Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Research in Osteoporosis submission deadline 30 Nov 2025 | Viewed by 77 | Submission Open
Keywords: osteoporosis; osteosarcopenia; bone– muscle crosstalk; genetics; epigenetics; transcriptomics; biomarkers; therapeutic strategy
(This special issue belongs to the Section Cellular Pathology)
Microautophagy: The Least Known of the Autophagy Strategies
edited by
submission deadline 30 Nov 2025 | Viewed by 70 | Submission Open
Keywords: core autophagy machinery; ESCRT machinery; lysosomophagy; membrane fission; membrane fusion; microautophagy; SNAREs
(This special issue belongs to the Section Autophagy)
Redox Regulation by Nrf2 in Health and Disease
edited by Pandu Gangula
submission deadline 30 Nov 2025 | Viewed by 70 | Submission Open
Keywords: Nrf2; redox; cellular stress response; antioxidant gene regulation; signaling pathway crosstalk; oxidative stress response
Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities
edited by
submission deadline 30 Nov 2025 | Viewed by 63 | Submission Open
Keywords: osteoblasts; osteoclasts; bone remodelling; osteoporosis; skeletal diseases; bone homeostasis; bone interactions; bone crosstalk; targeted therapies
(This special issue belongs to the Section Cellular Pathology)
The Cellular and Molecular Basis of Lifestyle Factors in Cancer Progression and Prevention
edited by Vivek Kumar Kashyap and Himanshu Narayan Singh
submission deadline 30 Nov 2025 | Viewed by 63 | Submission Open
Keywords: lifestyle factors; smoking; alcohol consumption; cancer risk; cancer prevention recommendations; modifiable risk factors
(This special issue belongs to the Section Cellular Pathology)
Emerging Cell Therapies and Regenerative Approaches in Pulmonary Medicine
edited by Renata Kelly Da Palma
submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open
Keywords: cell therapy; lung diseases; tissue regeneration
(This special issue belongs to the Section Tissues and Organs)
Protein and RNA Regulation in Cells
edited by and
submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open
Keywords: gene expression; post-transcriptional regulation; post-translational modifications; non-coding RNAs; regulatory networks; protein degradation; RNA decay
Lung Cancer: Molecular Mechanisms and Therapeutic Opportunities submission deadline 30 Nov 2025 | Viewed by 48 | Submission Open
Keywords: precision oncology; immunotherapy; targeted therapy; genomic characterization; biomarker; microenvironment; non-small cell lung cancer; small cell lung cancer
(This special issue belongs to the Section Cell Microenvironment)
Extracellular Vesicles in Neurodegenerative Diseases: From Biomarker Discovery to Precision Therapeutics
edited by Mangesh Dattu Hade
submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open
Keywords: neurodegenerative diseases; extracellular vesicles; Alzheimer's disease; Parkinson's disease; multiple sclerosis; blood– brain barrier; neuroinflammation; biomarker discovery; EV-based therapeutics; precision medicine
(This special issue belongs to the Section Cellular Aging)
Cellular and Molecular Mechanisms of Hepatobiliary Diseases submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open
Keywords: hepatobiliary diseases; bile metabolism; hepatobiliary models; artificial intelligence; cholestatic diseases; systems medicine; spatio-temporal liver models
(This special issue belongs to the Section Tissues and Organs)
Cellular and Molecular Mechanisms of Wound Repair
edited by
submission deadline 30 Nov 2025 | Viewed by 44 | Submission Open
Keywords: wound healing; cellular mechanisms; tissue remodeling; growth factors; extracellular matrix; tissue regeneration
(This special issue belongs to the Section Cellular Pathology)
Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments
edited by Konrad Talbot
submission deadline 30 Nov 2025 | Viewed by 43 | Submission Open
Keywords: Alzheimer’ s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’ s disease
(This special issue belongs to the Section Cells of the Nervous System)
New Advances in Cardiac and Vascular Physiology
edited by Robert M. Lust
submission deadline 30 Nov 2025 | Viewed by 32 | Submission Open
