Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 3640
Special Issue Editors
Interests: natural compounds; structure–activity relationship; cell death; oxidative stress; tumor microenvironment; nanotechnology; pharmaceutical analysis; pharmacokinetics; pharmacokinetics/pharmacodynamics modeling; drug discovery and development
Interests: nanoparticles; theranostic; biomedical imaging; cancer therapy
2. 5M Biomed, LLC, Atlanta, GA 30303, USA
Interests: development of engineered magnetic nanomaterials for molecular imaging, drug delivery, theranostics, and in vitro diagnostics
Special Issue Information
Dear Colleagues,
In the challenging battle against cancer, researchers are continually seeking new targets and therapeutic strategies to combat tumor progression and therapeutic resistance. One emerging avenue of exploration lies in identifying and characterizing novel molecular targets involved in tumor progression and the development of resistance to conventional therapies.
Recent advancements in cancer biology have unveiled a multitude of intricate signaling pathways and molecular mechanisms driving tumorigenesis and treatment resistance. These discoveries have paved the way for developing innovative therapeutic agents aimed at disrupting key nodes in these pathways, thereby halting tumor growth and overcoming resistance.
Among the promising targets are various signaling molecules, receptors, and enzymes implicated in cancer cell survival, proliferation, and metastasis. Additionally, the tumor microenvironment, including stromal cells and immune cells, has emerged as a crucial determinant of cancer progression and treatment response, offering novel therapeutic opportunities.
As researchers delve deeper into the intricate landscape of cancer biology, the potential for innovative therapeutic interventions continues to expand. By targeting emerging molecular targets and harnessing the complexities of the tumor microenvironment, the quest for more effective cancer treatments and strategies to overcome therapeutic resistance is propelled forward, offering hope to patients and clinicians alike.
We welcome original research papers and review articles that address the following (but are not limited to) topics:
- Identification and characterization of novel molecular targets involved in tumor progression and therapeutic resistance;
- Mechanisms underlying the development of resistance to conventional cancer therapies, such as chemotherapy, targeted therapy, and immunotherapy;
- Development of innovative therapeutic strategies to overcome resistance mechanisms, including combination therapies and targeted drug delivery systems;
- Investigation of the tumor microenvironment and its influence on treatment response and resistance, including stromal cells, immune cells, and extracellular matrix components;
- Targeting the signaling pathways and key molecules involved in cancer cell survival, proliferation, invasion, and metastasis;
- Harnessing nanotechnology and innovative drug delivery systems for improved tumor targeting, drug release, and efficacy;
- Application of potential drug candidates from natural sources as therapeutic agents in combating tumor progression and overcoming therapeutic resistance.
We hope that this Special Issue can bring together studies and contributions on the subject of emerging targets and therapeutic potential drugs in tumor progression and therapeutic resistance. We expect to highlight significant and representative progress in this field with the intention of fostering further interest in focused areas by the larger anti-cancer research community.
Prof. Dr. Xinyu Wang
Dr. Lei Zhu
Dr. Yuancheng Li
Guest Editors
Manuscript Submission Information
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Keywords
- cancer
- tumor progression
- therapeutic resistance
- molecular targets
- tumor microenvironment
- innovative therapies
- targeted drug delivery
- natural product
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