MET: Signaling, Regulation, and Biological Roles
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: 15 July 2026 | Viewed by 14
Special Issue Editors
Interests: cancer; cell signaling; protein kinase; RTK; migration; invasion; drug discovery
2. Department of Pathology and Laboratory Science, University of British Columbia, Vancouver, BC, Canada
Interests: lung cancer; cancer genomics; mouse models; oncogene signaling; immune response; targeted therapies
Special Issue Information
Dear Colleagues,
The MET receptor tyrosine kinase (RTK), activated by its ligand hepatocyte growth factor (HGF), governs a broad spectrum of physiological processes, including cell motility, invasion, and tissue remodeling. The initial discovery and characterization of MET emerged from the seminal work of George F. Vande Woude and colleagues, who first identified MET in its constitutively active form, Tpr-Met, resulting from chromosomal rearrangements induced by the carcinogen N-methyl-N′-nitro-N-nitrosoguanidine in a human osteogenic sarcoma cell line.
Over the past four decades, this discovery has paved the way for extensive research aimed at examining the structural and functional properties of MET. These efforts have expanded our understanding of receptor regulation, defined the complexity of the Met signalosome, delineated mechanisms of activation and dysregulation, and steered the development of pharmacological and molecular strategies to reverse these abnormalities.
This Special Issue brings together original research articles, comprehensive reviews, and perspectives that advance our current understanding of MET signaling, regulation, and biological functions. Contributions from both basic and clinical researchers are welcome, particularly those exploring the role of MET in cancer initiation and progression, mechanisms of receptor activation, and emerging therapeutic strategies targeting MET aberrant activation.
Dr. Abdulhameed Al-Ghabkari
Dr. William W. Lockwood
Guest Editors
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Keywords
- MET
- HGF (hepatocyte growth factor)
- MET signaling
- receptor tyrosine kinase (RTK)
- cancer
- tumor progression
- receptor activation
- MET-targeted therapy
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