Extracellular Vesicles: Drivers, Biomarkers, and Therapeutics in Cardiovascular Disease
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 July 2026 | Viewed by 38
Special Issue Editor
Interests: RNA biology; exosomes; multiomics; cardiovascular; biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiovascular disease (CVD) remains the world’s leading cause of death, urgently requiring new approaches for prevention, treatment, and cure. Existing therapies are often suboptimal, leading to poor outcomes, side effects, and drug interactions. Extracellular vesicles (EVs) are emerging as powerful tools with dual promise in both therapeutics and biomarker discovery.
EVs can deliver beneficial molecules, including RNAs and proteins, and can be engineered as delivery vehicles for therapeutic payloads. At the same time, circulating EVs or tissue-specific EVs capture molecular signals reflecting pathological and physiological states, making them excellent candidates for liquid biopsy biomarkers, patient stratification, and pharmacodynamic monitoring in cardiovascular treatments. In conditions such as fibrosis and atherosclerosis, EVs propagate pathological molecules and signaling, suggesting that targeting disease-driving EVs could be a novel therapeutic strategy.
This Special Issue will highlight how EVs act as drivers, biomarkers, and therapeutic agents in cardiovascular disease. Contributions that span fundamental biology and translational applications, with emphasis on the following:
- Mechanisms by which EVs drive cardiovascular pathology;
- Development of EVs as therapeutic delivery systems;
- EVs as biomarkers for diagnosis, patient stratification, and treatment monitoring;
- Novel technologies to engineer, amplify, or target EVs for CVD therapy;
- Multiomics of EVs to understand biomarker discovery and therapeutics focused on RNA, DNA, and protein;
- Cardiovascular and systemic tissue crosstalk.
Dr. Prabhu Mathiyalagan
Guest Editor
Manuscript Submission Information
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Keywords
- cardiovascular disease
- extracellular vesicles
- biomarkers
- therapeutics
- drug delivery
- RNA therapeutics
- fibrosis
- atherosclerosis
- liquid biopsy
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