorders, including inflammatory bowel disease (IBD). Because published estimates are heterogeneous and depend strongly on how tis...
29 September 2026
Pancreatic ductal adenocarcinoma (PDAC) is defined by significant desmoplastic reaction composed of cancer-associated fibroblasts (CAFs), pancreatic stellate cells (PSCs), extracellular matrix (ECM), immune cells, and abnormal vascularization. This s...
24 September 2026
Background/Objectives: Adenoma detection rate (ADR) is a central colonoscopy quality indicator, but the extent to which annual procedural volume explains physician-level ADR remains uncertain. We evaluated the association of procedural volume with AD...
16 September 2026
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease in children and adolescents, paralleling the global increase in pediatric obesity. Despite its growing clinical impact, the diagnosis an...
10 September 2026
Background/Objective: The standard first-line treatment for advanced or recurrent gastric cancer (AGC) includes chemotherapy combined with an immune checkpoint inhibitor or zolbetuximab, but delivering fluoropyrimidine-platinum chemotherapy at standa...
Background: The Warburg effect is a metabolic phenomenon observed in cancer cells that is characterized by aerobic glycolysis instead of mitochondrial oxidative phosphorylation as the primary mechanism of cellular energy generation. The exact benefit...
Background/Objective: Enhanced recovery after surgery (ERAS) is a global surgical quality improvement initiative that aims to improve perioperative care based on evidence-based interventions. Although ERAS protocols in gastrointestinal (GI) surgery r...
Background/Objectives: Pancreatic metastases are uncommon and may resemble primary pancreatic neoplasms on imaging, making tissue confirmation essential. This study aimed to characterize pancreatic metastases diagnosed by endoscopic ultrasound-guided...
Pancreato-hepatobiliary (HPB) malignancies—pancreatic ductal adenocarcinoma (PDAC), hepatocellular carcinoma (HCC), and the biliary tract cancers (BTC) comprising intrahepatic, perihilar and distal cholangiocarcinoma, gallbladder carcinoma, and...
Background: Gastrointestinal (GI) involvement is increasingly recognised in paediatric SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C), but severe GI bleeding remains rare. Its pathogenesis in this setting is multifacto...
Background/Objectives: Although the exact etiology of Inflammatory Bowel Diseases (IBD) is not yet fully understood, recent evidence suggests that both genetic and dietary factors are involved in their pathogenesis. The aim of the present exploratory...
Ulcerative colitis affects millions of people worldwide, and acute severe ulcerative colitis (ASUC) remains one of its most urgent presentations because delayed recognition of steroid non-response can expose patients to colectomy, postoperative compl...
Background: The intake of mineral water for therapeutic purposes (crenotherapy) in digestive system disorders is a long-established practice, but there are still few controlled clinical studies confirming the effects of natural mineral water rich in...
Background and Objectives: This study aimed to characterize physicians’ knowledge and practice patterns regarding the use of probiotics in the management of irritable bowel syndrome (IBS). By examining clinical experiences and barriers to adopt...
Hepatobiliary disorders during pregnancy represent a significant cause of maternal and fetal morbidity, requiring careful differentiation between physiological adaptations of pregnancy and true hepatic pathology. This narrative review provides a comp...
Introduction: Gastrointestinal bleeding (GIB) is a potentially life-threatening condition associated with significant morbidity, mortality, and healthcare burden. While endoscopy remains the first-line method of management, transarterial embolization...
Background: Irritable bowel syndrome (IBS) is a chronic disorder of brain–gut interaction closely linked to psychological stress and highly prevalent among university student populations, yet data from Bahrain remain scarce. This study estimate...
Background: Colorectal cancer (CRC) remains a significant global health challenge, particularly because of its associated complications. Among these, tumor perforation is a critical event linked to increased postoperative morbidity and mortality. Thi...
Background: Clostridioides difficile infection (CDI) remains a leading cause of hospital-acquired infection. Metabolic-dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and has been associa...
Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal malignancy. The identification and management of precursor lesions, particularly the increasingly common intraductal papillary mucinous neoplasms (IPMNs), pose a significant challenge, c...
Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) is an emerging intervention that provides a minimally invasive approach to drainage of the gallbladder, showing promising results in treating acute cholecystitis (AC) and malignant biliary o...
