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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Endoplasmic Reticulum Stress and Human Disease: Lessons from Animal Models

edited by Sébastien Gaumer

submission deadline 15 Jun 2025 | Viewed by 227 | Submission Open

Keywords: endoplasmic reticulum (ER); ER stress; human diseases; neurodegenerative disorders; diabetes; cardiovascular diseases; cancer; animal models; pathomechanisms; therapeutic strategies

(This special issue belongs to the Section Cellular Pathology)

Synaptic Dysregulation in Nervous System Disorders

edited by Pragya Goel

submission deadline 15 Jun 2025 | Viewed by 198 | Submission Open

Keywords: synapses; synaptic transmission; synaptic plasticity; neurodegeneration; neuropsychiatric disorders; neurodevelopmental diseases

Exploring the Structural and Functional Diversity of Proteins: Foundations of Life and Biological Complexity

edited by Jiabei Lin

submission deadline 15 Jun 2025 | Viewed by 144 | Submission Open

Keywords: AAA+ protein; RNA-binding protein; protein kinase; PTMs; protein structure; function; and diseases; protein and RNA homeostasis; neurodegeneration; cancer

Molecular Mechanisms of Tumor Pathogenesis

edited by

Saverio Candido

and Alessandro Lavoro

submission deadline 20 Jun 2025 | 5 articles | Viewed by 9911 | Submission Open

Keywords: cancer; therapeutic targets; biomarkers; epigenetics; DNA methylation; microRNAs; somatic mutations; germline mutations; chromatin remodeling; histone modifications

(This special issue belongs to the Section Cellular Pathology)

Recent Advances in Regenerative Dentistry—Second Edition

edited by

Li Xiao

submission deadline 20 Jun 2025 | 5 articles | Viewed by 7509 | Submission Open

Keywords: oral stem cells; oral tissue regeneration; bioengineering; dental materials; stem cell banking

(This special issue belongs to the Section Tissues and Organs)

Advances in Spermatogenesis

edited by

Zhibing Zhang

and Changmin Niu

submission deadline 20 Jun 2025 | 4 articles | Viewed by 4940 | Submission Open

Keywords: spermatogenesis; mitosis; meiosis; spermiogenesis; omics; organoid culture; infertility; contraception

(This special issue belongs to the Section Reproductive Cells and Development)

Molecular and Cellular Insights into Platelet Function

edited by

Stepan Gambaryan

and

Mikhail A. Panteleev

submission deadline 20 Jun 2025 | 5 articles | Viewed by 3723 | Submission Open

Keywords: platelet; wound healing; fibrinolysis; regeneration and tissue remodeling; angiogenesis; lymphatic development; inflammation and immunity

(This special issue belongs to the Section Cells of the Cardiovascular System)

Molecular Mechanism of Liver Transplantation

edited by Carmen Peralta and Juan Carlos Cutrin

submission deadline 20 Jun 2025 | 1 articles | Viewed by 2943 | Submission Open

Keywords: liver transplantation; ischemia-reperfusion injury; signaling pathways; graft dysfunction; sterile inflammation; liver regeneration; fatty grafts; normothermic machine perfusion; defatting strategies

(This special issue belongs to the Section Tissues and Organs)

Drosophila: Contribution to Cell Research

edited by

Xiaoyan Zheng

submission deadline 20 Jun 2025 | 1 articles | Viewed by 2546 | Submission Open

Keywords: Drosophila; cell research; cell biology; gene function; disease processes; fruit fly

Mechanisms of Antimicrobial Treatment in Human Diseases

edited by

Paolo Gaibani

submission deadline 20 Jun 2025 | 1 articles | Viewed by 2055 | Submission Open

Keywords: multidrug resistance; epidemiology; novel antimicrobial resistance traits

Molecular and Cellular Mechanisms of Central Nervous System Autoimmunity

edited by

Refik Pul

Christoph Kleinschnitz

and

Jelena Skuljec

submission deadline 20 Jun 2025 | 1 articles | Viewed by 1255 | Submission Open

Keywords: neuroimmunity; central nervous system; autoimmunity; immune tolerance; multiple sclerosis; antibody-mediated autoimmunity; cellular immunology; neuroinflammation

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth

edited by Khondoker M. Akram

submission deadline 20 Jun 2025 | 1 articles | Viewed by 1185 | Submission Open

Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth

(This special issue belongs to the Section Cellular Pathology)

T Cells in Inflammation and Cancer

edited by

Kihong Lim

submission deadline 20 Jun 2025 | 1 articles | Viewed by 1007 | Submission Open

Keywords: T cell; immunity; disease; infection; cancer; inflammation; pathology; immunotherapy