Keywords: environmental exposure; immune responses; remodeling; receptors; ischemia; pre-conditioning; post-conditioning; heart failure
(This special issue belongs to the Section Tissues and Organs)
The Spatial and Temporal Dynamics of the Tumor Microenvironment
edited by , Abhishek Gupta, Anjali Trivedi and
submission deadline 1 Dec 2025 | Viewed by 365 | Submission Open
Keywords: tumor microenvironment; spatial heterogeneity; spatial transcriptomics; tumor evolution; immune landscape; extracellular matrix; tumor– immune crosstalk; cancer heterogeneity; intra-tumoral heterogeneity; tumor niches
(This special issue belongs to the Section Cell Microenvironment)
Advances in Pulmonary Fibrosis
edited by Sergio Piñeiro Hermida
submission deadline 1 Dec 2025 | Viewed by 152 | Submission Open
Keywords: pulmonary fibrosis; animal models; biomarkers; experimental therapeutics
(This special issue belongs to the Section Cellular Pathology)
The Role of Macrophages and Neutrophils in Chronic Inflammation-Related Disorders submission deadline 5 Dec 2025 | 6 articles | Viewed by 13186 | Submission Open
Keywords: chronic inflammation; neutrophils; macrophages; Alzheimer’ s disease; aging; cardiovascular diseases; obesity; cancer; fibrosis; tissue injury and repair
(This special issue belongs to the Section Cellular Immunology)
New Targets and Therapeutic Approaches Based on Molecular Mechanisms in Tumorigenesis and Cancer Metastasis
edited by
submission deadline 10 Dec 2025 | 2 articles | Viewed by 3485 | Submission Open
Keywords: metastasis; cancer; therapy; precision medicine; cancer stem cells; immuno-oncology; tumor microenvironment; antibody
(This special issue belongs to the Section Cell Microenvironment)
Therapeutic Mechanism of Nervous System Inflammation—Second Edition submission deadline 10 Dec 2025 | 1 articles | Viewed by 1439 | Submission Open
Keywords: neuroinflammation; neurodegeneration; therapy; drug target; cell signaling; cells of nervous system
(This special issue belongs to the Section Cells of the Nervous System)
The Role of Stem Cells in Retinal Conditions
edited by , Theo Empeslidis and Lorenzo Motta
submission deadline 10 Dec 2025 | Viewed by 389 | Submission Open
Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials
(This special issue belongs to the Section Stem Cells)
Role of Ras-Regulated Signal Pathways
edited by
submission deadline 10 Dec 2025 | Viewed by 227 | Submission Open
Keywords: Ras-regulated signaling pathway; MAPK/ERK pathway; PI3K/AKT pathway; Ral-GDS pathway
(This special issue belongs to the Section Cell Signaling)
Cell Death Mechanisms and Therapeutic Opportunities in Glioblastoma
edited by
submission deadline 15 Dec 2025 | 21 articles | Viewed by 63398 | Submission Open
Keywords: apoptosis; autophagy; cell death mechanisms; cell signaling; glioblastoma; therapeutic opportunities
(This special issue belongs to the Section Cells of the Nervous System)
New Advances in Neuroinflammation
edited by and Michael Breckwoldt
submission deadline 15 Dec 2025 | 14 articles | Viewed by 46071 | Submission Open
Keywords: neuroinflammation; biomarkers; neurodegeneration; microglia; astrocytes; oligodendrocytes; neurological diseases; blood-brain barrier; imaging
(This special issue belongs to the Section Cells of the Nervous System)
Focus on Machinery of Cell Death
edited by , Prashanta Kumar Panda and
submission deadline 15 Dec 2025 | 6 articles | Viewed by 14524 | Submission Open
Keywords: cell death; autophagy; apoptosis; necrosis; ferroptosis; metabolism; stem cell biology; infection; aging; development; Alzheimer’ s; neurodegeneration; therapy
(This special issue belongs to the Section Cellular Pathology)
Mitochondria and Metabolism in Cancer Stem Cells (CSCs)
edited by and Christopher Albanese
submission deadline 15 Dec 2025 | 2 articles | Viewed by 2955 | Submission Open
Keywords: cancer stem cells; circulating tumor cells; drug resistance; metabolism; mitochondria; OXPHSOS; mitochondrial DNA (mtDNA); glycolysis; cell cycle; DNA damage; other metabolic processes; oxidative stress; senescence; therapeutic approaches
(This special issue belongs to the Section Stem Cells)
