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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Cellular and Molecular Basis of Lifestyle Factors in Cancer Progression and Prevention

edited by Vivek Kumar Kashyap and Himanshu Narayan Singh

submission deadline 30 Sep 2026 | 1 articles | Viewed by 4946 | Submission Open

Keywords: lifestyle factors; smoking; alcohol consumption; cancer risk; cancer prevention recommendations; modifiable risk factors

(This special issue belongs to the Section Cellular Pathology)

Molecular and Cellular Drivers of Parkinson's Disease

edited by

Fatema Currim

and

Jason Cannon

submission deadline 30 Sep 2026 | 3 articles | Viewed by 3794 | Submission Open

Keywords: Parkinson’s disease; neurodegeneration; mitochondrial dysfunction; α-synuclein aggregation; neurotoxicity; neuroinflammation; oxidative stress; environmental factors; gene–environment interactions; cell death

(This special issue belongs to the Section Cellular Neuroscience)

Pediatric Liver Tumors: Molecular Mechanisms and Therapeutic Strategies

edited by

Edward V. Prochownik

submission deadline 30 Sep 2026 | 3 articles | Viewed by 3368 | Submission Open

Keywords: hepatoblastoma; hepatocellular carcinoma; pediatric liver tumors; fibrolamellar carcinoma; Beck-with-Wiedmann syndrome; hereditary tyrosinemia; molecular mechanisms; therapeutic strategies

Cellular and Molecular Insights into Gynecologic Tumors

edited by

Mladen Anđić

and

Jianjun Wei

submission deadline 30 Sep 2026 | 3 articles | Viewed by 3268 | Submission Open

Keywords: gynecologic cancers; cervical cancer; endometrial cancer; ovarian tumors; tumor microenvironment; molecular biomarkers; genetic mutations; targeted therapies

The Role of Light in Ocular Health and Disease

edited by Krisztina Valter,

María Ana Contín

and

Monica Acosta

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3223 | Submission Open

Keywords: light; photobiology; light exposure; circadian rhythms; vision; light-induced retinal damage; phototoxicity; photoprotection; retinal degeneration; light modulation; oxidative stress; light therapy; photobiomodulation; blue light effects; Protective wavelengths; harmful wavelengths; ocular phototransduction; light-based therapeutics

Stress Signaling and Cell Fate Determination: The Role of Mitochondria

edited by

Daniel Maddison

and

Bilal Malik

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3016 | Submission Open

Keywords: mitochondria; cell death; integrated stress response; retrograde signaling; apoptosis; necroptosis; ferroptosis; mitophagy; mitochondrial dynamics; ROS; calcium signaling; inter-organelle communication

Brain Organoids for Disease Modeling

edited by

Jonghun Kim

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2229 | Submission Open

Keywords: brain organoids; induced pluripotent stem cells (iPSCs); neurodevelopmental disorders; neurodegenerative diseases; neuronal activity; organoid-based drug screening

(This special issue belongs to the Section Stem Cells)

Cellular and Molecular Mechanisms of Alcohol-Induced Cellular/Organ Injury and Regeneration

edited by Mukund Srinivasan

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2056 | Submission Open

Keywords: alcohol use disorder; ethanol; liver; lung; pancreas; gut; brain; cellular toxicity; alcohol metabolism; alcohol metabolites; oxidative stress; mitochondrial stress; ER stress

Cell Signaling of Cancer Therapy

edited by

Anna Boguszewska-Czubara

and Anna Wawruszak

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1649 | Submission Open

Keywords: cell signaling; cancer therapy; signal transduction; targeted therapy; gene therapy; RNA-based therapeutics; drug resistance; tumor microenvironment; precision oncology

(This special issue belongs to the Section Cell Signaling)

Role of Endothelial Progenitor Cells in Vascular Dysfunction

edited by

Catherine Yzydorczyk

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1383 | Submission Open

Keywords: cardiovascular diseases; endothelial progenitor cells; vasculogenesis; angiogenesis; inflammation; oxidative stress; cellular senescence; developmental programming; cellular therapy

