Due to scheduled maintenance work on our servers, there may be short service disruptions on this website between 11:00 and 12:00 CEST on March 28th.

Building the Neurons: Cytoskeleton Dynamics and Organelle Interaction in Health and Disease

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Neuroscience".

Deadline for manuscript submissions: 1 September 2026 | Viewed by 694

Special Issue Editors


E-Mail Website
Guest Editor
Department of Biology, Stanford University, Stanford, CA 94305, USA
Interests: neuronal development; neuronal polarity; microtubule polarity; microtubule dynamic

E-Mail Website
Guest Editor
Institute of Anatomy, Rostock University Medical Center, 18057 Rostock, Germany
Interests: neuroinflammation; neurodegeneration; bacterial meningitis; antimicrobial peptides; Alzheimer disease; multiple sclerosis; glia cells; pattern recognition receptors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The cytoskeleton’s dynamics and its interactions with organelles are fundamental to neuronal development and the maintenance of neuronal health. Disruptions in these processes are implicated in a wide range of neurodevelopmental and neurodegenerative disorders. Recent research has highlighted the crucial role of cytoskeleton—organelle interactions in regulating intracellular transport, organelle distribution, and cellular homeostasis processes essential for synapse formation and neuronal plasticity.

To understand how these interactions are established and maintained during development, and how their dysregulation contributes to disease, is critical for elucidating the mechanisms underlying neuronal health.

Advances in live-cell imaging, super-resolution microscopy, proteomics and endogenous protein labeling are now providing unprecedented insights into the mechanism studies of these dynamic interactions.

For this specific issue, we welcome the submission of original research articles and reviews that investigate cytoskeleton-organelle interactions in neurons. We are particularly interested in studies that employ novel methodological approaches to explore new interaction mechanisms in both physiological and pathological contexts.

Dr. Xing Liang
Prof. Dr. Lars Ove Brandenburg
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • development and health of neurons
  • cytoskeleton dynamic
  • organelle interactions

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

49 pages, 2111 KB  
Review
Architects of the Developing Brain: Cytoskeleton-Organizing Molecules in Neurodevelopmental Disorders
by Ksenia A. Achkasova, Pavel V. Subbotin, Vadim V. Zhukov, Anastasia E. Filat’eva, Victor S. Tarabykin and Elena V. Kondakova
Cells 2026, 15(6), 537; https://doi.org/10.3390/cells15060537 - 17 Mar 2026
Viewed by 446
Abstract
Different components of the cytoskeleton are very important determinants of brain development. They orchestrate multiple cellular processes involved in all phases of cerebral cortex development. In this review, we summarize current knowledge on the components of the cytoskeleton—microtubules, actin filaments, and intermediate filaments—and [...] Read more.
Different components of the cytoskeleton are very important determinants of brain development. They orchestrate multiple cellular processes involved in all phases of cerebral cortex development. In this review, we summarize current knowledge on the components of the cytoskeleton—microtubules, actin filaments, and intermediate filaments—and their roles in cortical development. We provide a detailed analysis of how cytoskeleton molecules control neuronal progenitor proliferation, neuronal migration, polarization, axon and dendrite specification and outgrowth, and synaptogenesis. We further examine how pathogenic variants in genes encoding cytoskeletal proteins or their regulators disrupt particular steps of neurogenesis and contribute to major neurodevelopmental disorders (NDDs). Focusing on NDDs such as microcephaly, lissencephaly, corpus callosum agenesis, and synaptopathies, we discuss consequences of cytoskeletal dysfunctions causing altered cellular behavior and clinical phenotypes. By linking molecular defects to developmental and phenotypic consequences, this review highlights the cytoskeleton as a central element in neurodevelopmental pathologies and underscores its potential as a target for future therapeutic strategies. Full article
Show Figures

Graphical abstract

Back to TopTop