Next Article in Journal
Inhibitory Effect of Ionizing Radiation on Echinococcus granulosus Hydatid Cyst
Next Article in Special Issue
Factors Influencing Quality of Life in Breast Cancer Patients Six Months after the Completion of Chemotherapy
Previous Article in Journal
Impact of Gut Dysbiosis on Neurohormonal Pathways in Chronic Kidney Disease
Previous Article in Special Issue
Assessing Gait in Parkinson’s Disease Using Wearable Motion Sensors: A Systematic Review

Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses

Department of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, Japan
Author to whom correspondence should be addressed.
Diseases 2019, 7(1), 22;
Received: 25 January 2019 / Revised: 10 February 2019 / Accepted: 11 February 2019 / Published: 13 February 2019
(This article belongs to the Special Issue Neuro-psychiatric Disorders - from Diagnosis to Care)
Psychiatric illnesses may be qualified to the cellular impairments of the function for survival or death in neurons, which may consequently appear as abnormalities in the neuroplasticity. The molecular mechanism has not been well understood, however, it seems that PI3K, AKT, GSK3, and their downstream molecules have crucial roles in the pathogenesis. Through transducing cell surviving signal, the PI3K/AKT/GSK3 pathway may organize an intracellular central network for the action of the synaptic neuroplasticity. In addition, the pathways may also regulate cell proliferation, cell migration, and apoptosis. Several lines of evidence have supported a role for this signaling network underlying the development and treatment for psychiatric illnesses. Indeed, the discovery of molecular biochemical phenotypes would represent a breakthrough in the research for effective treatment. In this review, we summarize advances on the involvement of the PI3K/AKT/GSK3 pathways in cell signaling of neuronal cells. This study may provide novel insights on the mechanism of mental disorder involved in psychiatric illnesses and would open future opportunity for contributions suggesting new targets for diagnostic and/or therapeutic procedures. View Full-Text
Keywords: PI3K; AKT; GSK3; PTEN; cell signaling; schizophrenia; depression PI3K; AKT; GSK3; PTEN; cell signaling; schizophrenia; depression
Show Figures

Figure 1

MDPI and ACS Style

Matsuda, S.; Ikeda, Y.; Murakami, M.; Nakagawa, Y.; Tsuji, A.; Kitagishi, Y. Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses. Diseases 2019, 7, 22.

AMA Style

Matsuda S, Ikeda Y, Murakami M, Nakagawa Y, Tsuji A, Kitagishi Y. Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses. Diseases. 2019; 7(1):22.

Chicago/Turabian Style

Matsuda, Satoru, Yuka Ikeda, Mutsumi Murakami, Yukie Nakagawa, Ai Tsuji, and Yasuko Kitagishi. 2019. "Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses" Diseases 7, no. 1: 22.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop