Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exploring New Treatments: Innovative Strategies Based on the Mechanism and Pathogenesis of Neurodevelopmental Disorders submission deadline 30 Sep 2026 | Viewed by 476 | Submission Open
Keywords: rett syndrome; fragile X; GABA; seizures; cognition; Cdkl5 deficiency disorder; motor deficits; developmental delay
Heat Shock Proteins and Human Cancers—2nd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 469 | Submission Open
Keywords: heat shock protein; glucose-regulated protein; cancer; tumorigenesis; theranostics; anticancer vaccine
Paradigm-Challenging Research and Out-of-the-Box (OB) Hypotheses submission deadline 30 Sep 2026 | Viewed by 446 | Submission Open
Multi-Omics Technologies in Immunity Within Tumors submission deadline 30 Sep 2026 | Viewed by 440 | Submission Open
Keywords: multi-omics; proteomics; metabolomics; lipidomics; genomics and epigenomics; synergistic combinations for cancer; AI applications in multi-omics integrations; tumor microenvironment (TME); cancer immunotherapy; immuno-oncology; integrative analysis of multi-omics; biomarkers; precision medicine; tumor heterogeneity
Astrocytes: Roles and Functions in the Brain submission deadline 30 Sep 2026 | Viewed by 407 | Submission Open
Keywords: astrocyte biology; glial cells; synaptic regulation; CNS disorders; neuroinflammation; blood–brain barrier; brain metabolism; reactive astrocytes; neuron–glia interaction; therapeutic targeting
Oral Disease: Cellular Mechanisms and Emerging Therapeutic Strategies
edited by and Marziyeh Aghazadeh
submission deadline 30 Sep 2026 | Viewed by 394 | Submission Open
Keywords: oral diseases; amelogenesis; dentinogenesis; periodontitis; dental fluorosis; oral manifestations of systemic diseases; oral squamous cell carcinoma; leukoplakia; erythroplakia
(This special issue belongs to the Section Cellular Pathology)
Sickle Cell Disease: Pathogenesis and Therapies
edited by and Geoffrey Cheminet
submission deadline 30 Sep 2026 | Viewed by 390 | Submission Open
Keywords: sickle cell disease; erythrocyte sickling; chronic inflammation; endothelial dysfunction; hematopoietic stem cell transplantation
(This special issue belongs to the Section Cellular Pathology)
Applications of Organ-on-a-Chip Model in Vascular Disease
edited by Abidemi Junaid and Netanel Korin
submission deadline 30 Sep 2026 | Viewed by 326 | Submission Open
Keywords: organ‑on‑a‑chip; microfluidics; vascular disease; endothelial dysfunction; hemodynamics and shear stress; thrombosis and inflammation; drug screening; precision medicine
(This special issue belongs to the Section Cells of the Cardiovascular System)
Immune Cell Signaling Networks: Receptors, Second Messengers and Gene Programs
edited by
submission deadline 30 Sep 2026 | Viewed by 322 | Submission Open
Keywords: immune signaling; receptor signaling; cytokine receptors; immune cells; infectious disease
(This special issue belongs to the Section Cell Signaling)
Molecular Mechanisms and Biomarker Development in Prostate Cancer
edited by Vikas Mehta and Behtash Ghazi Nezami
submission deadline 30 Sep 2026 | Viewed by 320 | Submission Open
Keywords: androgen receptor; prostate molecular alterations; biomarkers
Molecular and Cellular Advances in Understanding Early Embryo Development—3rd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 294 | Submission Open
Keywords: metabolism; biomembrane transport; genetics; epigenetic modifications; transgenerational inheritance; signaling; ART; in vitro culture; trophectoderm; inner cell mass
(This special issue belongs to the Section Reproductive Cells and Development)
Pathogenesis and Therapies of Chronic Obstructive Lung Diseases
edited by
submission deadline 30 Sep 2026 | Viewed by 272 | Submission Open
Keywords: chronic obstructive pulmonary disease; COPD; asthma; airway inflammation; lung remodeling; oxidative stress; animal models; epithelial dysfunction; therapeutic targeting
(This special issue belongs to the Section Cellular Pathology)
How the DNA Damage Response Modifies Transcription Regulators
edited by Norbert Lehming
submission deadline 30 Sep 2026 | Viewed by 254 | Submission Open
Keywords: DNA damage; chromatin; gene expression; conditional mRNA degradation; DNA repair; cancer; apoptosis