Neural Governance of Gastrointestinal Motility

edited by Jiande Chen

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1302 | Submission Open

Keywords: enteric nervous system; gastrointestinal motility; neural circuitry; neurotransmitter signaling; smooth muscle regulation; neuron–epithelial; organoid models; gut-brain axis; neuro-immune interaction; neuromodulation

State of the Art in Tumor Immunotherapy: From Cell Biology to Therapeutic Perspectives

edited by

Cristabelle De Souza

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1103 | Submission Open

Keywords: T-cell exhaustion; immune checkpoint blockade (PD-1/PD-L1); CAR-T cell engineering; tumor microenvironment (TME); antigen presentation machinery; TCR signaling; myeloid-derived suppressor cells (MDSCs); cancer immunoediting; immunogenic cell death; adoptive cell transfer

(This special issue belongs to the Section Cellular Immunology)

Novel Insights into Endothelial Cells in Vascular Disease

edited by

LI Zhang

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1067 | Submission Open

Keywords: endothelial cells; vascular diseases; vascular signaling

Ubiquitin Ligases in Health and Diseases

edited by Haitao Luan

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1010 | Submission Open

Keywords: ubiquitination; E3 ubiquitin ligase; Proteasome; protein degradation; cell cycle regulation; immune response; neurodegeneration; cancer; autoimmune disorders; therapeutic targeting

(This special issue belongs to the Section Cell Signaling)

New Tools to Address Old Challenges in Tolerogenic Cellular Therapies

edited by Konstantinos Mengrelis and

Nina Pilat

submission deadline 30 Sep 2026 | 1 articles | Viewed by 945 | Submission Open

Keywords: tolerogenic strategies; immune tolerance; allogeneic cellular therapies; autoimmunity; allergy; systems immunology; artificial intelligence; biomarkers; immune regulation

Aging, Oxidative Stress, and Inflammation in Ocular Diseases

edited by

Bhavana Chhunchha

submission deadline 30 Sep 2026 | 1 articles | Viewed by 891 | Submission Open

Keywords: aging; oxidative stress; inflammation; ocular diseases

Interleukin-1 Signaling in Cancer: Novel Mechanisms and Therapeutic Opportunities

edited by Afshan Fathima Nawas and

Jaehong Kim

submission deadline 30 Sep 2026 | 1 articles | Viewed by 785 | Submission Open

Keywords: interleukin-1 signaling; tumor microenvironment; inflammatory pathways; cytokine networks; cancer cell proliferation; epigenetic regulation in cancer; non-coding RNAs; immune modulation; cancer metabolism

Stem Cells, Disease Mechanisms, and Therapeutic Innovations in Breast and Endometrial Disorders

edited by

Walid Shaalan

, Benedikt Schaefgen and

Nourhan Hassan

submission deadline 30 Sep 2026 | Viewed by 668 | Submission Open

Keywords: endometrial stem cells; breast cancer; endometrial diseases; tumor microenvironment; matrix remodeling; regenerative medicine; bioengineering; stem cell therapy; molecular pathogenesis; disease modeling

(This special issue belongs to the Section Stem Cells)

Noncoding RNAs: Immunity, Mechanisms, and Biomarker Potential

edited by

Md Mahfuzur Rahman

submission deadline 30 Sep 2026 | 1 articles | Viewed by 604 | Submission Open

Keywords: noncoding RNAs (ncRNAs); MicroRNAs (miRNAs); long noncoding RNAs (lncRNAs); circular RNAs (circRNAs); immune regulation; tumor microenvironment; immune checkpoints; cancer immunotherapy; liquid biopsy biomarkers; immune evasion

Heat Shock Proteins and Human Cancers—2nd Edition

edited by

Alexander Kabakov

submission deadline 30 Sep 2026 | Viewed by 413 | Submission Open

Keywords: heat shock protein; glucose-regulated protein; cancer; tumorigenesis; theranostics; anticancer vaccine

