Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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MET: Signaling, Regulation, and Biological Roles
edited by Abdulhameed Al-Ghabkari and William W. Lockwood
submission deadline 15 Jul 2026 | Viewed by 81 | Submission Open
Keywords: MET; HGF (hepatocyte growth factor); MET signaling; receptor tyrosine kinase (RTK); cancer; tumor progression; receptor activation; MET-targeted therapy
(This special issue belongs to the Section Cell Signaling)
Second Edition of Advances in Adipose Tissue Biology
edited by
submission deadline 20 Jul 2026 | 2 articles | Viewed by 4646 | Submission Open
Keywords: adipocyte differentiation; progenitors; and stem cells; adipokines; myokines; hepatokines; cytokines; cellular signaling; and molecular crosstalk; white adipose tissue (WAT) and brown adipose tissue (BAT); beige fat and browning of WAT; research techniques and methodologies; diagnostics and therapeutics; genomics; metabolomics; other ‘ omics’ technologies; metabolic syndrome; obesity; insulin resistance; cancer
(This special issue belongs to the Section Tissues and Organs)
Applications of Nanotechnology and Molecular Imaging in Cancer
edited by and Victoria Laney
submission deadline 20 Jul 2026 | Viewed by 10 | Submission Open
Keywords: contrast agents and mechanisms; probes; molecular imaging; longitudinal imaging; tumor microenvironment; nanomaterials; cell signaling; cancer therapy; intracellular pathways; imaging-guided treatment
Novel Molecular Targets for the Treatment of Sleep Disorders
edited by
submission deadline 25 Jul 2026 | Viewed by 307 | Submission Open
Keywords: sleep disorders; molecular targets; glymphatic system; neuroinflammation; circadian rhythms; microbiome; biomarkers; pharmacological therapy; gene therapy; neurodegeneration
Toxicology in Cells: Cellular Mechanisms, Molecular Responses, and Modern Models
edited by Maria Jurczuk and
submission deadline 30 Jul 2026 | Viewed by 83 | Submission Open
Keywords: cellular toxicology; oxidative stress; apoptosis; autophagy; biomarkers; nanotoxicology; organ-on-chip; toxicogenomics; epigenetic regulation; mitochondrial dysfunction
Mitochondria in Cancer Immune Evasion and Immunotherapy
edited by Loredana Moro and
submission deadline 30 Jul 2026 | Viewed by 56 | Submission Open
Keywords: mitochondria; mtDNA; immunity; cancer immune evasion; tumor microenvironment; immune tolerance; lymphocytes; inflammation; immune response
(This special issue belongs to the Section Cellular Immunology)
New Advances in Immunomodulation Using Biomaterials
edited by and Vaishali Inamdar
submission deadline 30 Jul 2026 | Viewed by 1 | Submission Open
Keywords: immunomodulation; biomaterials; cell– material interactions; biocompatibility; immune system
Cellular Mechanisms of Anti-Cancer Therapies
edited by Ilgen Mender and
submission deadline 31 Jul 2026 | 8 articles | Viewed by 17319 | Submission Open
Keywords: anti-cancer therapies; innovative treatment strategies; cellular mechanisms; drug resistance; personalized medicine
(This special issue belongs to the Section Cellular Pathology)
How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies submission deadline 31 Jul 2026 | 5 articles | Viewed by 8403 | Submission Open
Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention
(This special issue belongs to the Section Cell Microenvironment)
Advances in the Discovery of Retinal Degeneration submission deadline 31 Jul 2026 | 5 articles | Viewed by 6445 | Submission Open
Keywords: retinal cell biology; photoreceptors; oxidative stress; inflammation; blood– retinal barriers; diabetic retinopathy; clinical eye research; inherited retinal diseases; ocular immunology
(This special issue belongs to the Section Cellular Pathology)
Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities
edited by
submission deadline 31 Jul 2026 | 3 articles | Viewed by 4957 | Submission Open
Keywords: osteoblasts; osteoclasts; bone remodelling; osteoporosis; skeletal diseases; bone homeostasis; bone interactions; bone crosstalk; targeted therapies
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms of Vascular-Related Diseases
edited by and
submission deadline 31 Jul 2026 | 3 articles | Viewed by 4345 | Submission Open
Keywords: cellular and molecular mechanisms; cardiovascular disease; cerebrovascular disease; vascular signaling; vascular dysfunctions in cns disorders; vascular dysfunctions in diabetes; vascular dysfunction in chronic kidney disease; tumor metastasis via vascular system
(This special issue belongs to the Section Cellular Pathology)
Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health
edited by
submission deadline 31 Jul 2026 | Viewed by 344 | Submission Open
Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines
Molecular Research in Osteoporosis submission deadline 31 Jul 2026 | Viewed by 253 | Submission Open
Keywords: osteoporosis; osteosarcopenia; bone– muscle crosstalk; genetics; epigenetics; transcriptomics; biomarkers; therapeutic strategy
(This special issue belongs to the Section Cellular Pathology)
Immunometabolic Reprogramming in Diabetic Kidney Disease: The Interplay of Innate Immunity, Oxidative Stress, and Cellular Metabolism
edited by , Sandra Kostić and Anita Racetin
submission deadline 31 Jul 2026 | Viewed by 187 | Submission Open
Keywords: diabetic kidney disease; immunometabolism; innate immunity; oxidative stress; metabolic reprogramming; inflammasome; renal fibrosis; mitochondrial dysfunction; non-coding RNAs; multi-omics integration
Advances in Toxoplasma gondii Treatment, Immunology and Host–Parasite Interaction
edited by Namrata Anand
submission deadline 31 Jul 2026 | Viewed by 166 | Submission Open
Keywords: T. gondii; treatment strategies; secretory proteins; immune response; exosomes; nanoparticle; congenital infection; host– parasite interaction
(This special issue belongs to the Section Cellular Immunology)
ALK Signaling Pathways in NSCLC: From Cell Biology to Therapeutic Insights submission deadline 31 Jul 2026 | Viewed by 87 | Submission Open
Keywords: anaplastic lymphoma kinase (ALK); non-small-cell lung cancer (NSCLC); ALK tyrosine kinase inhibitors (ALK-TKIs); drug resistance; signal transduction and oncogenic pathways; molecular diagnostics (IHC; FISH; NGS); targeted therapy
Extracellular Vesicles: Drivers, Biomarkers and Therapeutics in Cardiovascular Disease submission deadline 31 Jul 2026 | Viewed by 74 | Submission Open
Keywords: cardiovascular disease; extracellular vesicles; biomarkers; therapeutics; drug delivery; RNA therapeutics; fibrosis; atherosclerosis; liquid biopsy
Recent Advances in Vitamin D and K in Cancer submission deadline 31 Jul 2026 | Viewed by 37 | Submission Open
Keywords: vitamin D; vitamin K; VDR signaling; tumor microenvironment; cancer prevention; molecular pathways; apoptosis and proliferation; oxidative stress; immunomodulation; therapeutic resistance
Sex Differences in Molecular Mechanisms Linking Neuronal Stress and Inflammation
edited by John R. Bethea and Kayla Lee Nguyen
submission deadline 31 Jul 2026 | Viewed by 15 | Submission Open
Keywords: ER stress; intracellular signaling; neuronal stress; immune activation; sex differences; neuro-immune interactions
(This special issue belongs to the Section Cellular Neuroscience)
Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer—2nd Edition
edited by Sachin Mulik, Weshely Kujur, and Sumit Sen Santara
submission deadline 31 Jul 2026 | Viewed by 15 | Submission Open
Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes
(This special issue belongs to the Section Cellular Immunology)
Molecular Mechanisms to Treatment Progress of Ovarian Cancer
edited by Amal M. El-Naggar
submission deadline 31 Jul 2026 | Submission Open
Keywords: ovarian cancer; molecular mechanisms; therapeutic targets; drug resistance; biomarkers; preclinical models; targeted therapy; immunotherapy; tumor microenvironment; translational research
(This special issue belongs to the Section Reproductive Cells and Development)
Focus on Machinery of Cell Death
edited by , Prashanta Kumar Panda and
submission deadline 10 Aug 2026 | 8 articles | Viewed by 20346 | Submission Open
Keywords: cell death; autophagy; apoptosis; necrosis; ferroptosis; metabolism; stem cell biology; infection; aging; development; Alzheimer’ s; neurodegeneration; therapy
(This special issue belongs to the Section Cellular Pathology)
Cell Therapies in Cancer Treatment
edited by
submission deadline 10 Aug 2026 | 1 articles | Viewed by 2632 | Submission Open
Keywords: cellular therapies; cancer; immune
The Role of Stem Cells in Retinal Conditions
edited by , Theo Empeslidis and Lorenzo Motta
submission deadline 10 Aug 2026 | Viewed by 542 | Submission Open
Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials
(This special issue belongs to the Section Stem Cells)
Study on Ovarian Follicle Development
edited by Cecily V. Bishop and Jessica Cristina Lemos Motta
submission deadline 10 Aug 2026 | Viewed by 184 | Submission Open
Keywords: follicular development; ovarian follicle activation; ovarian reserve; in vitro follicle culture; translational reproductive biology
Physics of Cancer: How Mechanobiology Drives Cancer Progression submission deadline 15 Aug 2026 | 1 articles | Viewed by 2731 | Submission Open
Keywords: migration and invasion of cancer cells; cytomechanics and adhesive properties; cellular mechanotransduction; mechanical signals; viscoelasticity and stiffness; physics of cancer
Autophagy-Related Proteins in Stress Responses submission deadline 20 Aug 2026 | Viewed by 26 | Submission Open
Keywords: stress response; ATG; endocytosis; exocytosis; autophagy
(This special issue belongs to the Section Autophagy)
Cellular and Molecular Mechanisms of Abiotic Stress Tolerance in Plants
edited by Aziz Khan and
submission deadline 25 Aug 2026 | 2 articles | Viewed by 9624 | Submission Open
Keywords: abiotic stress; molecular mechanism; gene expression; cellular adaptation; signal transduction; plant physiology; molecular pathway; stress resilience; crop productivity; agronomic performance
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
From Protection to Pathology: Beneficial and Deleterious Roles of Extracellular Vesicle Cargo
edited by
submission deadline 25 Aug 2026 | Viewed by 1 | Submission Open
Keywords: extracellular vesicle cargo profiling; exosome cargo heterogeneity; EV cargo modulation; small EV bioengineering; therapeutic cargo loading; engineered exosomes; targeted EV delivery
(This special issue belongs to the Section Intracellular and Plasma Membranes)
Aging and Neurodegeneration: Molecular Insights and Emerging Strategies submission deadline 30 Aug 2026 | 2 articles | Viewed by 3877 | Submission Open
Keywords: Alzheimer’ s disease; biomarkers; endolysosomal pathway; extracellular vesicles; inflammation; mitophagy; neurodegeneration; neuroinflammation; Parkinson’ s disease; translational research
(This special issue belongs to the Section Cellular Aging)
Redox Regulation by Nrf2 in Health and Disease
edited by Pandu Gangula
submission deadline 30 Aug 2026 | 1 articles | Viewed by 1114 | Submission Open
Keywords: Nrf2; redox; cellular stress response; antioxidant gene regulation; signaling pathway crosstalk; oxidative stress response
Epigenetic Plasticity: How Chromatin Dynamics Orchestrate Fundamental Life Processes
edited by and Subhash Chandra Sethi
submission deadline 30 Aug 2026 | Viewed by 43 | Submission Open
Keywords: chromatin organization; chromatin remodelers; epigenetic modifications; epigenetic modifiers; chromosome segregation; transcription; DNA replication; DNA damage and repair; cancer; aging
(This special issue belongs to the Section Cell and Gene Therapy)
The Spatial and Temporal Dynamics of the Tumor Microenvironment
edited by , Abhishek Gupta, Anjali Trivedi and
submission deadline 31 Aug 2026 | Viewed by 602 | Submission Open
Keywords: tumor microenvironment; spatial heterogeneity; spatial transcriptomics; tumor evolution; immune landscape; extracellular matrix; tumor– immune crosstalk; cancer heterogeneity; intra-tumoral heterogeneity; tumor niches
(This special issue belongs to the Section Cell Microenvironment)
New Molecular Insights into Hepatitis and Hepatic Cancer
edited by
submission deadline 31 Aug 2026 | Viewed by 214 | Submission Open
Keywords: hepatitis; alcoholic and non-alcoholic steatohepatitis; HBV and HCV; hepatic Cancer; hepatocellular carcinoma; chronic liver disease; cellular and molecular basis; signaling pathways; antiviral therapies; immunotherapy; therapeutic advances
(This special issue belongs to the Section Cellular Pathology)
Gut Microbiota, Metabolites, and Immune Regulation in Gastrointestinal Diseases
edited by and Subir Kumar Juin
submission deadline 31 Aug 2026 | Viewed by 203 | Submission Open
Keywords: gut microbiota; microbial metabolites; inflammation; immunology; gut-barrier; gastrointestinal disease
Turning Points in α-Synuclein Biology: From Function to Dysfunction
edited by and
submission deadline 31 Aug 2026 | Viewed by 51 | Submission Open
Keywords: α -synuclein; protein aggregation; pathological conversion; synucleinopathies; Parkinson’ s disease; neurodegeneration; neurotoxicity; proteostasis; mitochondrial dysfunction; autophagy
(This special issue belongs to the Section Cellular Neuroscience)
Novel Insights into G-Protein-Coupled Receptor Biology: From Structure to Signaling Regulation
edited by and Bruno Catalanotti
submission deadline 31 Aug 2026 | Viewed by 35 | Submission Open
Keywords: GPCR signaling; structure– function; allosteric modulation; receptor; homology modeling; computational chemistry; AI-based prediction; signal transduction; cellular regulation
