From Development to Degeneration: Advances in Stem Cell and Organoid Models of the Nervous System
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 100
Special Issue Editor
Interests: brain organoids; in vitro models; gut–brain axis; bioactive molecules; neuroendocrine control; inflammation; oxidative stress; microbiota; nanoparticles; sustainable biomolecules
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The rising prevalence of neurodegenerative and neurodevelopmental disorders poses a significant public health challenge, requiring innovative research strategies. These conditions involve progressive alterations in specific neural circuits, leading to debilitating symptoms and a decline in quality of life. The exact causes remain largely unknown, with genetic, environmental, and lifestyle factors all contributing to their development. Despite advances in understanding the underlying molecular mechanisms, effective treatments are limited, partly due to the lack of cellular models that accurately replicate the physiological and pathological aspects of these diseases. Furthermore, differences between the human central nervous system and laboratory animal models complicate therapeutic development.
In this scenario, stem cells and brain organoids offer a promising approach to research and therapy. Induced pluripotent stem cells (iPSCs) can be derived from patients, providing a unique platform for in vitro modeling. Brain organoids created from iPSCs simulate the human brain’s architecture and functions, enabling deeper insights into neural development as well as disease mechanisms.
This Special Issue aims to highlight recent advancements in stem cell and organoid research, emphasizing their potential to revolutionize our understanding of neurodevelopment and neurodegeneration and to advance the development of targeted, personalized treatments.
You may choose our Joint Special Issue in Organoids.
Dr. Elena Coccia
Guest Editor
Manuscript Submission Information
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Keywords
- neurodevelopment
- neurodegeneration
- stem cells
- brain organoids
- disease modeling
- therapeutic strategies
- personalized medicine
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