Repeat Expansion Diseases: From Molecular Mechanisms to Emerging Therapies
edited by and Naomi Hartopp
submission deadline 30 Sep 2026 | 1 articles | Viewed by 246 | Submission Open
Keywords: repeat expansion disease; short tandem repeats; pathogenic mechanisms; long-read sequencing; therapeutic strategies
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms of Obstructive Sleep Apnea
edited by Jivan Lamichhane, Abhishek Thakur and
submission deadline 30 Sep 2026 | Viewed by 243 | Submission Open
Keywords: sleep; sleep apnea; obstructive sleep apnea (OSA); intermittent hypoxia (IH); cellular mechanisms; molecular mechanisms; STOP-Bang; actigraphy; polysomnography; CPAP; BiPAP; obesity; snoring; hypopnea; apnea–hypopnea index
(This special issue belongs to the Section Cellular Pathology)
Neuron–Glia Synergy and Dysfunction in Parkinson’s Disease
edited by
submission deadline 30 Sep 2026 | Viewed by 240 | Submission Open
Keywords: Parkinson’s disease; neuron–glia interactions; neuroinflammation; glial cells dysfunction
(This special issue belongs to the Section Cellular Neuroscience)
Allergen-Specific Immune Cell Responses
edited by and Maria G. Byazrova
submission deadline 30 Sep 2026 | Viewed by 236 | Submission Open
Keywords: allergen; allergic sensitization; allergen-specific IgE; B cells; T cells
(This special issue belongs to the Section Cellular Immunology)
DNA Damage in Neurodegeneration
edited by and Sofia Francia
submission deadline 30 Sep 2026 | Viewed by 235 | Submission Open
Keywords: DNA damage; neurodegeneration; DNA repair; oxidative stress; genomic instability; neuronal cell death; aging; animal models; cellular senescence
(This special issue belongs to the Section Cellular Neuroscience)
Heart Development: Mechanisms, Disorders, and Translational Perspectives
edited by , Wenhui Wei and
submission deadline 30 Sep 2026 | Viewed by 233 | Submission Open
Keywords: heart development; cardiac morphogenesis; gene regulatory networks
(This special issue belongs to the Section Reproductive Cells and Development)
Advances in Aging-Related Hyperphosphatemia submission deadline 30 Sep 2026 | Viewed by 219 | Submission Open
Keywords: hyperphosphatemia; age-related diseases; cellular senescence; biomarkers; sarcopenia; endothelial dysfunction
(This special issue belongs to the Section Cellular Aging)
Advance in Glycation End-Products in Aging and Metabolic Diseases
edited by Aleksandra Twarda-Clapa
submission deadline 30 Sep 2026 | Viewed by 201 | Submission Open
Keywords: advanced glycation end-products; AGEs; AGE receptors; scavenger receptors; signalling pathways; AGE-related diseases; inflammation; aging; metabolic diseases; anti-AGE therapies
(This special issue belongs to the Section Cellular Aging)
Cellular and Molecular Mechanisms of Aquaporins in Plants
edited by
submission deadline 30 Sep 2026 | Viewed by 196 | Submission Open
Keywords: aquaporins; plant cells; transport regulation
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Role of Reverse Transcriptase in Aging and Age-Related Disease
edited by
submission deadline 30 Sep 2026 | Viewed by 184 | Submission Open
Keywords: aging; age-related disease; reverse transcriptase; NRTI; anti-aging; DNA damage
(This special issue belongs to the Section Cellular Aging)
The Challenges and Opportunities of Mesenchymal Stromal Cells in Regenerative Medicine
edited by
submission deadline 1 Oct 2026 | 4 articles | Viewed by 4957 | Submission Open
Keywords: mesenchymal stromal cells; mesenchymal stem cells; medicinal signaling cells; multipotent stem cells; paracrine secretion; angiogenesis; immunomodulation; cell therapy; cell-free cell-based therapy; stem cell differentiation; tissue engineering
The Pivotal Role of Tumor Stem Cells in Glioblastoma: Second Edition
edited by and Silvano J. Santini
submission deadline 1 Oct 2026 | 3 articles | Viewed by 4339 | Submission Open
Keywords: glioblastoma stem cells; resistance; cancer therapy; signaling pathways; tumor microenvironment
Advances in Matrix Metalloproteinase Research for Cancer Detection and Therapy
edited by Neha Atale, Vibha Rani and
submission deadline 1 Oct 2026 | Viewed by 420 | Submission Open
Keywords: cancer; chemotherapy; EMT (epithelial to mesenchymal transition); matrix metalloproteinase; metastasis; metalloproteinase inhibitors; natural MMP inhibitors; tumor microenvironment
Human Brain Development: Insights from Experimental and Stem Cell-Based Models
edited by Nicole Amberg
submission deadline 1 Oct 2026 | Viewed by 250 | Submission Open
Keywords: progenitor cells; neurons; glia; regional identity; neurodevelopmental disorders; cerebral organoids; iPSCs
(This special issue belongs to the Section Cellular Neuroscience)
Mitochondria: Multifaceted Regulators of Cell Death
edited by Rasa Banienė and Sonata Trumbeckaite
submission deadline 10 Oct 2026 | 1 articles | Viewed by 1337 | Submission Open
Keywords: mitochondria; cell death; multifaceted regulators; reactive oxygen species (ROS); cell metabolism; mitochondrial transfer
Integrating Advanced Cellular Models in Radiation Biology: From Electromagnetic Fields to Photons and Emerging Particle Modalities
edited by and
submission deadline 10 Oct 2026 | 1 articles | Viewed by 772 | Submission Open
Keywords: ionizing radiation; particle radiation; electromagnetic; radiation biology; cell cultures; preclinical models
(This special issue belongs to the Section Cellular Biophysics)
New Advances in Proteomics for Understanding Health and Disease
edited by
submission deadline 10 Oct 2026 | Viewed by 452 | Submission Open
Keywords: mass spectrometry; single-cell proteomics; plasma proteomics; systems biology; cancer biology; health and disease; precision medicine; protein networks; clinical proteomics; multi-omics integration
(This special issue belongs to the Section Cell Methods)
Latest Advances in Molecular and Cellular Mechanisms of Alzheimer's Disease in Canada submission deadline 10 Oct 2026 | Viewed by 321 | Submission Open
Keywords: Alzheimer's disease; neurodegeneration; amyloid-beta; protein aggregation; chaperone proteins; neuroinflammation; cerebrovascular system; CD2AP; blood–brain barrier; cholinergic neurons, neuronal regeneration; gut–brain axis; GSK3; BACE1; CD33 isoforms; translational neuroscience
(This special issue belongs to the Section Cellular Neuroscience)
The Effects of Stress on Cells and Organisms submission deadline 10 Oct 2026 | Viewed by 295 | Submission Open
Keywords: stress; biological stress; stress response; TEs activity following stress; heat-shock proteins; epigenetic control of the stress; stress granules; alteration of metabolism following stress; stress adaptation; stress-related diseases
Advances in Zebrafish Disease Models submission deadline 15 Oct 2026 | 4 articles | Viewed by 12430 | Submission Open
Keywords: zebrafish; human disease models; experimental disease models; novel drugs and therapies; organic diseases; functional disorders
Molecular and Cellular Insights into Platelet Function, 2nd Edition submission deadline 15 Oct 2026 | 6 articles | Viewed by 8906 | Submission Open
Keywords: platelet; wound healing; fibrinolysis; regeneration and tissue remodeling; angiogenesis; lymphatic development; inflammation and immunity
Gut Dysbiosis in Inflammatory Diseases
edited by Weiwei Liu
submission deadline 15 Oct 2026 | 3 articles | Viewed by 7134 | Submission Open
Keywords: gut microbiota; innate and adaptive immunity; dysbiosis; metabolism; inflammatory bowel diseases; autoimmune diseases; metabolic disorders; fecal microbiota transplantation
(This special issue belongs to the Section Cellular Pathology)
Cellular Mechanisms in Pregnancy and Foetal Development submission deadline 15 Oct 2026 | 5 articles | Viewed by 7032 | Submission Open
Keywords: pregnancy; fetus; reproduction; placenta; maternal; fertility; preeclampsia; fetal growth restriction; gestational diabetes; stillbirth
T Cells in Inflammation and Cancer
edited by
submission deadline 15 Oct 2026 | 2 articles | Viewed by 6413 | Submission Open
Keywords: T cell; immunity; disease; infection; cancer; inflammation; pathology; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Lung Diseases: From Cellular and Molecular Mechanisms to Targeted Therapies submission deadline 15 Oct 2026 | 1 articles | Viewed by 4728 | Submission Open
Keywords: lung diseases; cellular and molecular mechanisms; targeted therapies; OMICS; single-cell sequencing
