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Intercalated Cells: More than pH Regulation

Membrane Protein Research Group, Department of Physiology, Room 734, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
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These authors contributed equally to this work.
Diseases 2014, 2(2), 71-92; https://doi.org/10.3390/diseases2020071
Received: 22 January 2014 / Revised: 19 March 2014 / Accepted: 20 March 2014 / Published: 8 April 2014
(This article belongs to the Special Issue Feature Papers)
The renal collecting duct is the nephron segment where the final urine content of acid equivalents and inorganic ions are determined. The role of two different cell types present in this nephron segment has been determined many years ago: principal cells that express the epithelial sodium channel ENaC and aquaporin 2, regulate electrolyte reabsorption, while intercalated cells, which express acid-base transporters and vacuolar H+-ATPase, maintain an apropriate acid-base balance. Recent evidence challenges this historical view. Rather than having independent and non-overlapping functions, the two cell types in the collecting duct appear to functionally cooperate to regulate acid-base and volume homeostasis via complex paracrine and endocrine interplay. This review summarizes these recent findings. View Full-Text
Keywords: ercalated cells; principal cells; acid-base homeostasis; collecting duct; volume homeostasis; acid-base transporters; sodium; chloride; hypertension ercalated cells; principal cells; acid-base homeostasis; collecting duct; volume homeostasis; acid-base transporters; sodium; chloride; hypertension
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Almomani, E.Y.; Kaur, S.; Alexander, R.T.; Cordat, E. Intercalated Cells: More than pH Regulation. Diseases 2014, 2, 71-92.

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