(This special issue belongs to the Section Cellular Immunology)

Immunoregulatory Functions of Mesenchymal Stem Cells (MSCs)

edited by

Joni H. Ylostalo

submission deadline 20 Jun 2025 | Viewed by 256 | Submission Open

Keywords: mesenchymal stem cells; MSCs; immunoregulation; immunosuppression

(This special issue belongs to the Section Stem Cells)

Advances in Cell Therapy for Leukemias

edited by Salman Otoukesh and Idoroenyi U. Amanam

submission deadline 20 Jun 2025 | Viewed by 109 | Submission Open

Keywords: acute leukemia; cell therapy; target cell therapy; immunotherapy; bi-specific therapy; relapse leukemia; refractory leukemia

(This special issue belongs to the Section Cell and Gene Therapy)

Current Status and Future Challenges of Liquid Biopsy

edited by

Shuta Ohara

and

Kenichi Suda

submission deadline 25 Jun 2025 | 4 articles | Viewed by 11862 | Submission Open

Keywords: liquid biopsy; biomarker; minimal residual disease (MRD); circulating tumor DNA (ctDNA); tumor-educated platelet (TEP)

(This special issue belongs to the Section Cellular Pathology)

Natural Products and Their Derivatives Against Human Disease

edited by

Mamunur Rashid

submission deadline 25 Jun 2025 | 4 articles | Viewed by 5108 | Submission Open

Keywords: natural products; immunomodulatory; diseases; molecular mechanism of immunity

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Emerging Therapies for Hereditary Ataxia—Second Edition

edited by

Kah-Hui Wong

Patrícia Maciel

and

Piergiorgio La Rosa

submission deadline 25 Jun 2025 | Viewed by 191 | Submission Open

Keywords: hereditary ataxia; movement disorder; emerging neurotherapeutics; complementary and alternative medicines; secondary metabolites; neuroprotection; mitigation of oxidative stress; mitochondria-targeted antioxidants

Gene Editing Therapies for Hereditary Diseases

edited by

Jacques P. Tremblay

submission deadline 25 Jun 2025 | Viewed by 152 | Submission Open

Keywords: gene therapy; base editing; prime editing; genome editing; hereditary diseases

Cellular and Molecular Mechanisms in Gynecological Disorders

edited by

Qiwei Yang

submission deadline 30 Jun 2025 | 11 articles | Viewed by 18230 | Submission Open

Keywords: uterus; ovary; breast; cervix; cancer; endometriosis; leiomyoma; adenomyosis; polycystic ovary syndrome; female infertility; pathways; cell atlas; transcriptome; epigenome

(This special issue belongs to the Section Reproductive Cells and Development)

Understanding Spinal Cord Injury and Repair: From Molecules to Neurocircuits and Multimodal Prostheses

edited by

Yang D. Teng

submission deadline 30 Jun 2025 | 9 articles | Viewed by 17624 | Submission Open

(This special issue belongs to the Section Cells of the Nervous System)

Insight into Cardiomyopathy

edited by Sobuj Mia

submission deadline 30 Jun 2025 | 1 articles | Viewed by 15073 | Submission Open

Keywords: heart failure; ventricular dysfunction; hypertrophic cardiomyopathy; dilated cardiomyopathy; cardiac fibrosis; cardiac hypertrophy; biomarkers

(This special issue belongs to the Section Cells of the Cardiovascular System)

Highlights in Red Blood Cell Research

edited by

Anna Bogdanova

and

Lars Kaestner

submission deadline 30 Jun 2025 | 3 articles | Viewed by 13355 | Submission Open

Keywords: red blood cells; anemia; transfusion; erythropoiesis; signaling

Cellular and Molecular Mechanisms in Immune Regulation

edited by Fábio Rinaldo Santori and Natalia B. Ivanova

submission deadline 30 Jun 2025 | 8 articles | Viewed by 10706 | Submission Open

Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy

(This special issue belongs to the Section Cellular Immunology)

Exclusive Review Papers in Autophagy—Second Edition

edited by

Harald W. Platta

submission deadline 30 Jun 2025 | 4 articles | Viewed by 9441 | Submission Open

Keywords: biquitination; autophagy; peroxisomes; macroautophagy; pexophagy; mitophagy; lysosome; vacuole; organellar homeostasis; posttranslational modifications; lipids; signaling cascades

(This special issue belongs to the Section Autophagy)