Exploring New Treatments: Innovative Strategies Based on the Mechanism and Pathogenesis of Neurodevelopmental Disorders

edited by

Muhammad Nauman Arshad

and

Bruce Carter

submission deadline 30 Sep 2026 | Viewed by 407 | Submission Open

Keywords: rett syndrome; fragile X; GABA; seizures; cognition; Cdkl5 deficiency disorder; motor deficits; developmental delay

Multi-Omics Technologies in Immunity Within Tumors

edited by

Muhammad A. Alsherbiny

and

Anas M. Abdel Rahman

submission deadline 30 Sep 2026 | Viewed by 398 | Submission Open

Keywords: multi-omics; proteomics; metabolomics; lipidomics; genomics and epigenomics; synergistic combinations for cancer; AI applications in multi-omics integrations; tumor microenvironment (TME); cancer immunotherapy; immuno-oncology; integrative analysis of multi-omics; biomarkers; precision medicine; tumor heterogeneity

Paradigm-Challenging Research and Out-of-the-Box (OB) Hypotheses

edited by

Orna Elroy-Stein

and

Cord Brakebusch

submission deadline 30 Sep 2026 | Viewed by 384 | Submission Open

Astrocytes: Roles and Functions in the Brain

edited by

Victor Huang

and

Rita Raisman-Vozari

submission deadline 30 Sep 2026 | Viewed by 373 | Submission Open

Keywords: astrocyte biology; glial cells; synaptic regulation; CNS disorders; neuroinflammation; blood–brain barrier; brain metabolism; reactive astrocytes; neuron–glia interaction; therapeutic targeting

Oral Disease: Cellular Mechanisms and Emerging Therapeutic Strategies

edited by

Rucha Arun Bapat

and Marziyeh Aghazadeh

submission deadline 30 Sep 2026 | Viewed by 349 | Submission Open

Keywords: oral diseases; amelogenesis; dentinogenesis; periodontitis; dental fluorosis; oral manifestations of systemic diseases; oral squamous cell carcinoma; leukoplakia; erythroplakia

(This special issue belongs to the Section Cellular Pathology)

Sickle Cell Disease: Pathogenesis and Therapies

edited by

Laure Joseph

and Geoffrey Cheminet

submission deadline 30 Sep 2026 | Viewed by 346 | Submission Open

Keywords: sickle cell disease; erythrocyte sickling; chronic inflammation; endothelial dysfunction; hematopoietic stem cell transplantation

(This special issue belongs to the Section Cellular Pathology)

mRNA Regulation in Endoplasmic Reticulum Stress and Protein Homeostasis

edited by

Jagadeesh Uppala

Saeid Ghavami

and

Gerardo Z. Lederkremer

submission deadline 30 Sep 2026 | Viewed by 306 | Submission Open

Keywords: mRNA; secondary structures of mRNA; upstream open reading frames (uORFs); biomarkers; endoplasmic reticulum stress; unfolded protein response; protein homeostasis

(This special issue belongs to the Section Cell and Gene Therapy)

Advances in Cardiometabolic Pathophysiology and Treatment

edited by

Paolo Magni

and

Carla Perego

submission deadline 30 Sep 2026 | Viewed by 293 | Submission Open

Keywords: insulin resistance; immunometabolism; low-grade chronic inflammation; cardiovascular diseases; obesity; type 2 diabetes mellitus; adipose/adipocyte dysfunction; dyslipidemia; atherosclerosis; metabolic-associated steatotic liver disease

(This special issue belongs to the Section Cellular Metabolism)

Molecular Mechanisms and Biomarker Development in Prostate Cancer

edited by Vikas Mehta and Behtash Ghazi Nezami

submission deadline 30 Sep 2026 | Viewed by 279 | Submission Open

Keywords: androgen receptor; prostate molecular alterations; biomarkers

Immune Cell Signaling Networks: Receptors, Second Messengers and Gene Programs

edited by

Nima Gharahdaghi

submission deadline 30 Sep 2026 | Viewed by 277 | Submission Open

Keywords: immune signaling; receptor signaling; cytokine receptors; immune cells; infectious disease

(This special issue belongs to the Section Cell Signaling)

