Autoimmune Diseases: Immune Cells and Genetic and Epigenetic Regulations
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 1054
Special Issue Editor
Interests: immune tolerance; autoimmunity; epigenetics; B lymphocytes; innate immunity; biotherapeutics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autoimmune diseases represent a complex group of disorders characterized by the immune system mistakenly attacking the body’s own tissues. These conditions can affect nearly any organ or tissue, leading to chronic inflammation, tissue damage, and varying degrees of functional impairment. Understanding autoimmune diseases requires insight into the intricate interplay between immune cells and genetic and epigenetic regulations that govern immune tolerance and activation. Deciphering the mechanisms behind autoimmunity is vital for developing targeted therapies that can restore immune tolerance and reduce inflammation, ultimately improving outcomes for patients affected by these chronic and often debilitating disorders.
This Special Issue will focus on the mechanisms underlying the disruption of immune tolerance in autoimmune diseases and recent approaches aiming to design novel therapeutic strategies for this group of disorders.
Genes determining susceptibility to autoimmune diseases and their variants will be considered. The role of immune cells, including T Lymphocytes, B Lymphocytes, antigen-presenting cells, natural killer cells, and innate lymphoid cells, will be discussed.
Epigenetic modifications, such as DNA methylation, histone modification, and non-coding RNAs, and environmental factors that can induce epigenetic changes, potentially triggering autoimmunity in genetically predisposed individuals, will also be discussed.
Factual and review-type articles are welcome.
Dr. Moncef M. Zouali
Guest Editor
Manuscript Submission Information
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Keywords
- autoimmune diseases
- immune cells
- lymphocytes
- antigen-presenting cells
- natural killer cells
- innate lymphoid cells
- epigenetic modifications
- autoimmunity
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