Radiation-Induced Brain Injury: Molecular Mechanisms and Therapeutic Strategies

edited by

Feng Ru Tang

submission deadline 30 Jun 2025 | 3 articles | Viewed by 9174 | Submission Open

Keywords: radiation injury; brain; neurological and neuropsychiatric disorders; molecular mechanisms; novel therapeutic approaches

(This special issue belongs to the Section Cells of the Nervous System)

Natural Products in Neurodegenerative Diseases: Current Trends and Future Perspectives

edited by

Anthony Tsarbopoulos

and Nikolaos Kokras

submission deadline 30 Jun 2025 | 2 articles | Viewed by 8174 | Submission Open

Keywords: bioactive compounds; protein aggregation processes in AD; cognitive; anxiolytic and antidepressant effects

(This special issue belongs to the Section Cells of the Nervous System)

Charming Micro-Insights into Health and Diseases

edited by

Alexander E. Kalyuzhny

submission deadline 30 Jun 2025 | 4 articles | Viewed by 7698 | Submission Open

Keywords: cellular pathology of cancers neural cell biology cellular antivirus immune responses cell therapies cellular signaling cell research in animal models cellular metabolism protein quality control proteasomal degradation and autophagy

Male Infertility Update: Current Knowledge on Etiology, Comorbidities, Diagnosis and Treatment: Preclinical Topics

edited by

Francesco Lotti

and

Mario Maggi

submission deadline 30 Jun 2025 | 3 articles | Viewed by 7165 | Submission Open

Keywords: male infertility; diagnosis; treatment; etiology; pre-testicular/testicular/post-testicular causes; genetic causes; seminal parameters; hormonal parameters; ultrasound; general health; azoospermia

(This special issue belongs to the Section Reproductive Cells and Development)

Heat Shock Proteins and Human Cancers

edited by

Alexander E. Kabakov

submission deadline 30 Jun 2025 | 3 articles | Viewed by 6768 | Submission Open

Keywords: heat shock protein; glucose-regulated protein; cancer; tumorigenesis; theranostics; anticancer vaccine

Epigenetics and DNA Repair: Regulatory Mechanisms and Therapeutic Opportunities

edited by

Vasily M. Studitsky

submission deadline 30 Jun 2025 | 3 articles | Viewed by 6338 | Submission Open

Keywords: DNA damage; DNA repair; epigenetics; chromatin; remodeling

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Astrocyte Reprogramming and Brain Homeostasis

edited by Dimitra Thomaidou and Elsa Papadimitriou

submission deadline 30 Jun 2025 | 2 articles | Viewed by 4624 | Submission Open

Keywords: in vitro astrocytic reprogramming; in vivo astrocytic reprogramming; induced neurons; transcription factors; miRNAs; small molecules; direct reprogramming mechanisms; scRNA-seq; gene regulatory networks; astrocytic metabolism; metabolic reprogramming

(This special issue belongs to the Section Cells of the Nervous System)

Synaptic Plasticity in Brain and Nerves: New Vistas in Health and Diseases (2nd Edition)

edited by

Jean-Marie Billard

submission deadline 30 Jun 2025 | 2 articles | Viewed by 4063 | Submission Open

Keywords: cellular networks; synaptic strength; Hebbian plasticity; homeostatic plasticity; neuron– glia interactions; brain disorders; cognitive functions

(This special issue belongs to the Section Cells of the Nervous System)

Kynurenic Acid: Unveiling Its Impact on the Brain’s Neurotransmission and Neurological Disorders

edited by Korrapati V. Sathyasaikumar, Sarah Beggiato and

Verónica Pérez de la Cruz

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3544 | Submission Open

Keywords: kynurenic acid; cognition; aging; neuromodulation; neurodegeneration; neurodevelopment; neuroinflammation; tryptophan catabolism

(This special issue belongs to the Section Cell Signaling)

Cellular Signaling and Therapeutic Approaches of Pulmonary Fibrosis

edited by Jennifer Speth

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3304 | Submission Open

Keywords: pulmonary fibrosis; resolution; cellular interactions

(This special issue belongs to the Section Tissues and Organs)

Advancements in Cellular Immunotherapies in the Immune Checkpoint Inhibitor Era for Cancer Treatment

edited by

Andrés Tittarelli

and

Flavio Salazar-Onfray

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3281 | Submission Open

Keywords: CAR-T cells; NK-cell immunotherapy; adoptive T-cell transfer; dendritic cell cancer vaccines; whole-tumor-cell vaccines

(This special issue belongs to the Section Cellular Immunology)