Sickle Cell Disease: Current Advances on Molecular Mechanisms and Therapeutic Strategies
edited by and Paula Faustino
submission deadline 31 Aug 2026 | Viewed by 28 | Submission Open
Keywords: sickle cell disease; genetic modifiers; gene editing; SCD pathophysiology; SCD biomarkers; SCD treatment; SCD management
(This special issue belongs to the Section Cellular Pathology)
Recent Discoveries and Progress in Central Nervous System Neuroinflammation
edited by
submission deadline 31 Aug 2026 | Viewed by 20 | Submission Open
Keywords: autoimmune; cerebrovascular; diagnosis; immune cells; microglia; neoplastic; neurodegenerative; neuroinflammation; system interaction; therapeutic targets
(This special issue belongs to the Section Cellular Neuroscience)
Building the Neurons: Cytoskeleton Dynamics and Organelle Interaction in Health and Disease
edited by Xing Liang and
submission deadline 1 Sep 2026 | Viewed by 25 | Submission Open
Keywords: development and health of neurons; cytoskeleton dynamic; organelle interactions
(This special issue belongs to the Section Cellular Neuroscience)
Lipid Homeostasis in Health and Disease
edited by
submission deadline 20 Sep 2026 | Viewed by 137 | Submission Open
Keywords: lipids; metabolism; homeostasis; disease mechanisms; biomarkers; therapeutic targets; nutrition; cellular signaling; systems biology
Role of Transposons in Regulating the Neural Genome and the Mechanisms of Neuropsychiatric Diseases
edited by Fabio M. Macciardi
submission deadline 20 Sep 2026 | Viewed by 94 | Submission Open
Keywords: transposable elements; genome evolution; central nervous system development; neural genome; neural gene regulation; neuropsychiatric disorders
(This special issue belongs to the Section Cellular Neuroscience)
Stem Cells and Metabolism in Acute Myeloid Leukemia: Mechanisms, Models, and Therapeutic Opportunities
edited by , Aditi Chatterjee and Maria Baer
submission deadline 25 Sep 2026 | Viewed by 481 | Submission Open
Keywords: AML; leukemic stem cells; hypoxia; metabolism; fatty-acid oxidation; one-carbon metabolism; proteostasis; bone-marrow niche; multi-omics; metabolic inhibitors
Dysregulated Synaptic Plasticity in Chronic Pain: Molecular Mechanisms, Circuit Dysfunction, and Translational Approaches
edited by
submission deadline 25 Sep 2026 | Viewed by 179 | Submission Open
Keywords: chronic pain; synaptic plasticity; circuit dysfunction
(This special issue belongs to the Section Cellular Pathology)
Antioxidants in Redox Homeostasis of Plant Development submission deadline 30 Sep 2026 | 3 articles | Viewed by 7491 | Submission Open
Keywords: reactive oxygen species; radical scavenging; oxidative stress; plant growth and development; primary and secondary metabolites
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
The Blueprint of Female Reproductive Longevity: From Ovarian Biology to Modifiable Risks and Protective Strategies submission deadline 30 Sep 2026 | 1 articles | Viewed by 1990 | Submission Open
Keywords: ovarian aging; folliculogenesis; oocyte quality; hormonal regulation; epigenetics of reproduction; reproductive lifespan; stem cells in ovarian function; oxidative stress and fertility; metabolic influences on reproduction; cellular signaling in ovarian decline
(This special issue belongs to the Section Reproductive Cells and Development)
The Cellular and Molecular Basis of Lifestyle Factors in Cancer Progression and Prevention
edited by Vivek Kumar Kashyap and Himanshu Narayan Singh
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1908 | Submission Open
Keywords: lifestyle factors; smoking; alcohol consumption; cancer risk; cancer prevention recommendations; modifiable risk factors
(This special issue belongs to the Section Cellular Pathology)
Brain Organoids for Disease Modeling
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1310 | Submission Open
Keywords: brain organoids; induced pluripotent stem cells (iPSCs); neurodevelopmental disorders; neurodegenerative diseases; neuronal activity; organoid-based drug screening
(This special issue belongs to the Section Stem Cells)
Stress Signaling and Cell Fate Determination: The Role of Mitochondria submission deadline 30 Sep 2026 | 1 articles | Viewed by 555 | Submission Open
Keywords: mitochondria; cell death; integrated stress response; retrograde signaling; apoptosis; necroptosis; ferroptosis; mitophagy; mitochondrial dynamics; ROS; calcium signaling; inter-organelle communication
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