Cell Therapies in Cancer Treatment
edited by
submission deadline 15 Dec 2025 | 1 articles | Viewed by 1524 | Submission Open
Keywords: cellular therapies; cancer; immune
Mechanisms and Therapies in Chronic Pain
edited by Nikesh Kunder and June Bryan I. de la Peña
submission deadline 15 Dec 2025 | 1 articles | Viewed by 661 | Submission Open
Keywords: chronic pain; pain mechanisms; pain targets; opioid alternatives; neurobiology; pre-clinical; translational research; pathophysiology; pain management
(This special issue belongs to the Section Cellular Pathology)
DNA Methylation in Human Health and Disease: From Molecular Mechanisms to Clinical Applications submission deadline 15 Dec 2025 | Viewed by 623 | Submission Open
Keywords: DNA methylation; epigenetics; diseases; biomarkers; functional analysis
(This special issue belongs to the Section Cellular Pathology)
Exclusive Review Papers in Parkinson's Research
edited by and Ronald F. Pfeiffer
submission deadline 15 Dec 2025 | Viewed by 250 | Submission Open
Keywords: Parkinson’ s disease; alpha-synuclein; substantia nigra; mitochondria; non-motor symptoms; dopamine; levodopa
(This special issue belongs to the Section Cellular Aging)
Functions of Cilia
edited by
submission deadline 15 Dec 2025 | Viewed by 88 | Submission Open
Keywords: cilia; cilia-derived vesicles; ciliopathies; neuronal cilia; motile cilia; primary cilia; ciliary secretion; peptidergic signaling; ectosomes
Recent Advances in the Understanding of Neuropsychiatric Illnesses
edited by and
submission deadline 15 Dec 2025 | Viewed by 87 | Submission Open
Keywords: neuropsychiatric disorders; neurodegeneration; synaptic plasticity; neuroinflammation; biomarkers; molecular mechanisms; translational neuroscience; intracellular signaling; neuroimaging
(This special issue belongs to the Section Cells of the Nervous System)
Physics of Cancer: How Mechanobiology Drives Cancer Progression submission deadline 15 Dec 2025 | Viewed by 79 | Submission Open
Keywords: migration and invasion of cancer cells; cytomechanics and adhesive properties; cellular mechanotransduction; mechanical signals; viscoelasticity and stiffness; physics of cancer
AMPK: From Mechanisms to New Therapies submission deadline 15 Dec 2025 | Viewed by 60 | Submission Open
Keywords: metabolism; AMPK; cancer; biosensors; reproduction; metabolic disorders; therapies
Advanced Research in Neurogenesis and Neuroinflammation
edited by
submission deadline 15 Dec 2025 | Viewed by 56 | Submission Open
Keywords: neurogenesis; neuroinflammation; neurodegeneration; neurodegenerative diseases; cognitive functions
(This special issue belongs to the Section Cells of the Nervous System)
The Symphony of Nature—the Precision of Life’s Regulation
edited by Weiguang Wang and Baocheng Liu
submission deadline 15 Dec 2025 | Viewed by 56 | Submission Open
Keywords: protein structure and function; allosteric regulation; conformational switches; enzyme catalysis and modification; molecular machines; molecular regulation; protein folding and misfolding
(This special issue belongs to the Section Cell Methods)
Organ and Tissue Fibrosis: Molecular Signals and Cellular Mechanisms—Second Edition
edited by
submission deadline 15 Dec 2025 | Viewed by 49 | Submission Open
Keywords: fibrosis; scarring; cytokine; myofibroblasts; extracellular matrix; growth factors; mesenchymal transition
(This special issue belongs to the Section Tissues and Organs)
The Cross-Talk Between Obesity and Metabolism
edited by
submission deadline 15 Dec 2025 | Viewed by 48 | Submission Open
Keywords: obesity; metabolic disorders; insulin resistance; adipose tissue; inflammation; glucose metabolism; lipid metabolism; cardiovascular disease; type 2 diabetes; therapeutic targets
The Role of Extracellular Vesicles in Kidney Disease
edited by and Ciro Tetta
submission deadline 15 Dec 2025 | Viewed by 47 | Submission Open
Keywords: extracellular vesicles (EVs); microRNAs (miRs); chronic kidney disease (CKD); acute kidney injury (AKI); regenerative medicine; biomarkers; artificial intelligence (AI); nephrology; urology; precision medicine
(This special issue belongs to the Section Cell Microenvironment)
Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts
edited by Simonetta Masieri and
submission deadline 15 Dec 2025 | Viewed by 46 | Submission Open
Keywords: rhinology; allergy; immunology; environment; pollution; microbiome; inflammation; united airway disease; lymphocyte cells; interleukins
(This special issue belongs to the Section Tissues and Organs)
The Role of Hormone Receptors in Cancers
edited by and Kambiz Hassanzadeh
submission deadline 15 Dec 2025 | Viewed by 28 | Submission Open
Keywords: cancer progression; endocrine therapy resistance; estrogen and androgen receptors; hormone receptors; nuclear receptors; receptor signaling pathways
From Energy Metabolism to Disease: The Multifaceted Roles of Mitochondria
edited by Amy H. Attaway and Saurabh Mishra
submission deadline 15 Dec 2025 | Viewed by 26 | Submission Open
Keywords: mitochondrial oxidation; ROS; aging; disease
Cancer and Immune System Interactions submission deadline 16 Dec 2025 | Viewed by 38 | Submission Open
Keywords: cancer immunology; tumor microenvironment; immune evasion; immunotherapy; tumor– immune interactions; immune checkpoint regulation; translational oncology
(This special issue belongs to the Section Cell Microenvironment)
Molecular Mechanisms of Tumor Pathogenesis
edited by and Alessandro Lavoro
submission deadline 20 Dec 2025 | 7 articles | Viewed by 13286 | Submission Open
Keywords: cancer; therapeutic targets; biomarkers; epigenetics; DNA methylation; microRNAs; somatic mutations; germline mutations; chromatin remodeling; histone modifications
(This special issue belongs to the Section Cellular Pathology)
Physiology of Telocytes
edited by and Mihail E. Hinescu
submission deadline 20 Dec 2025 | 1 articles | Viewed by 3695 | Submission Open
Keywords: telocytes; telopodes; physiology; pathology; tissue homeostasis; regenerative medicine
(This special issue belongs to the Section Cellular Pathology)
Molecular Mechanisms of Cognitive Function and Dysfunction submission deadline 20 Dec 2025 | 1 articles | Viewed by 2343 | Submission Open
Keywords: cognition; neurodevelopment; neurotransmission; molecular mecanisms; signaling; disorders; therapy
(This special issue belongs to the Section Cells of the Nervous System)
Metabolic Hallmarks in Cancer
edited by , Ubaldo Martinez-Outshoorn and Marta Mauro-Lizcano
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1584 | Submission Open
Keywords: cancer; metabolic reprogramming; metabolic adaptation; cancer energy metabolism; glycolysis; the Warburg effect; the reverse Warburg effect; glutamine addiction; the pentose phosphate pathway; cellular and molecular mechanisms; tumor microenvironment; novel therapeutic interventions
(This special issue belongs to the Section Cellular Metabolism)
Microglial Functions in Neurodegenerative Diseases: In Search of Potential Therapeutic Targets
edited by and María Martín Estebané
submission deadline 20 Dec 2025 | Viewed by 241 | Submission Open
Keywords: microglia; inflammation; neural damage; mitochondria; potential targets
(This special issue belongs to the Section Cellular Aging)
Applications of Proteomics in Human Diseases and Treatments submission deadline 20 Dec 2025 | Viewed by 169 | Submission Open
Keywords: biomarkers; clinical proteomics; single-cell proteomics; next-generation proteomics; biofluids; high-throughput proteomics
(This special issue belongs to the Section Cell Methods)
Advanced Research on Genomic Instability and Gene Expression in Developmental Disorders
edited by
submission deadline 20 Dec 2025 | Viewed by 94 | Submission Open
Keywords: development; neurological disease; cancer; genetic; epigenetic
State-of-the-Art Insights into the Cell Microenvironment
edited by
submission deadline 20 Dec 2025 | Viewed by 89 | Submission Open
Keywords: cell microenvironment; stem cells; organoid and 3D culture models
(This special issue belongs to the Section Cell Microenvironment)
Advances in Human Pluripotent Stem Cells submission deadline 20 Dec 2025 | Viewed by 57 | Submission Open
Keywords: human pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells  
(This special issue belongs to the Section Stem Cells)
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