Cellular and Molecular Mechanisms of Cell Death in Neurodegenerative Diseases
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 15 April 2026 | Viewed by 5
Special Issue Editors
Interests: CRISPR genetic screens; iPSC derived models; single-cell genomics; gene regulation; RNA biology; neurodegeneration; cell biology; neurobiology
Interests: neurodegeneration; cellular programming; CRISPR genetic screens; iPSC-derived models
Special Issue Information
Dear Colleagues,
Loss of neuronal tissue is a hallmark of neurodegenerative disease pathology and a central driver of their progression. Consequently, elucidating the mechanisms of cell death is critical to understanding these neurological disorders. In addition to intrinsic neuronal stressors, such as protein aggregates and metabolic defects, dysregulated glial cells can contribute to neurodegeneration by releasing pro-inflammatory cytokines and failing to provide essential neuroprotective support, further amplifying neuronal loss. Understanding the initiators and mediators of cell death is essential not only for curbing disease progression but also for unraveling the homeostatic processes that underlie neuronal dysfunction and neuroinflammation.
This Special Issue will focus on both intrinsic and extrinsic mechanisms of cell death in the nervous system. We aim to showcase advances and current insights into the pathways driving cell death in neurodegenerative conditions, along with emerging technologies that facilitate their investigation. We welcome submissions of original research and review articles that explore experimental models and molecular mechanisms related to neuronal and glial cell death in neurodegenerative diseases.
Dr. Nikolaos Patikas
Dr. Emmanouil Metzakopian
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cell death
- neurodegenerative diseases
- molecular biology
- genomics
- neuroinflammation
- protein aggregation
- neurobiology
- mitochondria dysfunction
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