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Enteropathogenic Escherichia coli—A Summary of the Literature

Department of Microbiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Târgu Mureș, Romania
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Academic Editor: Chien-Feng Li
Gastroenterol. Insights 2021, 12(1), 28-40; https://doi.org/10.3390/gastroent12010004
Received: 27 December 2020 / Revised: 15 January 2021 / Accepted: 25 January 2021 / Published: 27 January 2021
(This article belongs to the Section Gastrointestinal Disease)
Diarrheal disease is still a major public health concern, as it is still considered an important cause of death in children under five years of age. A few decades ago, the detection of enteropathogenic E. coli was made by detecting the O, H, and K antigens, mostly by agglutination. The recent protocols recommend the molecular methods for diagnosing EPEC, as they can distinguish between typical and atypical EPEC by identifying the presence/absence of specific virulence factors. EPEC are defined as diarrheagenic strains of E. coli that can produce attaching and effacing lesions on the intestinal epithelium while being incapable of producing Shiga toxins and heat-labile or heat-stable enterotoxins. The ability of these strains to produce attaching and effacing lesions enable them to cause localized lesions by attaching tightly to the surface of the intestinal epithelial cells, disrupting the surfaces of the cells, thus leading to the effacement of the microvilli. EPEC are classified on typical and atypical isolates, based on the presence or absence of E. coli adherence factor plasmids. All the EPEC strains are eae positive; typical EPEC strains are eae+, bfpA+, while atypical strains are eae+, bfpA−. No vaccines are currently available to prevent EPEC infections. View Full-Text
Keywords: diarrheal disease; typical/atypical enteropathogenic E. coli; virulence factors; diagnostic diarrheal disease; typical/atypical enteropathogenic E. coli; virulence factors; diagnostic
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MDPI and ACS Style

Mare, A.D.; Ciurea, C.N.; Man, A.; Tudor, B.; Moldovan, V.; Decean, L.; Toma, F. Enteropathogenic Escherichia coli—A Summary of the Literature. Gastroenterol. Insights 2021, 12, 28-40. https://doi.org/10.3390/gastroent12010004

AMA Style

Mare AD, Ciurea CN, Man A, Tudor B, Moldovan V, Decean L, Toma F. Enteropathogenic Escherichia coli—A Summary of the Literature. Gastroenterology Insights. 2021; 12(1):28-40. https://doi.org/10.3390/gastroent12010004

Chicago/Turabian Style

Mare, Anca D., Cristina N. Ciurea, Adrian Man, Bianca Tudor, Valeriu Moldovan, Luminița Decean, and Felicia Toma. 2021. "Enteropathogenic Escherichia coli—A Summary of the Literature" Gastroenterology Insights 12, no. 1: 28-40. https://doi.org/10.3390/gastroent12010004

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