The Artificial Intelligence to the Rescue of Cancer Research submission deadline 15 Oct 2026 | 2 articles | Viewed by 4395 | Submission Open
Keywords: cancer research; artificial intelligence; personalized medicine; multi-omics data integration; AI-driven drug discovery; precision medicine
(This special issue belongs to the Section Cell Methods)
Cellular and Molecular Studies of the Adrenal Gland
edited by Wen-Jun Shen, and Salman Azhar
submission deadline 15 Oct 2026 | 1 articles | Viewed by 1054 | Submission Open
Keywords: adrenal zonation; steroid hormones; steroidogenesis; congenital adrenal hyperplasia; hyperaldosteronism; Cushing’s syndrome
Advances in Skin Physiopathology
edited by Monica Ottaviani, and
submission deadline 15 Oct 2026 | 2 articles | Viewed by 692 | Submission Open
Keywords: dermatological diseases; skin aging; inflammation-associated skin diseases; skin cancer; skin microbiome; 3D cell models
(This special issue belongs to the Section Cellular Pathology)
Regenerative Medicine for Bone and Dental Tissues: Biology and Applications submission deadline 15 Oct 2026 | Viewed by 216 | Submission Open
Keywords: bone regeneration; dental tissue regeneration; stem and progenitor cells; biomaterials and bioactive scaffolds; translational regenerative strategies
(This special issue belongs to the Section Tissues and Organs)
Molecular and Cellular Mechanisms of Inherited Retinal Dystrophies
edited by Rosellina Guarascio, and
submission deadline 15 Oct 2026 | Viewed by 197 | Submission Open
Keywords: retinal degeneration; photoreceptors; RPE; phototransduction; connecting cilium; retinoid cycle; protein folding; inflammation; oxidative stress; light damage
(This special issue belongs to the Section Cellular Pathology)
Age-Related Macular Degeneration (AMD): From Cellular and Molecular Mechanisms to Therapies
edited by
submission deadline 15 Oct 2026 | Viewed by 158 | Submission Open
Keywords: age‑related macular degeneration; cellular mechanism; molecular mechanism; gene therapies; neuroprotective strategies
(This special issue belongs to the Section Cellular Aging)
Advances in Muscle Research in Health and Disease—2nd Edition
edited by
submission deadline 20 Oct 2026 | 4 articles | Viewed by 13764 | Submission Open
Keywords: skeletal muscle; cardiac muscle; smooth muscle; myocyte; vascular smooth muscle cell; stem cell; development; homeostasis; regeneration; biomarker; therapeutic target
(This special issue belongs to the Section Tissues and Organs)
Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance
edited by , and Yuancheng Li
submission deadline 20 Oct 2026 | 4 articles | Viewed by 11838 | Submission Open
Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product
(This special issue belongs to the Section Cell Microenvironment)
Lung Cancer: Molecular Mechanisms and Therapeutic Opportunities submission deadline 20 Oct 2026 | 3 articles | Viewed by 5912 | Submission Open
Keywords: precision oncology; immunotherapy; targeted therapy; genomic characterization; biomarker; microenvironment; non-small cell lung cancer; small cell lung cancer
(This special issue belongs to the Section Cell Microenvironment)
From Energy Metabolism to Disease: The Multifaceted Roles of Mitochondria
edited by Amy H. Attaway and Saurabh Mishra
submission deadline 20 Oct 2026 | 2 articles | Viewed by 4324 | Submission Open
Keywords: mitochondrial oxidation; ROS; aging; disease
Vascular Biology: From Molecular Mechanisms to Precision Therapies
edited by Payaningal R. Somanath
submission deadline 20 Oct 2026 | 2 articles | Viewed by 2974 | Submission Open
Keywords: angiogenesis; endothelium; vascular permeability; blood–tissue barrier; organ injury
PI3K/AKT/mTOR Signaling Network in Human Health and Diseases, 3rd Edition
edited by , and
submission deadline 20 Oct 2026 | 1 articles | Viewed by 2858 | Submission Open
Keywords: acne; ageing; Akt; Alzheimer’s disease; autophagy; autoimmunity; PI3K; mTOR; cancer; cardiovascular diseases; diabetes; growth; hamartoma; hypertrophy; inflammation; neurologic; tuberous sclerosis; systemic sclerosis; obesity; Parkinson’s disease; psoriasis; atopic dermatitis; burns/wound healing; targeted therapy; natural products; biologics
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