Advances in Melanoma Immunotherapy

edited by Jeffrey D. McBride

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3158 | Submission Open

Keywords: melanoma immunotherapy; therapeutic targets; immune modulation; oncolytic viruses; checkpoint inhibitors; cancer vaccines; tumor biomarkers; tumor microenvironment; treatment strategies

(This special issue belongs to the Section Cellular Immunology)

Recent Developments in the Role of Enteroendocrine Cells in Gastrointestinal and Non-gastrointestinal Disorders

edited by

Tarek Mazzawi

and Trygve Hausken

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2897 | Submission Open

Keywords: enteroendocrine; stem cells; quantification; transcriptome; immunohistochemistry; gut hormones; obesity; Parkinson’ s disease; diabetes; IBD

Axonal Transport: Mechanisms, Disorders, and Therapeutic Approaches

edited by Yuxiang Xie and Jingqi Yan

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2637 | Submission Open

Keywords: axonal transport; motor proteins; autophagy– lysosome pathway; neurodegenerative diseases; therapeutic strategies

Novel and Experimental Strategies for the Treatment of Neurodegenerative Diseases

edited by

Morten Meyer

and Justyna Okarmus

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2548 | Submission Open

Keywords: neurodegenerative diseases; experimental treatments; stem cell transplantation; immunotherapy; gene therapy; focused ultrasound; neuroprotective agents; Parkinson's disease; Alzheimer's disease; Huntington’ s disease; amyotrophic lateral sclerosis

(This special issue belongs to the Section Cells of the Nervous System)

The Role of Inflammation in AMD (Multifactorial Age-Related Macular Degeneration)—Volume II

edited by Kai Kaarniranta,

Anu Kauppinen

and

Heping Xu

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2384 | Submission Open

Keywords: aging; autophagy; degeneration; inflammation; macula; oxidative stress; retina

(This special issue belongs to the Section Cellular Immunology)

The Role of Oxidative Stress in Cardiovascular Diseases—2nd Edition

edited by

Liya Yin

and

Chuanxi Cai

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2204 | Submission Open

Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species

(This special issue belongs to the Section Cells of the Cardiovascular System)

The Role of Hypoxia-Inducible Factors (HIFs) in Human Diseases

edited by

Efrosyni Paraskeva

and

George Simos

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1988 | Submission Open

Keywords: oxygen; hypoxia; HIF; transcription; cancer; anemia; ischemia; cardiovascular disorders; erythrocytosis; pulmonary hypertension

(This special issue belongs to the Section Cellular Pathology)

Sepsis: Pathogenesis, Pathophysiology, Molecular and Cellular Mechanisms and Immunity

edited by

Guozheng Wang

and

Simon Abrams

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1927 | Submission Open

Keywords: sepsis; bacterial infection; PAMPs; DAMPs; TLRs; small RNAs; RNA splicing; DNA recombination; signaling pathways; cell death; NET/NETosis; coagulopathy; DIC; toxins; complements

(This special issue belongs to the Section Cellular Immunology)

New Discoveries in Calcium Signaling-Related Neurological Disorders

edited by Matheus De Castro Fonseca

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1803 | Submission Open

Keywords: Ca2+ signaling; neurons; neurological disorders; intracellular signaling; synaptic dysfunction

(This special issue belongs to the Section Cells of the Nervous System)

Research on the Amyloid in Alzheimer’s Disease

edited by Archna Sharma

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1685 | Submission Open

Keywords: amyloid; Alzheimer’ s disease; amyloid biomarkers; brain network; anti-amyloid immunotherapy; inducible pluripotent stem cells; neuron and non-neuron differentiation; brain organoids; amyloidopathy animal models

(This special issue belongs to the Section Cellular Aging)

Gastrointestinal Cancer: From Cellular and Molecular Mechanisms to Therapeutic Opportunities

edited by

Federica Laudisi

and

Carmine Stolfi

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1504 | Submission Open

Keywords: colorectal cancer; gastric cancer; liver cancer; pancreatic cancer; tumor microenvironment; cytokines; epigenetic; checkpoint inhibitors; biomarkers; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

Role of Zinc in Brain Homeostasis and Neurological Disorders

edited by Richard Dyck

submission deadline 30 Jun 2025 | Viewed by 1321 | Submission Open

Keywords: zinc; neurotransmitter; neuromodulator; homeostasis; zinc transporters; ZnTs; Slc30; ZIPs; Slc39

(This special issue belongs to the Section Cells of the Nervous System)

Novel Insights into Molecular Mechanisms of Renal Fibrosis

edited by