Background/Objectives: The global adoption of minimally invasive surgery has generated extensive video repositories, creating new opportunities for data-driven surgical education and quality assessment. Automated surgical phase recognition enables ob...
Background/Objectives: Hepatocellular carcinoma (HCC) is the sixth most diagnosed cancer worldwide and a leading cause of cancer-related mortality. The majority of cases arise in the setting of chronic liver disease, where immune checkpoint inhibitor...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of global chronic liver disease, with a prevalence of approximately 30%. This review outlines the diagnostic transition from the exclusionary non-alcoholic fatty li...
Crohn’s disease (CD) is a chronic immune-mediated inflammatory disorder characterized by transmural inflammation and a progressive course that frequently leads to structural complications such as intestinal fibrosis. Fibrostenosing disease repr...
Background: Historically, diverticulosis and its complications emerged with the industrial revolution and subsequent socioeconomic changes, including dietary, which went from an agrarian high-fiber to a low-fiber, processed food product. Corporeal bo...
Background: The distance and angle between the superior mesenteric artery (SMA) and abdominal aorta play a role in the etiology of SMA syndrome. Retroperitoneal fat has been reported to affect both the distance and angle. Very few studies have report...
Objectives: To investigate the predictive value of the peripheral blood neutrophil percentage and serum albumin ratio (NPAR) for overall survival after radical resection of hepatocellular carcinoma, and to construct a nomogram prediction model. Metho...
Gastric neuroendocrine tumors (NETs) are increasingly diagnosed as incidental findings during upper gastrointestinal endoscopy. For the gastroenterologist, the crucial challenge is not only at the time of endoscopic recognition but also when the path...
Colonoscopy is the gold standard for diagnosing and monitoring gastrointestinal diseases. However, bowel preparation, rather than the procedure itself, appears to be the main driver of transient gut microbiota disruption. Available evidence suggests...
Background/Objectives: Non-steroidal anti-inflammatory drug (NSAID)-induced small bowel (SB) injuries have a variable clinical and endoscopic presentation. Limited data exists regarding their long-term outcomes, natural course, and discerning factors...
Introduction: Clostridioides difficile (C. difficile) is a major cause of antibiotic-associated diarrhea and healthcare-associated infections, with rising global incidence and severity due to the emergence of hypervirulent strains. Methods: This revi...
Objectives: This study aimed to investigate the impact of TDs on the survival of patients with locally advanced rectal cancer (LARC). Additionally, we propose a novel staging method that combines TDs and lymph node metastases (LNMs) to enhance progno...
Aims/Purpose: In case of superficial neoplastic GI lesions the depth of infiltration is associated with the risk of nodal metastasis and guides the choice between minimally invasive endoscopic treatments and resective surgery. The aim of the study wa...
Background/Objectives: The study aimed to determine the demographic and clinical characteristics of patients with acute variceal bleeding and identify predictive factors associated with treatment outcomes. Methods: The retrospective study included 91...
Background: Fecal calprotectin (FC) is a well-established, non-invasive biomarker of intestinal inflammation and is widely used to differentiate inflammatory bowel disease (IBD) from functional gastrointestinal disorders. Although enzyme-linked immun...
Immunotherapy with immune checkpoint inhibitors (ICIs) has represented a major breakthrough in the treatment of multiple solid and hematological malignancies, significantly improving survival and tumor control. However, the blockade of immune regulat...
Background/Objectives: Gastrointestinal (GI) manifestations may persist in COVID-19 survivors, potentially worsening pre-existing conditions and increasing the risk of malnutrition. Understanding the long-term association between GI symptoms and nutr...
Background: Most of the public hospitals in Hong Kong provide a regular colorectal endoscopic submucosal dissection (ESD) service. The current retrospective study aims to review the long- and short-term outcomes of these services, so as to identify a...
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its inflammatory subtype metabolic dysfunction-associated steatohepatitis (MASH) are now the most common types of chronic liver disease worldwide and major contributors to cirrhosis...
Background/Objectives: Autoimmune hepatitis (AIH) often coexists with extrahepatic autoimmune diseases (EADs); however, the clinical significance of EAD comorbidity and its subtypes remains incompletely understood. In addition, an increasing proporti...
Background: Helicobacter pylori infection is recognized as a Group I carcinogen and a primary driver of the gastric precancerous cascade. Andean populations in Peru experience disproportionately high rates of gastric cancer, yet data characteriz...