Applications of Organ-on-a-Chip Model in Vascular Disease

edited by Abidemi Junaid and Netanel Korin

submission deadline 30 Sep 2026 | Viewed by 272 | Submission Open

Keywords: organ‑on‑a‑chip; microfluidics; vascular disease; endothelial dysfunction; hemodynamics and shear stress; thrombosis and inflammation; drug screening; precision medicine

(This special issue belongs to the Section Cells of the Cardiovascular System)

Organelle-Driven Oncogenic Programs: Regulation, Cross-Talk and Targetable Vulnerabilities

edited by Tejinder Pal Khaket

submission deadline 30 Sep 2026 | Viewed by 226 | Submission Open

Keywords: organelle cross-talk; mitochondrial signaling; ER stress and unfolded protein response (UPR); lysosomal function and autophagy; metabolic reprogramming; redox homeostasis and oxidative stress; organelle stress responses; multi-omics and spatial biology; therapeutic vulnerabilities in cancer; organelle-targeted therapies

(This special issue belongs to the Section Cellular Pathology)

Molecular and Cellular Advances in Understanding Early Embryo Development—3rd Edition

edited by

Lon J. van Winkle

submission deadline 30 Sep 2026 | Viewed by 225 | Submission Open

Keywords: metabolism; biomembrane transport; genetics; epigenetic modifications; transgenerational inheritance; signaling; ART; in vitro culture; trophectoderm; inner cell mass

(This special issue belongs to the Section Reproductive Cells and Development)

Pathogenesis and Therapies of Chronic Obstructive Lung Diseases

edited by

Neeraj Vij

submission deadline 30 Sep 2026 | Viewed by 223 | Submission Open

Keywords: chronic obstructive pulmonary disease; COPD; asthma; airway inflammation; lung remodeling; oxidative stress; animal models; epithelial dysfunction; therapeutic targeting

(This special issue belongs to the Section Cellular Pathology)

AMPK Signaling Networks in Cellular Energy Metabolism

edited by William Smiles

submission deadline 30 Sep 2026 | Viewed by 211 | Submission Open

Keywords: metabolism; phosphorylation; cancer; type 2 diabetes; signaling; exercise; skeletal muscle; mTOR

(This special issue belongs to the Section Cell Signaling)

Neuron–Glia Synergy and Dysfunction in Parkinson’s Disease

edited by

Fábio Teixeira

submission deadline 30 Sep 2026 | Viewed by 210 | Submission Open

Keywords: Parkinson’s disease; neuron–glia interactions; neuroinflammation; glial cells dysfunction

(This special issue belongs to the Section Cellular Neuroscience)

How the DNA Damage Response Modifies Transcription Regulators

edited by Norbert Lehming

submission deadline 30 Sep 2026 | Viewed by 210 | Submission Open

Keywords: DNA damage; chromatin; gene expression; conditional mRNA degradation; DNA repair; cancer; apoptosis

DNA Damage in Neurodegeneration

edited by

Francesca Esposito

and Sofia Francia

submission deadline 30 Sep 2026 | Viewed by 193 | Submission Open

Keywords: DNA damage; neurodegeneration; DNA repair; oxidative stress; genomic instability; neuronal cell death; aging; animal models; cellular senescence

(This special issue belongs to the Section Cellular Neuroscience)

Immunological Study of Islet Transplantation

edited by Wanxing Cui

submission deadline 30 Sep 2026 | Viewed by 190 | Submission Open

Keywords: islet transplantation; transplant immunology; immune rejection; immune tolerance; regulatory T cells; autoimmunity; islet encapsulation; islet preservation; cGMP cell processing; type 1 diabetes

(This special issue belongs to the Section Cellular Immunology)

Cellular and Molecular Mechanisms of Obstructive Sleep Apnea

edited by Jivan Lamichhane, Abhishek Thakur and

Matiram Pun

submission deadline 30 Sep 2026 | Viewed by 185 | Submission Open

Keywords: sleep; sleep apnea; obstructive sleep apnea (OSA); intermittent hypoxia (IH); cellular mechanisms; molecular mechanisms; STOP-Bang; actigraphy; polysomnography; CPAP; BiPAP; obesity; snoring; hypopnea; apnea–hypopnea index

