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  • Review
  • Open Access
99 Citations
67,797 Views
126 Pages

28 September 2023

The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial d...

  • Article
  • Open Access
9 Citations
46,784 Views
10 Pages

14 March 2023

We have previously shown that pitavastatin has the potential to be used to treat ovarian cancer, although relatively high doses are likely to be necessary. One solution to this problem is to identify drugs that are synergistic with pitavastatin, ther...

  • Review
  • Open Access
10 Citations
32,070 Views
12 Pages

Use or Misuse of Albumin in Critical Ill Patients

  • Fuat Hakan Saner,
  • Bjoern-Ole Stueben,
  • Dieter Peter Hoyer,
  • Dieter Clemens Broering and
  • Dmitri Bezinover

28 April 2023

Since 1940 albumin has been used worldwide and is widely available commercially since this time. However, a meta-analysis in 1998 challenged the use of albumin and identified a trend toward higher mortality in critically ill patients who had received...

  • Article
  • Open Access
6 Citations
29,629 Views
14 Pages

13 October 2023

Background: Multiple trials have demonstrated the efficacy of fenofibrate for the management of dyslipidemia. Real-world evidence may provide important insights into the effectiveness and safety of fenofibrate in patients with metabolic syndrome and...

  • Review
  • Open Access
28 Citations
25,764 Views
24 Pages

Tuberculosis Diagnosis: Current, Ongoing, and Future Approaches

  • Guilherme Bartolomeu-Gonçalves,
  • Joyce Marinho de Souza,
  • Bruna Terci Fernandes,
  • Laís Fernanda Almeida Spoladori,
  • Guilherme Ferreira Correia,
  • Isabela Madeira de Castro,
  • Paulo Henrique Guilherme Borges,
  • Gislaine Silva-Rodrigues,
  • Eliandro Reis Tavares and
  • Sueli Fumie Yamada-Ogatta
  • + 3 authors

3 September 2024

Tuberculosis (TB) remains an impactful infectious disease, leading to millions of deaths every year. Mycobacterium tuberculosis causes the formation of granulomas, which will determine, through the host–pathogen relationship, if the infection w...

  • Article
  • Open Access
81 Citations
25,203 Views
26 Pages

Vitamin D and Calcium in Osteoporosis, and the Role of Bone Turnover Markers: A Narrative Review of Recent Data from RCTs

  • Gavriela Voulgaridou,
  • Sousana K. Papadopoulou,
  • Paraskevi Detopoulou,
  • Despoina Tsoumana,
  • Constantinos Giaginis,
  • Foivi S. Kondyli,
  • Evgenia Lymperaki and
  • Agathi Pritsa

8 February 2023

Osteoporosis is a common disease, defined primarily by a low measured bone density, which is associated with an increased risk of fragility fractures. Low calcium intake and vitamin D deficiency seem to be positively correlated with the prevalence of...

  • Review
  • Open Access
15 Citations
24,224 Views
20 Pages

Artificial Sweeteners: A Double-Edged Sword for Gut Microbiome

  • Helal F. Hetta,
  • Nizar Sirag,
  • Hassabelrasoul Elfadil,
  • Ayman Salama,
  • Sara F. Aljadrawi,
  • Amani J. Alfaifi,
  • Asma N. Alwabisi,
  • Bothinah M. AbuAlhasan,
  • Layan S. Alanazi and
  • Abdelazeem M. Algammal
  • + 3 authors

15 April 2025

Background and Aim: The human gut microbiome plays a crucial role in maintaining health. Artificial sweeteners, also known as non-nutritive sweeteners (NNS), have garnered attention for their potential to disrupt the balance of the gut microbiome. Th...

  • Systematic Review
  • Open Access
6 Citations
23,564 Views
18 Pages

The Impact of Vitamin D on Androgens and Anabolic Steroids among Adult Males: A Meta-Analytic Review

  • Ahmed Abu-Zaid,
  • Saleh A. K. Saleh,
  • Heba M. Adly,
  • Saeed Baradwan,
  • Abdullah M. Alharran,
  • Mshal Alhatm,
  • Mooza M. Alzayed,
  • Muteb N. Alotaibi,
  • Abdulbadih Rabih Saad and
  • Osama Alomar
  • + 2 authors

25 September 2024

Background: Recent studies indicate that vitamin D impacts male reproductive function, with deficiency linked to infertility. This review evaluates the effect of vitamin D supplementation on male fertility, focusing on total testosterone, free testos...

  • Review
  • Open Access
30 Citations
22,009 Views
21 Pages

Neurobiological Implications of Chronic Stress and Metabolic Dysregulation in Inflammatory Bowel Diseases

  • Aleksandar Sic,
  • Kiana Cvetkovic,
  • Eshanika Manchanda and
  • Nebojsa Nick Knezevic

18 September 2024

Chronic stress is a significant factor affecting modern society, with profound implications for both physical and mental health. Central to the stress response is cortisol, a glucocorticoid hormone produced by the adrenal glands. While cortisol relea...

  • Review
  • Open Access
5 Citations
21,090 Views
12 Pages

Lipschütz Ulcer and SARS-CoV-2: What We Currently Know?

  • Lucia Merlino,
  • Agnese Immacolata Volpicelli,
  • Mattia Dominoni,
  • Marianna Francesca Pasquali,
  • Giulia D’Ovidio,
  • Barbara Gardella and
  • Roberto Senatori

12 September 2023

Background: In recent years, several interesting case reports have been published which describe the possible role of SARS-CoV-2 infection or vaccination in the etiopathogenesis of Lipschütz ulcer. Our aim is to analyze this association and prov...

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Diseases - ISSN 2079-9721