Organelle Crosstalk: New Insights into Intracellular Communication and Dynamics
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 March 2026 | Viewed by 18
Special Issue Editor
Interests: intercellular crosstalk between tumoral cells and tissue-resident cells in both brain and lung metastasis using different models of tumoral dormancy, advanced imaging techniques, and spatial transcriptomics/proteomics
Special Issue Information
Dear Colleagues,
The classical view of organelles as isolated compartments has been fundamentally overturned. We now appreciate the eukaryotic cell as a complex, integrated system where organelles like the ER, mitochondria, Golgi, and lysosomes continuously communicate through membrane contact sites and vesicular trafficking. This intricate crosstalk is not merely a background process; it is a central regulatory mechanism that controls calcium signaling, lipid metabolism, proteostasis, and cell fate decisions. Disruptions in this delicate dialogue are increasingly linked to pathologies ranging from neurodegeneration to cancer and metabolic syndromes.
This Special Issue seeks to highlight the latest breakthroughs in understanding the mechanisms and functions of organelle communication. We are particularly interested in studies that employ innovative approaches, including high-resolution live-cell imaging and organelle-specific proteomics, as well as novel biosensors and computational models, to decode these intracellular conversations. We invite the submission of original research articles and insightful reviews that explore the dynamic interplay between organelles in health and disease. By bringing together diverse perspectives, we aim to foster a deeper understanding of cellular organization and identify novel therapeutic targets.
Dr. Jonathan Barra
Guest Editor
Manuscript Submission Information
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Keywords
- organelle contact sites
- membrane contact sites
- intracellular communication
- early endosomes
- recycling endosomes
- Golgi
- mitochondrial dynamics
- ER stress
- mitophagy
- autophagy
- lysosome
- calcium signaling
- lipid transfer
- proteostasis
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