(This special issue belongs to the Section Cellular Pathology)

Heart Development: Mechanisms, Disorders, and Translational Perspectives

edited by

Xiaohai Zhou

, Wenhui Wei and

Yigang Wang

submission deadline 30 Sep 2026 | Viewed by 185 | Submission Open

Keywords: heart development; cardiac morphogenesis; gene regulatory networks

(This special issue belongs to the Section Reproductive Cells and Development)

Repeat Expansion Diseases: From Molecular Mechanisms to Emerging Therapies

edited by

Patricia Gómez-Suaga

and Naomi Hartopp

submission deadline 30 Sep 2026 | Viewed by 185 | Submission Open

Keywords: repeat expansion disease; short tandem repeats; pathogenic mechanisms; long-read sequencing; therapeutic strategies

(This special issue belongs to the Section Cellular Pathology)

Advances in Aging-Related Hyperphosphatemia

edited by

Elena Alcalde-Estévez

and

Susana López-Ongil

submission deadline 30 Sep 2026 | Viewed by 181 | Submission Open

Keywords: hyperphosphatemia; age-related diseases; cellular senescence; biomarkers; sarcopenia; endothelial dysfunction

(This special issue belongs to the Section Cellular Aging)

Allergen-Specific Immune Cell Responses

edited by

Rudolf Valenta

and Maria G. Byazrova

submission deadline 30 Sep 2026 | Viewed by 169 | Submission Open

Keywords: allergen; allergic sensitization; allergen-specific IgE; B cells; T cells

(This special issue belongs to the Section Cellular Immunology)

Mitochondrial Dynamics and Quality Control in Neuromuscular Health and Disease

edited by Kai Zou

submission deadline 30 Sep 2026 | Viewed by 163 | Submission Open

Keywords: mitochondrial dynamics; mitophagy; neuromuscular disorders; axonal transport; metabolic dysfunction; neurodegeneration; skeletal muscle homeostasis; mitochondrial biogenesis; organelle crosstalk.

(This special issue belongs to the Section Mitochondria)

Advance in Glycation End-Products in Aging and Metabolic Diseases

edited by Aleksandra Twarda-Clapa

submission deadline 30 Sep 2026 | Viewed by 162 | Submission Open

Keywords: advanced glycation end-products; AGEs; AGE receptors; scavenger receptors; signalling pathways; AGE-related diseases; inflammation; aging; metabolic diseases; anti-AGE therapies

(This special issue belongs to the Section Cellular Aging)

Cellular and Molecular Mechanisms of Aquaporins in Plants

edited by

Farzana Sabir

submission deadline 30 Sep 2026 | Viewed by 151 | Submission Open

Keywords: aquaporins; plant cells; transport regulation

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Role of Reverse Transcriptase in Aging and Age-Related Disease

edited by

Shelby Osburn

submission deadline 30 Sep 2026 | Viewed by 140 | Submission Open

Keywords: aging; age-related disease; reverse transcriptase; NRTI; anti-aging; DNA damage

(This special issue belongs to the Section Cellular Aging)

The Challenges and Opportunities of Mesenchymal Stromal Cells in Regenerative Medicine

edited by

Lucie Bacakova

submission deadline 1 Oct 2026 | 4 articles | Viewed by 4396 | Submission Open

Keywords: mesenchymal stromal cells; mesenchymal stem cells; medicinal signaling cells; multipotent stem cells; paracrine secretion; angiogenesis; immunomodulation; cell therapy; cell-free cell-based therapy; stem cell differentiation; tissue engineering

The Pivotal Role of Tumor Stem Cells in Glioblastoma: Second Edition

edited by

Paola Palumbo

and Silvano J. Santini

submission deadline 1 Oct 2026 | 3 articles | Viewed by 3925 | Submission Open

Keywords: glioblastoma stem cells; resistance; cancer therapy; signaling pathways; tumor microenvironment

Displaying special issue 151-200 on page 4 of 12.

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