Mitochondrial Dysfunction in Neurodegeneration and Aging
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Mitochondria".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 114
Editor
Interests: neuronal mitochondrial biology; neurodegeneration; melatonin signaling; oxidative stress; neuroinflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria are central regulators of cellular metabolism, energy production, and stress response, making them particularly critical for the maintenance of neuronal health. Neurons, with their high energetic demands and limited regenerative capacity, are especially vulnerable to mitochondrial perturbations. Accumulating evidence has identified mitochondrial dysfunction as a unifying hallmark of aging and a major driver of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.
This Special Issue aims to highlight the recent advances in our understanding of the molecular mechanisms linking mitochondrial dysfunction to neuronal decline and aging. Key areas of focus include alterations in oxidative phosphorylation, mitochondrial dynamics, mitophagy, calcium homeostasis, and reactive oxygen species signaling. Emerging studies also underscore the importance of mitochondrial–nuclear communication and epitranscriptomic regulation in shaping mitochondrial function under physiological and pathological conditions. By bringing together original research articles and comprehensive reviews, this Special Issue seeks to provide new insights into how mitochondrial dysfunction contributes to neurodegeneration and aging while also identifying novel therapeutic strategies aimed at restoring mitochondrial homeostasis and enhancing cellular resilience.
Dr. Abhishek Jauhari
Guest Editor
Manuscript Submission Information
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Keywords
- mitochondrial dysfunction
- neurodegeneration
- aging
- mitophagy
- oxidative stress
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