Nanoparticle-Mediated Immunotherapy: Reshaping the Tumor Microenvironment for Enhanced Cancer Treatment
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Methods".
Deadline for manuscript submissions: 30 March 2026 | Viewed by 69
Special Issue Editor
Interests: lymphoma; immunology; oncology; drug delivery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The tumor microenvironment (TME) constitutes a significant obstacle to effective cancer treatment, characterized by conditions such as hypoxia, acidosis, elevated interstitial fluid pressure, and immunosuppressive factors. These conditions impede the delivery and efficacy of conventional therapies, thereby necessitating the development of innovative strategies. Nanomedicine, which involves the application of nanotechnology in medicine, offers a promising approach to addressing the complexities of the TME. Nanoparticles (NPs) can be engineered with distinct physicochemical properties, facilitating targeted drug delivery, enhanced therapeutic efficacy, and reduced systemic toxicity. However, the successful translation of NP-based therapies requires a comprehensive understanding of the interactions between NPs and the TME.
This Special Issue is dedicated to the latest advancements in nanomedicine strategies that effectively navigate the tumor microenvironment (TME) to enhance drug delivery and therapeutic outcomes in cancer treatment. The exploration of this topic is structured around three principal sub-categories: 1. Tumor-targeting approaches: These strategies employ nanoparticles to selectively deliver drugs to tumor cells by utilizing specific ligands or physical cues. 2. Local treatments: Nanomedicine platforms are engineered for intra- or peritumoral injection to achieve elevated local drug concentrations while minimizing systemic side effects. 3. Systemic immunotherapy approaches: This involves the use of nanoparticles to remodel the TME, counteract immunosuppression, and augment systemic immune responses. By examining these complex relationships and themes, this study aims to expedite the development of innovative nanomedicine platforms for cancer treatment.
Dr. Mohd Ahmar Rauf
Guest Editor
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Keywords
- tumor microenvironment
- drug delivery
- nanoparticle
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