Background: Whole-blood transcriptomics can characterize systemic responses to childhood infectious diarrhea, but exploratory regulatory predictions and candidate genes require independent assessment. Methods: We first reanalyzed pediatric whole-bloo...
Acute intestinal infections remain one of the leading causes of morbidity among children under five years of age and represent an important public health challenge in both developed and developing countries. Although these infections often share simi...
Background/Objectives: Unfavorable outcomes after locking plate fixation of geriatric proximal humerus fractures impair arm function and put social independence at risk. At short-/medium-term follow-up, comparable results have been demonstrated betwe...
Gastric neuroendocrine tumors (G-NETs) represent a heterogeneous group of neoplasms, traditionally classified into three types with distinct pathophysiological backgrounds, biological behavior, and prognosis. Endoscopic treatment plays a central role...
Background: Griscelli syndrome type 2 is a rare autosomal recessive disorder caused by pathogenic variants in the RAB27A gene, characterized by partial albinism, immunodeficiency, and a high risk of hemophagocytic lymphohistiocytosis (HLH). Case desc...
Background/Objectives: Programs combining resistance training with a concurrent cognitive demand are often presented as superior to resistance training alone, although the contribution of the cognitive component has never been quantified. This review...
Forced migration is an ongoing trajectory rather than a single event, with mental-health consequences shaped by changing legal, material, social and service conditions. Although established models connect post-migration stressors with psychological p...
Background/Objectives: Intestinal diseases constitute a significant global public health issue and encompass a broad spectrum of inflammatory, functional, and infectious disorders, including inflammatory bowel disease (Crohn’s disease and ulcer...
Background: Early initiation of high-efficacy treatment (HET) in patients with demyelinating central nervous system (CNS) diseases is associated with improved long-term prognosis. Identifying parameters linked to delayed HET initiation could facilita...
Background: An estimated 13.4 million infants were born preterm worldwide in 2020, highlighting the need for early identification of those at risk of adverse neonatal outcomes. Preterm infants constitute a heterogeneous population in terms of maturit...
Background: Tuberculosis (TB) has various clinical presentations. Pulmonary TB (PTB) affects only the lungs. In contrast, miliary TB (MTB) is a disseminated form of the disease, while pleural TB (PLTB) is a localized disease that affects the pleura....
Background: Non-Hodgkin lymphoma (NHL) involving the ear, nose, and throat (ENT) region comprises a heterogeneous group of nodal and extranodal lymphoid malignancies with distinct clinicopathological features. This review aimed to provide an integrat...
Background: Social isolation and loneliness are established social determinants of health, associated with 25–30% higher mortality risk, yet their relationship with systemic inflammation and broader biological and clinical outcomes has not been...
Background: Contemporary management of type 2 diabetes mellitus (T2DM) has shifted from a glucose-centered approach toward integrated cardio-renal–metabolic protection. Although sodium–glucose cotransporter-2 (SGLT2) inhibitors, glucagon-...
Introduction: Virological cure in chronic infection with hepatitis C virus (HCV) is followed by important clinical and biological benefits, including psychological ones. The White Bear Suppression Inventory (WBSI) assesses the tendency to suppress in...
Background: Tetanus is a vaccine-preventable disease that has become rare in countries with sustained immunization programs. However, unvaccinated children remain at risk of severe disease. We provide an epidemiological overview of tetanus in Serbia...
Background: Genotype-resolved data on human papillomavirus (HPV) are almost absent for Venezuelan indigenous women. Methods: We studied 260 women from La Guajira (Wayuu, n = 94), Maniapure (Eñepa, n = 141), and Delta Amacuro (Warao, n = 25), p...
Background. Diabetic kidney disease (DKD) can progress despite contemporary kidney-protective treatment, motivating the development of additional mechanism-based interventions. This critical narrative review evaluates whether gene-, RNA-, and cell-ba...
Multiple sclerosis (MS) has shifted in a generation from an uncommon diagnosis in Saudi Arabia to a major cause of neurological disability in young adults. Available Saudi data describe clinical characteristics broadly similar to those reported elsew...
Aim: To compare the frequency of cell damage at the division stage, apoptosis, and necrosis/nuclear destruction in the buccal epithelial cytogram of individuals with impaired carbohydrate metabolism. Materials and Methods: In this observational cross...
Background: Relapse remains a major clinical challenge in multiple myeloma (MM), highlighting the need to identify circulating proteins associated with relapse as candidates for disease monitoring and further biomarker development. Methods: An integr...
Background/Objectives: Diabetes-related renal, lipid, and hepatic abnormalities are clinically important, but their distribution may be heterogeneous and is not fully represented by HbA1c alone. We characterized the temporal age and sex composition o...
Background: Artificial intelligence (AI) is increasingly being integrated into insulin management through decision-support systems, adaptive bolus calculators, conversational platforms, and automated insulin delivery (AID) technologies. However, the...
Objective: To develop and comparatively evaluate machine learning models for predicting 1-year survival in hepatocellular carcinoma (HCC) patients, focusing on the prognostic interplay between chronic liver diseases and diabetes aligned with the EASL...
Hypertension is a major cardiovascular risk factor, but its epidemiology in people with multiple sclerosis (PwMS) remains unclear. Whether PwMS have a higher prevalence of hypertension than the general population, the potential pathways linking the t...
Background: Accurate scoring is essential when patient-reported self-management instruments are related to biochemical outcomes. The principal contribution of this study was to reconstruct and audit Diabetes Self-Management Questionnaire (DSMQ) score...
Background: Falls in older women are multifactorial events driven by the complex interaction of age-related loss of physiological reserve, frailty, sarcopenia, chronic low-grade inflammation, multimorbidity, and medication exposure. Older women repre...
Background/Objectives: Sexually transmitted infections (STIs) are resurgent globally, yet sub-national epidemiological data from Romania remain sparse. This study characterizes long-term STI trends in Galați County (population ~500,000) and exam...
Background: Adenosine kinase (ADK) and the ectonucleotidases CD39 and CD73 regulate adenosine metabolism and play important roles in the pathogenesis of liver diseases. Their involvement in metabolic dysfunction-associated steatotic liver diseas...
Background/Objectives: Controlled attenuation parameter (CAP) is widely used as a noninvasive marker of hepatic steatosis, but its prognostic significance in nonviral chronic liver disease is unclear. We evaluated the association of CAP with all-caus...
Background: Romania continues to experience one of the highest tuberculosis (TB) burdens in the European Union/European Economic Area. During the COVID-19 pandemic, reduced inpatient capacity accelerated the use of ambulatory care for patients with d...
Background/Objectives: Older patients make up a growing share of the lung-resection workload, and C-reactive protein measured in the first days after operation is used to judge recovery. Whether the same concentration means the same thing in older me...
Background: Mild cognitive impairment (MCI) is a transitional state between normal aging and dementia, and genetic factors may influence progression. This study aimed to identify genetic polymorphisms associated with MCI and dementia in a Russian pop...
Background/Objectives: We examined combinations of immune- and stromal-associated features in pretreatment triple-negative breast cancer (TNBC) biopsies and explored their clinical and germline associations. Methods: This retrospective study included...
Background/Objectives: Chronic whiplash-associated disorders (WAD) are a common cause of persistent neck pain and disability. Therapeutic exercise is widely used, but its effectiveness remains uncertain. This systematic review evaluated the effects o...
Background: Nasopharyngeal carcinoma (NPC) may be accompanied by systemic inflammatory changes, but routine inflammatory markers are nonspecific and have not been validated as diagnostic tests for NPC. Methods: This exploratory retrospective comparis...
Background/Objectives: Mental-health research often represents chronological age as a threshold or adjustment variable, although psychosocial associations may vary across adulthood. We tested whether continuous age modified the association between a...
Background and Objectives: Oral squamous cell carcinoma (OSCC) belongs to a broad group of malignant neoplasms of the head and neck. It is known that components of the tumor microenvironment (TME) influence tumor progression. Similar patterns are bei...
Objectives: Infectious complications, particularly those caused by multidrug-resistant organisms (MDROs), remain a major cause of morbidity and mortality after liver transplantation (LT). While pre-transplant colonization is a recognized risk factor,...
Background/Objectives: Acute appendicitis is readily recognised, but its initiating mechanisms remain uncertain. Viral findings are often interpreted without separating direct appendiceal infection, systemic host responses, clinical phenocopies, and...
Background/Objectives: Understanding the biological role of the receptor activator of nuclear factor-κB ligand (RANK), its ligand (RANKL), and the decoy receptor osteoprotegerin (OPG) is vital for clarifying the pathogenesis of gnathic giant ce...
Background/Objectives: Early-onset dementia (EOD), defined as symptom onset before 65 years of age, is a clinically and genetically heterogeneous group. Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are its most common neurodegener...
Background/Objectives: Systemic inflammatory indices may differ prognostically between resectable and palliative pancreatic cancer. We compared associations of the aggregate index of systemic inflammation (AISI), systemic inflammation response index...
Background/Objectives: Thyroid disorders may involve systemic oxidative and carbonyl disturbances, but compartment-specific changes in catalase activity and methylglyoxal concentration across different clinical phenotypes remain unclear. This study a...
Background/Objectives: Sleep disturbance is increasingly recognized as a key contributor to symptom burden and functioning in paediatric oncology, yet comparative evidence across clinical and healthy populations remains limited. This study examined s...
Background: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe, potentially life-threatening mucocutaneous reactions classified based on body surface area (BSA) involvement: SJS affects less than 10% BSA, SJS/TEN ove...
Background/Objectives: Immune checkpoint inhibitors have transformed oncology by inducing unexpected and sustained remissions in some patients; however, this atypical survival may be accompanied by significant psychosocial and existential challenges....
Background: The total urinary protein-to-creatinine ratio (PCr) measures proteinuria but does not establish tubular injury or its recovery. Methods: We examined PCr changes after switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafena...
Breast cancer (BC) exhibits considerable metastatic heterogeneity and distinct patterns of organotropism, which contribute to differences in patient outcomes and therapeutic responses. However, the molecular mechanisms underlying this organ specifici...
Background/Objectives: Severe acute pancreatitis accounts for 20% of acute pancreatitis episodes and carries a substantial mortality risk. The systematic severity of the disease is driven by a massive cytokine release, with Interleukin-17 (IL-17) act...
